Protein Information

Cytoscape View


UniProt AC / UniProt ID P31939 / PUR9_HUMAN
Protein Name Bifunctional purine biosynthesis protein PURH
Gene Name Name: ATIC
Synonyms:PURH;ORFNames:OK/SW-cl.86;
Organism Homo sapiens (Human)

PRO ID PR:P31939
DAG View
PRO Name bifunctional purine biosynthesis protein PURH (human)
Definition A bifunctional purine biosynthesis protein PURH that is encoded in the genome of human.
Short Label hATIC
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31939 (ATIC) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 19413330
K14 Ubiquitination PhosphoSitePlus
T25 Phosphorylation PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
R42 Methylation PhosphoSitePlus
S52 Phosphorylation PhosphoSitePlus
K66 Ubiquitination PhosphoSitePlus
R79 Methylation PhosphoSitePlus
Y104 Phosphorylation Q9UM73 (ALK) phospho.ELM   PhosphoSitePlus 18083107, 18845790
K108 Ubiquitination PhosphoSitePlus
S112 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
T166 Phosphorylation PhosphoSitePlus
K177 Ubiquitination PhosphoSitePlus
T180 Phosphorylation PhosphoSitePlus
T182 Phosphorylation PhosphoSitePlus
S190 Phosphorylation PhosphoSitePlus
Y192 Phosphorylation PhosphoSitePlus
K199 Acetylation PhosphoSitePlus   UniProt 19608861
K199 Ubiquitination PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus
Y208 Phosphorylation PhosphoSitePlus
Y220 Phosphorylation PhosphoSitePlus
K254 Ubiquitination PhosphoSitePlus
S264 Phosphorylation PhosphoSitePlus
K266 Acetylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
Y290 Phosphorylation PhosphoSitePlus
Y293 Phosphorylation PhosphoSitePlus
K294 Ubiquitination PhosphoSitePlus
T295 Phosphorylation PhosphoSitePlus
T297 Phosphorylation PhosphoSitePlus
S300 Phosphorylation PhosphoSitePlus
Y303 Phosphorylation PhosphoSitePlus
R305 Methylation PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
S338 Phosphorylation PhosphoSitePlus
S355 Phosphorylation PhosphoSitePlus
K356 Acetylation PhosphoSitePlus
K356 Ubiquitination PhosphoSitePlus
K357 Ubiquitination PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
S387 Phosphorylation PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
S398 Phosphorylation PhosphoSitePlus
S401 Phosphorylation PhosphoSitePlus
T405 Phosphorylation PhosphoSitePlus
K406 Ubiquitination PhosphoSitePlus
K408 Ubiquitination PhosphoSitePlus
S413 Phosphorylation PhosphoSitePlus
T422 Phosphorylation PhosphoSitePlus
C434 S-Nitrosylation dbSNO 19483679
K437 Ubiquitination PhosphoSitePlus
K461 Ubiquitination PhosphoSitePlus
Y464 Phosphorylation PhosphoSitePlus
K477 Ubiquitination PhosphoSitePlus
K507 Sumoylation PhosphoSitePlus
K507 Ubiquitination PhosphoSitePlus
K509 Sumoylation PhosphoSitePlus
K509 Ubiquitination PhosphoSitePlus
T520 Phosphorylation PhosphoSitePlus
K524 Acetylation PhosphoSitePlus
K524 Ubiquitination PhosphoSitePlus
S537 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T25 Phosphorylation HPRD 20068231
S34 Phosphorylation HPRD 20068231
T37 Phosphorylation HPRD 20068231
Y104 Phosphorylation HPRD 18083107
T405 Phosphorylation HPRD 20068231


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S34 F34 Biomuta DOID:2394 / ovarian cancer [ icgc, tcga ] DOID:2994 / germ cell cancer [ cosmic ]
T37 S37 Biomuta DOID:1324 / lung cancer [ cosmic ]
K108 N108 Biomuta DOID:363 / uterine cancer [ tcga ]
T182 R182 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ]
T182 M182 Biomuta DOID:1909 / melanoma [ cosmic ]
S269 I269 Biomuta DOID:1324 / lung cancer [ cosmic, tcga ]
K285 R285 Biomuta DOID:363 / uterine cancer [ tcga ]
T297 S297 Biomuta DOID:3571 / liver cancer [ tcga ]
S413 Y413 Biomuta DOID:363 / uterine cancer [ tcga ]
C434 * Biomuta DOID:1319 / brain cancer [ icgc ]
Y464 * Biomuta DOID:1793 / pancreatic cancer [ tcga ]
K507 N507 Biomuta DOID:263 / kidney cancer [ tcga ]