iPTMnet Report for P31947 (SFN)
Protein Information
UniProt AC / UniProt ID | P31947 / 1433S_HUMAN |
Protein Name | 14-3-3 protein sigma |
Gene Name | Name: SFN Synonyms:HME1; |
Organism | Homo sapiens (Human) |
PRO ID | PR:P31947 |
PRO Name | 14-3-3 protein sigma (human) |
Definition | A 14-3-3 protein sigma that is encoded in the genome of human. |
Short Label | hSFN |
Category | organism-gene |
P31947 (SFN) as Substrate
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
S5 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 20068231 | ||
K9 | Ubiquitination | score1 | PhosphoSitePlus | |||
K11 | Acetylation | score1 | PhosphoSitePlus | |||
K11 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y19 | Phosphorylation | score1 | PhosphoSitePlus | |||
K32 | Acetylation | score1 | PhosphoSitePlus | |||
K32 | Ubiquitination | score1 | PhosphoSitePlus | |||
C38 | S-Nitrosylation | score0 | dbSNO | 22178444 | ||
S45 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y48 | Phosphorylation | score1 | PhosphoSitePlus | |||
K49 | Acetylation | score1 | PhosphoSitePlus | |||
K49 | Ubiquitination | score1 | PhosphoSitePlus | |||
S63 | Phosphorylation | score1 | PhosphoSitePlus | |||
S64 | Phosphorylation | score1 | PhosphoSitePlus | |||
K68 | Ubiquitination | score1 | PhosphoSitePlus | |||
S69 | Phosphorylation | score1 | PhosphoSitePlus | |||
S74 | Phosphorylation | score2 | PhosphoSitePlus UniProt | 23186163 | ||
K77 | Ubiquitination | score1 | PhosphoSitePlus | |||
K87 | Ubiquitination | score1 | PhosphoSitePlus | |||
K109 | Ubiquitination | score1 | PhosphoSitePlus | |||
S116 | Phosphorylation | score1 | PhosphoSitePlus | |||
K122 | Acetylation | score1 | PhosphoSitePlus | |||
K122 | Ubiquitination | score1 | PhosphoSitePlus | |||
K124 | Ubiquitination | score1 | PhosphoSitePlus | |||
Y127 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y128 | Phosphorylation | score1 | PhosphoSitePlus | |||
T136 | Phosphorylation | score1 | PhosphoSitePlus | |||
K140 | Ubiquitination | score1 | PhosphoSitePlus | |||
K141 | Acetylation | score1 | PhosphoSitePlus | |||
S146 | Phosphorylation | score1 | PhosphoSitePlus | |||
S149 | Phosphorylation | score1 | PhosphoSitePlus | |||
Y151 | Phosphorylation | score1 | PhosphoSitePlus | |||
K159 | Acetylation | score1 | PhosphoSitePlus | |||
K160 | Ubiquitination | score1 | PhosphoSitePlus | |||
S186 | Phosphorylation | P53779 (MAPK10) , P45983 (MAPK8) , P45984 (MAPK9) | score4 | neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor | 15071501, 19220809 | |
T207 | Phosphorylation | score1 | PhosphoSitePlus | |||
S209 | Phosphorylation | score1 | PhosphoSitePlus | |||
K214 | Acetylation | score1 | PhosphoSitePlus | |||
S216 | Phosphorylation | score1 | PhosphoSitePlus | |||
T217 | Phosphorylation | score1 | PhosphoSitePlus | |||
S248 | Phosphorylation | score2 | phospho.ELM PhosphoSitePlus UniProt | 18691976, 18669648, 16964243, ... |
Site | PTM Type | PTM Enzyme | Score | Source | PMID | |
---|---|---|---|---|---|---|
M1 | Acetylation | score1 | PRO | |||
S5 | Phosphorylation | score0 | HPRD | 20068231 | ||
S146 | Phosphorylation | score0 | HPRD | 20068231 | ||
Y213 | Phosphorylation | score0 | HPRD | 20068231 | ||
S216 | Phosphorylation | score0 | HPRD | 20068231 | ||
S248 | Phosphorylation | score0 | HPRD | 18691976, 18669648, 16964243, ... |
PTM-dependent PPI
PTM type | Substrate | Site | Interactant | Association type | Source | PMID | |
---|---|---|---|---|---|---|---|
Phosphorylation | P31947 (SFN) | S186 | P00519 (ABL1) | unknown | eFIP | 19220809 |
PTM sites affected in variants
Site | Variant | Source | PMID | Disease [Sample source] |
---|---|---|---|---|
K32 | N32 | Biomuta | DOID:10534 / stomach cancer [ cosmic, icgc, tcga ] | |
K49 | N49 | Biomuta | DOID:1324 / lung cancer [ cosmic, icgc, tcga ] | |
S63 | P63 | Biomuta | DOID:10283 / prostate cancer [ cosmic ] | |
S69 | N69 | Biomuta | DOID:3070 / malignant glioma [ tcga ] | |
K140 | N140 | Biomuta | DOID:363 / uterine cancer [ tcga ] | |
S149 | L149 | Biomuta | DOID:11934 / head and neck cancer [ tcga ] |