iPTMnet Report for P32929 (CTH)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P32929 / CGL_HUMAN
Protein Name Cystathionine gamma-lyase
Gene Name Name: CTH
Organism Homo sapiens (Human)

PRO ID PR:P32929
DAG View
PRO Name cystathionine gamma-lyase (human)
Definition A cystathionine gamma-lyase that is encoded in the genome of human.
Short Label hCTH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P32929 (CTH) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation phospho.ELM   PhosphoSitePlus 17525332
K48 Ubiquitination PhosphoSitePlus
S56 Phosphorylation PhosphoSitePlus
Y60 Phosphorylation PhosphoSitePlus
K73 Acetylation PhosphoSitePlus
K73 Ubiquitination PhosphoSitePlus
C137 Methylation IEDB 31844290
S138 O-Glycosylation GlyGen 16408927, 33626323, 35138101
K139 Ubiquitination PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
C172 Methylation IEDB 31844290
K212 Acetylation PhosphoSitePlus
K288 Ubiquitination PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
K330 Ubiquitination PhosphoSitePlus
S377 Phosphorylation Q13237 (PRKG2) PhosphoSitePlus 25900831
K395 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation HPRD 17525332
Site PTM Type PTM Enzyme Score Source PMID
S8 Phosphorylation HPRD 17525332


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S8 * Biomuta DOID:4606 / bile duct cancer [ cosmic, cosmic ]
Y60 C60 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K395 R395 Biomuta DOID:4159 / skin cancer [ cosmic ]
K395 Q395 Biomuta DOID:2531 / hematologic cancer [ cosmic ]