iPTMnet Report for P31937 (HIBADH)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P31937 / 3HIDH_HUMAN
Protein Name 3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor
Gene Name Name: HIBADH
Organism Homo sapiens (Human)

PRO ID PR:P31937
DAG View
PRO Name 3-hydroxyisobutyrate dehydrogenase, mitochondrial (human)
Definition A 3-hydroxyisobutyrate dehydrogenase, mitochondrial that is encoded in the genome of human.
Short Label hHIBADH
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31937 (HIBADH) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
S18 Phosphorylation PhosphoSitePlus
Y63 Phosphorylation PhosphoSitePlus
S88 Phosphorylation PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
K121 Acetylation PhosphoSitePlus
S127 Phosphorylation PhosphoSitePlus
S132 Phosphorylation PhosphoSitePlus
S140 Phosphorylation PhosphoSitePlus
S160 Phosphorylation HPRD   PhosphoSitePlus 20068231
K238 Acetylation PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus
K297 Acetylation PhosphoSitePlus
Y310 Phosphorylation PhosphoSitePlus
K321 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S127 L127 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S292 C292 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
S292 F292 Biomuta DOID:1324 / lung cancer [ cosmic ]