iPTMnet Report for P33316 (DUT)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P33316 / DUT_HUMAN
Protein Name Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial precursor
Gene Name Name: DUT
Organism Homo sapiens (Human)

PRO ID PR:P33316
DAG View
PRO Name deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial (human)
Definition A deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial that is encoded in the genome of human.
Short Label hDUT
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P33316 (DUT) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C5 Methylation IEDB 31844290
C11 Phosphorylation UniProt 8631817, 21406692, 20068231
S21 Phosphorylation PhosphoSitePlus
R47 Methylation PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
S59 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
R68 Methylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus   UniProt 23186163, 20068231, 24275569
T95 Phosphorylation PhosphoSitePlus
S99 Phosphorylation IEDB   phospho.ELM   PhosphoSitePlus   UniProt 35494241, 23186163, 18234856, ...8389461, 31848261, 27869121
S99 Phosphorylation P06493 (CDK1) PhosphoSitePlus 18234856
R115 Methylation PhosphoSitePlus
T124 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T127 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
R128 Methylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
K155 Acetylation PhosphoSitePlus
K155 Ubiquitination PhosphoSitePlus
S164 Phosphorylation PhosphoSitePlus
C166 Methylation IEDB 31844290
C166 S-Nitrosylation dbSNO 26338901
Y167 Phosphorylation PhosphoSitePlus
K179 Acetylation PhosphoSitePlus
K179 Ubiquitination PhosphoSitePlus
Y193 Phosphorylation PhosphoSitePlus
K206 Ubiquitination PhosphoSitePlus
K208 Ubiquitination PhosphoSitePlus
R216 Methylation PhosphoSitePlus
C222 Methylation IEDB 31844290
R224 Methylation PhosphoSitePlus
T239 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
R241 Methylation PhosphoSitePlus
S243 Phosphorylation PhosphoSitePlus
S248 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T249 Phosphorylation PhosphoSitePlus
K251 Acetylation PhosphoSitePlus
K251 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S4 Phosphorylation PhosphoSitePlus
T7 Phosphorylation HPRD   PhosphoSitePlus 19664995
S11 Phosphorylation HPRD   neXtProt   PhosphoSitePlus 18212344, 19664995, 19651622, ...8631817, 19415658, 20068231
S11 Phosphorylation P06493 (CDK1) HPRD   PhosphoSitePlus 18212344, 19664995, 19651622, ...8631817, 19415658, 20068231
S13 Phosphorylation HPRD   PhosphoSitePlus 19651622, 19664995, 20068231
K14 Acetylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
T151 Phosphorylation HPRD 18669648, 20068231
S155 Phosphorylation HPRD 20068231
S160 Phosphorylation HPRD 18669648, 20068231
T161 Phosphorylation HPRD 20068231
K163 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S88 Phosphorylation HPRD 20068231
S99 Phosphorylation HPRD 20068231
T239 Phosphorylation HPRD 18669648, 20068231
S243 Phosphorylation HPRD 20068231
S248 Phosphorylation HPRD 18669648, 20068231
T249 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T7 S7 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
R68 S68 Biomuta DOID:10534 / stomach cancer [ icgc ]
T95 S95 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
K151 R151 Biomuta DOID:363 / uterine cancer [ icgc ]
K163 N163 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]
K208 E208 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R216 L216 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R216 * Biomuta DOID:363 / uterine cancer [ cosmic ]
R216 Q216 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
R224 L224 Biomuta DOID:363 / uterine cancer [ icgc ]
K251 N251 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, icgc ]