iPTMnet Report for P31947 (SFN)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P31947 / 1433S_HUMAN
Protein Name 14-3-3 protein sigma
Gene Name Name: SFN
Synonyms:HME1;
Organism Homo sapiens (Human)

PRO ID PR:P31947
DAG View
PRO Name 14-3-3 protein sigma (human)
Definition A 14-3-3 protein sigma that is encoded in the genome of human.
Short Label hSFN
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31947 (SFN) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S5 Phosphorylation PhosphoSitePlus   UniProt 20068231
K9 Ubiquitination PhosphoSitePlus
K11 Acetylation PhosphoSitePlus
K11 Ubiquitination PhosphoSitePlus
Y19 Phosphorylation PhosphoSitePlus
K32 Acetylation PhosphoSitePlus
K32 Ubiquitination PhosphoSitePlus
S37 O-Glycosylation GlyGen 33214551, 30397120, 34725712, ...34019948, 35132862, 33465208
C38 S-Nitrosylation dbSNO 22178444
S45 Phosphorylation PhosphoSitePlus
Y48 Phosphorylation PhosphoSitePlus
K49 Acetylation PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
S63 Phosphorylation PhosphoSitePlus
S64 Phosphorylation PhosphoSitePlus
K68 Ubiquitination PhosphoSitePlus
S69 Phosphorylation PhosphoSitePlus
S74 Phosphorylation PhosphoSitePlus   UniProt 23186163
K77 Ubiquitination PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
S116 Phosphorylation PhosphoSitePlus
K122 Acetylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K124 Ubiquitination PhosphoSitePlus
Y127 Phosphorylation PhosphoSitePlus
Y128 Phosphorylation PhosphoSitePlus
Y130 Phosphorylation PhosphoSitePlus
T136 O-Glycosylation GlyGen 33214551, 30397120, 34725712, ...34019948, 35132862, 33465208
T136 Phosphorylation PhosphoSitePlus
K140 Ubiquitination PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
S149 Phosphorylation PhosphoSitePlus
Y151 Phosphorylation PhosphoSitePlus
K159 Acetylation PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
S186 Phosphorylation P53779 (MAPK10) , P45983 (MAPK8) , P45984 (MAPK9) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 15071501, 26147002, 19220809
T207 Phosphorylation PhosphoSitePlus
S209 Phosphorylation PhosphoSitePlus
K214 Acetylation PhosphoSitePlus
S216 Phosphorylation PhosphoSitePlus
T217 Phosphorylation PhosphoSitePlus
S248 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18691976, 18669648, 16964243, ...20068231
Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation PRO
S5 Phosphorylation HPRD 20068231
S146 Phosphorylation HPRD 20068231
Y213 Phosphorylation HPRD 20068231
S216 Phosphorylation HPRD 20068231
S248 Phosphorylation HPRD 18691976, 18669648, 16964243, ...20068231, 19415658


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000036163 (hSFN/Ac:1) acM1 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P31947 (SFN) S186 P00519 (ABL1) unknown eFIP 19220809


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K32 N32 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K49 N49 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S63 P63 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S69 N69 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1319 / brain cancer [ icgc ]
S74 L74 Biomuta DOID:4159 / skin cancer [ cosmic ]
K140 N140 Biomuta DOID:363 / uterine cancer [ icgc ]
S146 L146 Biomuta DOID:1324 / lung cancer [ cosmic ]
S149 L149 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S248 R248 Biomuta DOID:1319 / brain cancer [ cosmic ]