iPTMnet Report for P33527 (ABCC1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P33527 / MRP1_HUMAN
Protein Name Multidrug resistance-associated protein 1
Gene Name Name: ABCC1
Synonyms:MRP,MRP1;
Organism Homo sapiens (Human)

PRO ID PR:P33527
DAG View
PRO Name multidrug resistance-associated protein 1 (human)
Definition A multidrug resistance-associated protein 1 that is encoded in the genome of human.
Short Label hABCC1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P33527 (ABCC1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N19 N-Glycosylation GlyGen   UniProt 9295302
N23 N-Glycosylation GlyGen   UniProt 9295302
K72 Ubiquitination PhosphoSitePlus
K246 Ubiquitination PhosphoSitePlus
T249 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   RLIMS-P   Signor 22695718
K259 Ubiquitination PhosphoSitePlus
K274 Ubiquitination PhosphoSitePlus
Y277 Phosphorylation PhosphoSitePlus
S279 Phosphorylation PhosphoSitePlus
K280 Ubiquitination PhosphoSitePlus
S289 Phosphorylation PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
K315 Ubiquitination PhosphoSitePlus
C388 Methylation IEDB 31844290
K396 Ubiquitination PhosphoSitePlus
Y404 Phosphorylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K416 Ubiquitination PhosphoSitePlus
K488 Ubiquitination PhosphoSitePlus
K496 Ubiquitination PhosphoSitePlus
S497 Phosphorylation PhosphoSitePlus
K498 Acetylation PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
K503 Acetylation PhosphoSitePlus
K503 Ubiquitination PhosphoSitePlus
K513 Ubiquitination PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
K527 Ubiquitination PhosphoSitePlus
K636 Ubiquitination PhosphoSitePlus
K764 Ubiquitination PhosphoSitePlus
K773 Ubiquitination PhosphoSitePlus
K804 Ubiquitination PhosphoSitePlus
K814 Ubiquitination PhosphoSitePlus
K818 Ubiquitination PhosphoSitePlus
S847 Phosphorylation PhosphoSitePlus
Y852 Phosphorylation PhosphoSitePlus
S871 Phosphorylation PhosphoSitePlus
T872 Phosphorylation PhosphoSitePlus
K891 Ubiquitination PhosphoSitePlus
K894 Ubiquitination PhosphoSitePlus
S905 Phosphorylation PhosphoSitePlus   UniProt 20068231
K908 Ubiquitination PhosphoSitePlus
S915 Phosphorylation PhosphoSitePlus   UniProt 23186163, 19690332
S916 Phosphorylation PhosphoSitePlus
S917 Phosphorylation PhosphoSitePlus
S918 Phosphorylation PhosphoSitePlus
S919 Phosphorylation PhosphoSitePlus
Y920 Phosphorylation PhosphoSitePlus
S921 Phosphorylation PhosphoSitePlus
S925 Phosphorylation PhosphoSitePlus
S930 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 21406692, 17081983, 20068231
T931 Phosphorylation PhosphoSitePlus
K936 Ubiquitination PhosphoSitePlus
K946 Ubiquitination PhosphoSitePlus
K952 Ubiquitination PhosphoSitePlus
S961 Phosphorylation PhosphoSitePlus
N1006 N-Glycosylation GlyGen   UniProt 9295302
K1078 Ubiquitination PhosphoSitePlus
S1145 Phosphorylation PhosphoSitePlus
K1181 Ubiquitination PhosphoSitePlus
K1187 Ubiquitination PhosphoSitePlus
Y1189 Phosphorylation IEDB 32387766
Y1243 Phosphorylation PhosphoSitePlus
K1265 Ubiquitination PhosphoSitePlus
K1272 Ubiquitination PhosphoSitePlus
K1322 Ubiquitination PhosphoSitePlus
K1333 Ubiquitination PhosphoSitePlus
K1360 Ubiquitination PhosphoSitePlus
K1369 Ubiquitination PhosphoSitePlus
K1502 Ubiquitination PhosphoSitePlus
Y1508 Phosphorylation PhosphoSitePlus
Y1522 Phosphorylation PhosphoSitePlus
S1523 Phosphorylation PhosphoSitePlus
K1526 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S847 Phosphorylation HPRD 19413330
S905 Phosphorylation HPRD 20068231
S915 Phosphorylation HPRD 19651622, 18691976
S917 Phosphorylation HPRD 19413330, 18767875
S918 Phosphorylation HPRD 19651622, 18767875
S919 Phosphorylation HPRD 18767875, 19664994
Y920 Phosphorylation HPRD 19651622
S930 Phosphorylation HPRD 19651622, 18578522, 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y277 H277 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ icgc ]
S279 F279 Biomuta DOID:1793 / pancreatic cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S289 Y289 Biomuta DOID:1324 / lung cancer [ cosmic ]
S289 F289 Biomuta DOID:4159 / skin cancer [ cosmic ]
K290 T290 Biomuta DOID:4159 / skin cancer [ cosmic ]
K290 N290 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
K496 N496 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ] DOID:4606 / bile duct cancer [ cosmic ]
S497 N497 Biomuta DOID:4159 / skin cancer [ cosmic ]
K513 E513 Biomuta DOID:263 / kidney cancer [ cosmic ]
K513 Q513 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S847 C847 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K891 M891 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S916 C916 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S917 F917 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S919 Y919 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S921 N921 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S961 F961 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
Y1189 C1189 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
K1322 N1322 Biomuta DOID:1319 / brain cancer [ icgc ]
K1333 R1333 Biomuta DOID:3571 / liver cancer [ cosmic ]
Y1508 H1508 Biomuta DOID:9256 / colorectal cancer [ cosmic, icgc ]
S1523 I1523 Biomuta DOID:1612 / breast cancer [ cosmic ]