iPTMnet Report P32121 ARRB2

Protein Information

UniProt AC / UniProt ID	P32121 / ARRB2_HUMAN
Protein Name	Beta-arrestin-2
Gene Name	Name: ARRB2 Synonyms:ARB2,ARR2;
Organism	Homo sapiens (Human)

PRO ID	PR:P32121 DAG View
PRO Name	beta-arrestin-2 (human)
Definition	A beta-arrestin-2 that is encoded in the genome of human.
Short Label	hARRB2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P32121 (ARRB2) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S13 S14 T20 K34 Y48 K50 Y64 K78 K108 K153 S159 K171 K178 K230 K231 K233 Y250 T276 K295 K308 S360 T382 Y404	PTM Type Select all Acetylation Phosphorylation Sumoylation Ubiquitination	PTM Enzyme	Score Select all 1 2 4	Source Select all PRO PhosphoSitePlus Signor UniProt phospho.ELM	PMID
	Ubiquitination		score1	PRO
S13	Phosphorylation		score1	PhosphoSitePlus
S14	Phosphorylation	P27361 (MAPK3) , P28482 (MAPK1)	score2	PhosphoSitePlus	26324936
T20	Phosphorylation		score1	PhosphoSitePlus
K34	Ubiquitination		score1	PhosphoSitePlus
Y48	Phosphorylation		score1	PhosphoSitePlus
K50	Ubiquitination		score1	PhosphoSitePlus
Y64	Phosphorylation		score1	PhosphoSitePlus
K78	Ubiquitination		score1	PhosphoSitePlus
K108	Ubiquitination		score1	PhosphoSitePlus
K153	Acetylation		score1	PhosphoSitePlus
K153	Ubiquitination		score1	PhosphoSitePlus
S159	Phosphorylation		score1	PhosphoSitePlus
K171	Ubiquitination		score1	PhosphoSitePlus
K178	Ubiquitination		score1	PhosphoSitePlus
K230	Acetylation		score1	PhosphoSitePlus
K231	Acetylation		score1	PhosphoSitePlus
K233	Acetylation		score1	PhosphoSitePlus
Y250	Phosphorylation		score1	PhosphoSitePlus
T276	Phosphorylation	P28482 (MAPK1) , P27361 (MAPK3)	score2	PhosphoSitePlus	26324936
K295	Sumoylation		score1	PhosphoSitePlus
K295	Ubiquitination		score1	PhosphoSitePlus
K308	Ubiquitination		score1	PhosphoSitePlus
S360	Phosphorylation		score1	PhosphoSitePlus
T382	Phosphorylation	Q02750 (MAP2K1) , P68400 (CSNK2A1)	score4	phospho.ELM PhosphoSitePlus Signor UniProt	11877451, 28169830
Y404	Phosphorylation		score1	PhosphoSitePlus

Search:

	Site Select all By amino acid All Threonine By position T382	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 1	Source Select all HPRD	PMID
	T382	Phosphorylation	P68400 (CSNK2A1) , P19784 (CSNK2A2)	score1	HPRD	11877451

Proteoforms

Search:

	PRO ID (Short Label) Select all PR:000046399 (hARRB2/UbiqLys+)	Sites Select all ub	PTM Enzyme	Source Select all PRO	PMID
	PR:000046399 (hARRB2/UbiqLys+)	ub		PRO

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine By position S159 T276	Variant Select all I276 R159	Source Select all Biomuta	PMID	Disease [Sample source] Select all DOID:10283 / prostate cancer [ cosmic ] DOID:363 / uterine cancer [ cosmic, icgc ]
S159	R159	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ]
T276	I276	Biomuta		DOID:10283 / prostate cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P32121 (ARRB2)

Protein Information

Interactive Sequence View

P32121 (ARRB2) as Substrate

Proteoforms

PTM sites affected in variants