iPTMnet Report for P33176 (KIF5B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P33176 / KINH_HUMAN
Protein Name Kinesin-1 heavy chain
Gene Name Name: KIF5B
Synonyms:KNS,KNS1;
Organism Homo sapiens (Human)

PRO ID PR:P33176
DAG View
PRO Name kinesin-1 heavy chain (human)
Definition A kinesin-1 heavy chain that is encoded in the genome of human.
Short Label hKIF5B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P33176 (KIF5B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895
K10 Acetylation PhosphoSitePlus
K10 Ubiquitination PhosphoSitePlus
S21 Phosphorylation PhosphoSitePlus
K28 Acetylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus
K44 Ubiquitination PhosphoSitePlus
S55 Phosphorylation PhosphoSitePlus
C65 S-Nitrosylation dbSNO 2212679, 22126794
K67 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
S154 Phosphorylation PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
K166 Acetylation PhosphoSitePlus
S175 Phosphorylation PhosphoSitePlus
S206 Phosphorylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K252 Ubiquitination PhosphoSitePlus
Y277 Phosphorylation PhosphoSitePlus
N308 N-Glycosylation GlyGen 32125861
R321 Methylation PhosphoSitePlus
K346 Acetylation PhosphoSitePlus
K382 Ubiquitination PhosphoSitePlus
K384 Ubiquitination PhosphoSitePlus
K394 Ubiquitination PhosphoSitePlus
T397 Phosphorylation PhosphoSitePlus
T399 Phosphorylation PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
T405 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 34725712, 29351928, 34019948, 31373491
T405 Phosphorylation PhosphoSitePlus
T414 Phosphorylation PhosphoSitePlus
K420 Ubiquitination PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K430 Ubiquitination PhosphoSitePlus
K448 Ubiquitination PhosphoSitePlus
T451 Phosphorylation PhosphoSitePlus
T463 Phosphorylation PhosphoSitePlus
R464 Methylation PhosphoSitePlus
K505 Ubiquitination PhosphoSitePlus
K514 Ubiquitination PhosphoSitePlus
Y516 Phosphorylation PhosphoSitePlus
K526 Ubiquitination PhosphoSitePlus
K539 Ubiquitination PhosphoSitePlus
K549 Acetylation PhosphoSitePlus
K560 Acetylation PhosphoSitePlus
Y593 Phosphorylation PhosphoSitePlus
S599 Phosphorylation PhosphoSitePlus
K602 Acetylation PhosphoSitePlus
K609 Acetylation PhosphoSitePlus
K609 Ubiquitination PhosphoSitePlus
C632 S-Nitrosylation dbSNO 26338901
K644 Ubiquitination PhosphoSitePlus
S645 Phosphorylation PhosphoSitePlus
Y649 Phosphorylation PhosphoSitePlus
K656 Ubiquitination PhosphoSitePlus
K657 Ubiquitination PhosphoSitePlus
S663 Phosphorylation PhosphoSitePlus
K679 Ubiquitination PhosphoSitePlus
K690 Ubiquitination PhosphoSitePlus
K698 Ubiquitination PhosphoSitePlus
K761 Acetylation PhosphoSitePlus
K764 Acetylation PhosphoSitePlus
K764 Ubiquitination PhosphoSitePlus
K783 Ubiquitination PhosphoSitePlus
K791 Ubiquitination PhosphoSitePlus
K801 Acetylation PhosphoSitePlus
K801 Ubiquitination PhosphoSitePlus
S814 Phosphorylation PhosphoSitePlus
S819 Phosphorylation PhosphoSitePlus
S825 Phosphorylation PhosphoSitePlus
S833 Phosphorylation PhosphoSitePlus
K844 Ubiquitination PhosphoSitePlus
K847 Ubiquitination PhosphoSitePlus
R901 Methylation PhosphoSitePlus
S917 Phosphorylation HPRD 20068231
K922 Ubiquitination PhosphoSitePlus
S933 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19651622, 17081983, 20068231
T935 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983
S938 Phosphorylation HPRD   PhosphoSitePlus 20068231
S950 O-Glycosylation GlyGen 23301498, 35008409, 33214551, ...35138101, 34725712, 29351928, 34019948, 31373491
S950 Phosphorylation PhosphoSitePlus
R956 Methylation PhosphoSitePlus   UniProt 24129315


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation Q9UQF2 (MAPK8IP1) S421 P33176 (KIF5B) unknown eFIP 23897889


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 V2 Biomuta DOID:184 / bone cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ]
S43 T43 Biomuta DOID:363 / uterine cancer [ cosmic ]
S55 R55 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
K222 R222 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
R321 G321 Biomuta DOID:4159 / skin cancer [ cosmic ]
T451 M451 Biomuta DOID:10534 / stomach cancer [ cosmic ]
K505 T505 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K505 R505 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
Y516 N516 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
K539 T539 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K549 N549 Biomuta DOID:1324 / lung cancer [ cosmic ]
K602 Q602 Biomuta DOID:4159 / skin cancer [ cosmic ]
C632 R632 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K656 R656 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S663 F663 Biomuta DOID:4159 / skin cancer [ cosmic ]
K844 N844 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
R901 H901 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R901 C901 Biomuta DOID:1319 / brain cancer [ icgc ]
R956 * Biomuta [ cosmic ]