iPTMnet Report for P32121 (ARRB2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P32121 / ARRB2_HUMAN
Protein Name Beta-arrestin-2
Gene Name Name: ARRB2
Synonyms:ARB2,ARR2;
Organism Homo sapiens (Human)

PRO ID PR:P32121
DAG View
PRO Name beta-arrestin-2 (human)
Definition A beta-arrestin-2 that is encoded in the genome of human.
Short Label hARRB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P32121 (ARRB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Ubiquitination PRO
S13 Phosphorylation PhosphoSitePlus
S14 Phosphorylation P27361 (MAPK3) , P28482 (MAPK1) PhosphoSitePlus 26324936
T20 Phosphorylation PhosphoSitePlus
K34 Ubiquitination PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
K50 Ubiquitination PhosphoSitePlus
Y64 Phosphorylation PhosphoSitePlus
K78 Ubiquitination PhosphoSitePlus
K108 Ubiquitination PhosphoSitePlus
K153 Acetylation PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S159 Phosphorylation PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K178 Ubiquitination PhosphoSitePlus
K230 Acetylation PhosphoSitePlus
K231 Acetylation PhosphoSitePlus
K233 Acetylation PhosphoSitePlus
Y250 Phosphorylation PhosphoSitePlus
T276 Phosphorylation P28482 (MAPK1) , P27361 (MAPK3) PhosphoSitePlus 26324936
K295 Sumoylation PhosphoSitePlus
K295 Ubiquitination PhosphoSitePlus
K308 Ubiquitination PhosphoSitePlus
S360 Phosphorylation PhosphoSitePlus
T382 Phosphorylation Q02750 (MAP2K1) , P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   Signor   UniProt 11877451, 28169830
Y404 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T382 Phosphorylation P68400 (CSNK2A1) , P19784 (CSNK2A2) HPRD 11877451


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046399 (hARRB2/UbiqLys+) ub PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S159 R159 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
T276 I276 Biomuta DOID:10283 / prostate cancer [ cosmic ]