iPTMnet Report for P33121 (ACSL1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P33121 / ACSL1_HUMAN
Protein Name Long-chain-fatty-acid--CoA ligase 1
Gene Name Name: ACSL1
Synonyms:FACL1,FACL2,LACS,LACS1,LACS2;
Organism Homo sapiens (Human)

PRO ID PR:P33121
DAG View
PRO Name long-chain-fatty-acid--CoA ligase 1 (human)
Definition A long-chain-fatty-acid--CoA ligase 1 that is encoded in the genome of human.
Short Label hACSL1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P33121 (ACSL1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S103 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
C132 Methylation IEDB 31844290
Y188 Phosphorylation PhosphoSitePlus
K216 Ubiquitination PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
S232 Phosphorylation PhosphoSitePlus
C241 Methylation IEDB 31844290
K356 Ubiquitination PhosphoSitePlus
K386 Acetylation PhosphoSitePlus
S394 Phosphorylation PhosphoSitePlus
K395 Acetylation PhosphoSitePlus
K395 Ubiquitination PhosphoSitePlus
S410 Phosphorylation PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
S439 Phosphorylation PhosphoSitePlus
C486 Methylation IEDB 31844290
K532 Ubiquitination PhosphoSitePlus
K561 Acetylation PhosphoSitePlus
Y567 Phosphorylation PhosphoSitePlus
Y577 Phosphorylation PhosphoSitePlus
S620 Phosphorylation PhosphoSitePlus   UniProt 24275569
K643 Ubiquitination PhosphoSitePlus
S664 Phosphorylation PhosphoSitePlus
T671 Phosphorylation PhosphoSitePlus
Y693 Phosphorylation PhosphoSitePlus
T695 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S58 Phosphorylation HPRD 20068231
S103 Phosphorylation HPRD 20068231
S394 Phosphorylation HPRD 20058876


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S410 I410 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
C486 * Biomuta DOID:4159 / skin cancer [ cosmic ]
K561 N561 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S664 F664 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S664 A664 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y693 F693 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]