iPTMnet Report for P32322 (PYCR1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P32322 / P5CR1_HUMAN
Protein Name Pyrroline-5-carboxylate reductase 1, mitochondrial
Gene Name Name: PYCR1
Organism Homo sapiens (Human)

PRO ID PR:P32322
DAG View
PRO Name pyrroline-5-carboxylate reductase 1, mitochondrial (human)
Definition A pyrroline-5-carboxylate reductase 1, mitochondrial that is encoded in the genome of human.
Short Label hPYCR1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P32322 (PYCR1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330
K51 Acetylation PhosphoSitePlus
K51 Ubiquitination PhosphoSitePlus
K107 Acetylation PhosphoSitePlus
Y135 Phosphorylation PhosphoSitePlus
K215 Acetylation PhosphoSitePlus
K215 Ubiquitination PhosphoSitePlus
K228 Acetylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
S233 Phosphorylation PhosphoSitePlus
T238 Phosphorylation PhosphoSitePlus
S261 Phosphorylation PhosphoSitePlus
C262 S-Nitrosylation dbSNO 19483679
S270 Phosphorylation PhosphoSitePlus
S278 Phosphorylation PhosphoSitePlus   UniProt 23186163
K283 Ubiquitination PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K291 Ubiquitination PhosphoSitePlus
S294 O-Glycosylation GlyGen 33465208
S294 Phosphorylation PhosphoSitePlus
T298 Phosphorylation PhosphoSitePlus
S301 O-Glycosylation GlyGen 28510447, 35083852, 33465208, ...34229054
S301 Phosphorylation P24941 (CDK2) PhosphoSitePlus   UniProt 18847512, 23186163
S303 O-Glycosylation GlyGen 33465208
S303 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
T306 O-Glycosylation GlyGen 33465208
Site PTM Type PTM Enzyme Score Source PMID
S233 Phosphorylation HPRD 20068231
S303 Phosphorylation HPRD 20068231
Site PTM Type PTM Enzyme Score Source PMID
S233 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y135 F135 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S233 F233 Biomuta DOID:11054 / urinary bladder cancer [ icgc ]
S270 F270 Biomuta DOID:4159 / skin cancer [ cosmic ]
S301 L301 Biomuta DOID:1324 / lung cancer [ cosmic ]