iPTMnet Report for P33402 (GUCY1A2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P33402 / GCYA2_HUMAN
Protein Name Guanylate cyclase soluble subunit alpha-2
Gene Name Name: GUCY1A2
Synonyms:GUC1A2,GUCSA2;
Organism Homo sapiens (Human)

PRO ID PR:P33402
DAG View
PRO Name guanylate cyclase soluble subunit alpha-2 (human)
Definition A guanylate cyclase soluble subunit alpha-2 that is encoded in the genome of human.
Short Label hGUCY1A2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P33402 (GUCY1A2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S41 Phosphorylation PhosphoSitePlus
S89 Phosphorylation PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
T108 Phosphorylation PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
K466 Acetylation PhosphoSitePlus
S619 Phosphorylation PhosphoSitePlus
S621 Phosphorylation PhosphoSitePlus
S671 Phosphorylation PhosphoSitePlus
T673 Phosphorylation PhosphoSitePlus
T701 Phosphorylation PhosphoSitePlus
S719 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K466 E466 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S671 N671 Biomuta DOID:1324 / lung cancer [ cosmic ]
S671 R671 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S719 F719 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]