iPTMnet Report for P32004 (L1CAM)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P32004 / L1CAM_HUMAN
Protein Name Neural cell adhesion molecule L1 precursor
Gene Name Name: L1CAM
Synonyms:CAML1,MIC5;
Organism Homo sapiens (Human)

PRO ID PR:P32004
DAG View
PRO Name neural cell adhesion molecule L1 (human)
Definition A neural cell adhesion molecule L1 that is encoded in the genome of human.
Short Label hL1CAM
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P32004 (L1CAM) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
K56 Ubiquitination PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
N100 N-Glycosylation GlyGen 24190977
K140 Ubiquitination PhosphoSitePlus
K144 Ubiquitination PhosphoSitePlus
S153 Phosphorylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
K180 Ubiquitination PhosphoSitePlus
N203 N-Glycosylation GlyGen 24190977
K222 Ubiquitination PhosphoSitePlus
K230 Ubiquitination PhosphoSitePlus
N247 N-Glycosylation GlyGen 24190977
N294 N-Glycosylation GlyGen 29741879
K295 Ubiquitination PhosphoSitePlus
K301 Ubiquitination PhosphoSitePlus
K338 Ubiquitination PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
Y418 Phosphorylation PhosphoSitePlus
Y420 Phosphorylation PhosphoSitePlus
N433 N-Glycosylation GlyGen 24190977
N479 N-Glycosylation GlyGen 23090970, 24190977
T481 O-Glycosylation GlyGen 33214551, 28510447, 35083852, ...28657654, 34019948
N490 N-Glycosylation GlyGen 23090970, 24190977
N505 N-Glycosylation GlyGen 29741879
K515 Ubiquitination PhosphoSitePlus
T518 Phosphorylation PhosphoSitePlus
T521 Phosphorylation PhosphoSitePlus
T527 Phosphorylation PhosphoSitePlus
K530 Acetylation PhosphoSitePlus
K568 Ubiquitination PhosphoSitePlus
N588 N-Glycosylation GlyGen 24190977
S611 Phosphorylation PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
K661 Ubiquitination PhosphoSitePlus
K667 Ubiquitination PhosphoSitePlus
N671 N-Glycosylation GlyGen   UniProt 16335952, 23090970, 24190977, ...19159218, 29741879
K694 Ubiquitination PhosphoSitePlus
K716 Ubiquitination PhosphoSitePlus
N726 N-Glycosylation GlyGen 23090970, 24190977
Y784 Phosphorylation PhosphoSitePlus
N849 N-Glycosylation GlyGen 23090970, 24190977
N931 N-Glycosylation GlyGen 24190977
N979 N-Glycosylation GlyGen 23090970, 29671580, 24190977
K998 Ubiquitination PhosphoSitePlus
K1150 Ubiquitination PhosphoSitePlus
Y1151 Phosphorylation PhosphoSitePlus
S1152 Phosphorylation phospho.ELM   PRO   PhosphoSitePlus 8663493
K1154 Ubiquitination PhosphoSitePlus
K1156 Ubiquitination PhosphoSitePlus
S1163 Phosphorylation phospho.ELM   UniProt 17081983
K1169 Ubiquitination PhosphoSitePlus
T1172 Phosphorylation P68400 (CSNK2A1) , P17252 (PRKCA) PhosphoSitePlus   UniProt 20335502, 21406692, 19720049, ...20068231
Y1176 Phosphorylation P12931 (SRC) phospho.ELM   PhosphoSitePlus 18669648, 12082080
R1177 Phosphorylation UniProt 21406692, 20068231
S1181 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PRO   PhosphoSitePlus   UniProt 18669648, 19720049, 8592152
S1190 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1191 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
S1194 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
S1204 Phosphorylation P28482 (MAPK1) PRO   PhosphoSitePlus 10608864
Y1211 Phosphorylation PhosphoSitePlus
Y1229 Phosphorylation P54753 (EPHB3) neXtProt   PRO   PhosphoSitePlus   RLIMS-P 12925712, 22579729
K1235 Ubiquitination PhosphoSitePlus
S1243 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1244 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T1247 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S1248 Phosphorylation P28482 (MAPK1) phospho.ELM   PRO   PhosphoSitePlus   UniProt 18669648, 10608864
Site PTM Type PTM Enzyme Score Source PMID
T518 Phosphorylation HPRD 20068231
T706 Phosphorylation HPRD 20068231
T709 Phosphorylation HPRD 20068231
N979 N-Glycosylation PRO 29671580
S1152 Phosphorylation Q15418 (RPS6KA1) HPRD 8663493
S1163 Phosphorylation HPRD 17081983
Y1176 Phosphorylation PRO 12082080
S1181 Phosphorylation P68400 (CSNK2A1) HPRD 8592152
S1190 Phosphorylation HPRD 19651622, 17081983, 20068231
S1191 Phosphorylation HPRD 19651622, 17081983, 20068231
S1194 Phosphorylation HPRD 19651622, 17081983, 20068231
S1204 Phosphorylation HPRD 20068231
S1207 Phosphorylation HPRD 20068231
S1224 Phosphorylation HPRD 20068231
S1230 Phosphorylation HPRD 20068231
S1243 Phosphorylation HPRD 18669648, 20068231
S1244 Phosphorylation HPRD 18669648, 20068231
T1247 Phosphorylation HPRD 18669648, 17081983, 20068231
S1248 Phosphorylation HPRD 18669648, 17081983, 20068231
Site PTM Type PTM Enzyme Score Source PMID
T518 Phosphorylation HPRD 20068231
T706 Phosphorylation HPRD 20068231
T709 Phosphorylation HPRD 20068231
S1152 Phosphorylation Q15349 (RPS6KA2) HPRD 8663493
T1159 Phosphorylation HPRD 17081983
S1163 Phosphorylation HPRD 17081983, 20068231
K1169 Ubiquitination PhosphoSitePlus
T1172 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231
Y1176 Phosphorylation HPRD 18669648, 17081983
S1177 Phosphorylation P68400 (CSNK2A1) HPRD   PhosphoSitePlus 18452278, 19651622, 18669648, ...8592152, 20068231
K1182 Ubiquitination PhosphoSitePlus
S1186 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231
S1187 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231
S1190 Phosphorylation HPRD   PhosphoSitePlus 19651622, 17081983, 20068231
S1200 Phosphorylation HPRD 20068231
S1203 Phosphorylation HPRD 20068231
S1220 Phosphorylation HPRD 20068231
S1226 Phosphorylation HPRD 20068231
S1239 Phosphorylation HPRD 18669648, 20068231
S1240 Phosphorylation HPRD   phospho.ELM 18669648, 20068231
T1243 Phosphorylation HPRD 18669648, 17081983, 20068231
S1244 Phosphorylation HPRD 18669648, 17081983, 20068231


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048145 (hL1CAM/SigPep-/Phos:2) pS1152 PRO
PR:000048146 (hL1CAM/SigPep-/Phos:3) pS1181 PRO
PR:000048147 (hL1CAM/SigPep-/Phos:4) pS1204,pS1248 PRO
PR:000048148 (hL1CAM/SigPep-/Phos:5) pY1229 PRO
PR:000048149 (hL1CAM/SigPep-/PhosTyr+) p PRO
PR:000026222 (hL1CAM/iso:1/SigPep-/Phos:1) pY1176 PRO 12082080


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P32004 (L1CAM) Y1229 G5E8K5 (Ank3) unknown eFIP 31640849


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K56 Q56 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ]
K140 M140 Biomuta DOID:363 / uterine cancer [ icgc ]
K180 N180 Biomuta DOID:1324 / lung cancer [ cosmic ]
K301 N301 Biomuta DOID:363 / uterine cancer [ icgc ]
Y418 N418 Biomuta DOID:184 / bone cancer [ cosmic ]
N433 I433 Biomuta [ cosmic ]
T518 S518 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
T527 A527 Biomuta DOID:1324 / lung cancer [ cosmic ]
T527 I527 Biomuta DOID:2394 / ovarian cancer [ cosmic ]
K655 R655 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K716 N716 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
Y784 H784 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
N979 I979 Biomuta DOID:4159 / skin cancer [ cosmic ]
K1154 T1154 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S1190 T1190 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1194 T1194 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S1220 L1220 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:4362 / cervical cancer [ cosmic, icgc ]
S1224 L1224 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ]