iPTMnet Report for P33151 (CDH5)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P33151 / CADH5_HUMAN
Protein Name Cadherin-5 precursor
Gene Name Name: CDH5
Organism Homo sapiens (Human)

PRO ID PR:P33151
DAG View
PRO Name cadherin-5 (human)
Definition A cadherin-5 that is encoded in the genome of human.
Short Label hCDH5
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P33151 (CDH5) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
N61 N-Glycosylation GlyGen   UniProt 23090970, 19139490, 21269602, ...29391424
T62 Phosphorylation PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
Y82 Phosphorylation PhosphoSitePlus
N112 N-Glycosylation GlyGen   UniProt 16335952, 19139490, 21269602, ...29391424, 23345538
N157 N-Glycosylation GlyGen   UniProt 21269602
T212 Phosphorylation PhosphoSitePlus
Y223 Phosphorylation PhosphoSitePlus
N362 N-Glycosylation GlyGen   UniProt 21269602
T392 Phosphorylation PhosphoSitePlus
N442 N-Glycosylation GlyGen   UniProt 16335952, 24190977, 23090970, ...29391424, 19139490, 23345538, 21269602
N523 N-Glycosylation GlyGen   UniProt 16335952
N535 N-Glycosylation GlyGen   UniProt 16335952, 29741879, 29391424
Y658 Phosphorylation PhosphoSitePlus   RLIMS-P 19212436, 27852896, 22629427, ...21464949, 27344258, 28393886, 20048167, 24136461, 25447529, 16027153, 26681130, 23169049, 28712573, 20308428, 25156554, 17785844, 24590762, 30419037, 25770237, 31973024
Y658 Phosphorylation P12931 (SRC) PhosphoSitePlus 16027153
S665 Phosphorylation PhosphoSitePlus   RLIMS-P 21464949, 22629427
S683 Phosphorylation PhosphoSitePlus
Y685 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 26598555, 21464949, 20048167, ...18083107, 21858121, 23169049, 27381080, 21123455, 25030698, 31927409, 20308428, 16909109, 24358106
Y685 Phosphorylation P12931 (SRC) PhosphoSitePlus   Signor 16909109
Y725 Phosphorylation PhosphoSitePlus
Y731 Phosphorylation PhosphoSitePlus   RLIMS-P 19212436, 16027153, 21464949, ...24965120, 28393886, 20048167, 24136461, 25447529, 22303475, 22285407, 27381080, 20308428, 21660952, 30814488, 17785844, 30419037
Y731 Phosphorylation P12931 (SRC) PhosphoSitePlus 16027153
Y733 Phosphorylation PhosphoSitePlus
Y774 Phosphorylation PhosphoSitePlus
S776 Phosphorylation RLIMS-P 20047332
Y784 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N112 N-Glycosylation PRO 23345538
N442 N-Glycosylation PRO 23345538
Y658 Phosphorylation HPRD 16027153
Y658 Phosphorylation P12931 (SRC) HPRD 16027153
Y685 Phosphorylation HPRD 18083107
Y731 Phosphorylation HPRD 16027153
Y731 Phosphorylation P12931 (SRC) HPRD 16027153


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P33151 (CDH5) Y658 O60716 (CTNND1) increased_association eFIP 24590762
Phosphorylation P33151 (CDH5) S776 Q8TEW0 (PARD3) increased_association eFIP 20047332
Phosphorylation P33151 (CDH5) Y658 O60716 (CTNND1) decreased_association eFIP 27852896
Phosphorylation Q14289 (PTK2B) Y402 P33151 (CDH5) unknown eFIP 20308428


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T212 M212 Biomuta DOID:1324 / lung cancer [ cosmic ]
N523 K523 Biomuta DOID:9256 / colorectal cancer [ icgc ] DOID:10283 / prostate cancer [ cosmic ]
S665 L665 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ]
Y774 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S776 L776 Biomuta DOID:4159 / skin cancer [ cosmic ]