iPTMnet Report for P31938 (Map2k1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P31938 / MP2K1_MOUSE
Protein Name Dual specificity mitogen-activated protein kinase kinase 1
Gene Name Name: Map2k1
Synonyms:Mek1,Prkmk1;
Organism Mus musculus (Mouse)

PRO ID PR:P31938
DAG View
PRO Name dual specificity mitogen-activated protein kinase kinase 1 (mouse)
Definition A dual specificity mitogen-activated protein kinase kinase 1 that is encoded in the genome of mouse.
Short Label mMAP2K1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31938 (Map2k1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S25 Phosphorylation PhosphoSitePlus
S72 Phosphorylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K175 Ubiquitination PhosphoSitePlus
K192 Ubiquitination PhosphoSitePlus
S218 Phosphorylation P28028 (Braf) , P53349 (Map3k1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 28225038, 12181353, 10749122, ...8131746, 12032835, 30862120, 12604616, 15665076, 7731726, 10409742, 8940180, 14963034, 7648369
S222 Phosphorylation P00536 (Mos) , P53349 (Map3k1) phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor 28225038, 12181353, 10749122, ...8131746, 12032835, 30862120, 12604616, 15665076, 7731726, 8940180, 14963034, 7648369
S231 Phosphorylation PhosphoSitePlus
T286 Phosphorylation P11440 (Cdk1) , Q63844 (Mapk3) , P49615 (Cdk5) phospho.ELM   PhosphoSitePlus   RLIMS-P+   UniProt 21183079, 11684694, 15665076, ...25971971
T292 Phosphorylation P63085 (Mapk1) , P53349 (Map3k1) , Q63844 (Mapk3) , P49615 (Cdk5) , P11440 (Cdk1) phospho.ELM   PhosphoSitePlus   RLIMS-P+   RLIMS-P 25971971, 8013650, 19219045, ...8019005
S298 Phosphorylation PhosphoSitePlus   RLIMS-P 28225038
K353 Ubiquitination PhosphoSitePlus
S385 Phosphorylation PhosphoSitePlus
T386 Phosphorylation P63085 (Mapk1) , Q63844 (Mapk3) PhosphoSitePlus   RLIMS-P 19607848, 8013650
T388 Phosphorylation PhosphoSitePlus


P31938 (Map2k1) as PTM Enzyme



Substrate Site Score Source PMID
P10085 (Myod1) Y156 PhosphoSitePlus 21454680
P63085 (Mapk1) T183 PhosphoSitePlus 10593929, 12167697
P63085 (Mapk1) Y185 PhosphoSitePlus 10593929, 12167697
Q63844 (Mapk3) T203 phospho.ELM   PhosphoSitePlus 12167697, 16186792, 1518847
Q63844 (Mapk3) Y205 PhosphoSitePlus 16186792, 12167697


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P31938 (Map2k1) S298 P31750 (Akt1) unknown eFIP 28225038