Protein Information

Cytoscape View

UniProt AC / UniProt ID P32780 / TF2H1_HUMAN
Protein Name General transcription factor IIH subunit 1
Gene Name Name: GTF2H1
Organism Homo sapiens (Human)

PRO ID PR:P32780
DAG View
PRO Name general transcription factor IIH subunit 1 (human)
Definition A general transcription factor IIH subunit 1 that is encoded in the genome of human.
Short Label hGTF2H1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P32780 (GTF2H1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
Y25 Phosphorylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
T74 Phosphorylation PhosphoSitePlus
K93 Ubiquitination PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
S158 Phosphorylation PhosphoSitePlus
Y207 Phosphorylation PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
S239 Phosphorylation PhosphoSitePlus
K240 Acetylation PhosphoSitePlus
K240 Ubiquitination PhosphoSitePlus
K275 Ubiquitination PhosphoSitePlus
K293 Ubiquitination PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
S339 Phosphorylation PhosphoSitePlus   UniProt 23186163
K353 Ubiquitination PhosphoSitePlus
S357 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y360 Phosphorylation PhosphoSitePlus
K365 Ubiquitination PhosphoSitePlus
S368 Phosphorylation PhosphoSitePlus
K377 Ubiquitination PhosphoSitePlus
T415 Phosphorylation PhosphoSitePlus
K504 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S339 Phosphorylation HPRD 19413330
S368 Phosphorylation HPRD 19664995

P32780 (GTF2H1) as PTM Enzyme

Substrate Site Score Source PMID
Q01094 (E2F1) S403 HPRD 10428966
Q01094 (E2F1) T433 HPRD 10428966

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P04637 (TP53) T55 P32780 (GTF2H1) unknown eFIP 16793543

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S158 F158 Biomuta DOID:1909 / melanoma [ tcga ]
S357 F357 Biomuta DOID:10534 / stomach cancer [ tcga ] DOID:1909 / melanoma [ tcga ]
S368 Y368 Biomuta DOID:1612 / breast cancer [ icgc ]