Protein Information

Cytoscape View

UniProt AC / UniProt ID P31751 / AKT2_HUMAN
Protein Name RAC-beta serine/threonine-protein kinase
Gene Name Name: AKT2
Organism Homo sapiens (Human)

PRO ID PR:P31751
DAG View
PRO Name RAC-beta serine/threonine-protein kinase (human)
Definition A RAC-beta serine/threonine-protein kinase that is encoded in the genome of human.
Short Label hAKT2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P31751 (AKT2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
M1 Acetylation UniProt 22223895
K14 Ubiquitination PhosphoSitePlus
K20 Ubiquitination PhosphoSitePlus
K30 Ubiquitination PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
Y38 Phosphorylation PhosphoSitePlus
K39 Ubiquitination PhosphoSitePlus
T81 Phosphorylation PhosphoSitePlus
K111 Ubiquitination PhosphoSitePlus
Y122 Phosphorylation PhosphoSitePlus
C124 S-Nitrosylation dbSNO 26338901
S126 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 9374542
S128 Phosphorylation PhosphoSitePlus
S131 Phosphorylation PhosphoSitePlus   RLIMS-P 29494643
T132 Phosphorylation RLIMS-P 29494643
S141 Phosphorylation PhosphoSitePlus
K142 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
K156 Ubiquitination PhosphoSitePlus
K160 Ubiquitination PhosphoSitePlus
Y177 Phosphorylation PhosphoSitePlus
Y178 Phosphorylation PhosphoSitePlus
K185 Ubiquitination PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
S242 Phosphorylation PhosphoSitePlus
K277 Ubiquitination PhosphoSitePlus
K285 Ubiquitination PhosphoSitePlus
K290 Ubiquitination PhosphoSitePlus
K298 Ubiquitination PhosphoSitePlus
S302 Phosphorylation PhosphoSitePlus
T306 Phosphorylation PhosphoSitePlus
T309 Phosphorylation Q15118 (PDK1) , O15530 (PDPK1) , P78527 (PRKDC) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   Signor   UniProt 23912456, 20059950, 15743829, ...15678105, 9512493, 15191648, 15890450, 32061436, 12434148, 24169049
T313 Phosphorylation PhosphoSitePlus
Y316 Phosphorylation PhosphoSitePlus
Y327 Phosphorylation PhosphoSitePlus
K378 Acetylation PhosphoSitePlus
K378 Ubiquitination PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
Y438 Phosphorylation PhosphoSitePlus
S447 Phosphorylation PhosphoSitePlus   UniProt 19690332
T449 Phosphorylation PhosphoSitePlus
T451 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 19690332, 24275569, 9374542
Y456 Phosphorylation PhosphoSitePlus
S458 Phosphorylation PhosphoSitePlus
S474 Phosphorylation O15530 (PDPK1) , P78527 (PRKDC) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25304263, 26701849, 9374542, ...24150286, 29258530, 15743829, 10822383, 15890450, 15010337, 19690332, 23912456, 20059950, 22657251, 29266303, 15678105, 31548312, 30721135, 29658179, 23478189, 26475619, 24169049
Y475 Phosphorylation PhosphoSitePlus
S476 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus   UniProt 19690332
Site PTM Type PTM Enzyme Score Source PMID
S126 Phosphorylation HPRD 18669648, 9374542
T309 Phosphorylation O15530 (PDPK1) HPRD 12048203, 9374542
T451 Phosphorylation HPRD 9374542
S474 Phosphorylation O15530 (PDPK1) HPRD 11723139, 12048203, 9374542
S476 Phosphorylation HPRD 15144186
S478 Phosphorylation HPRD 15144186

P31751 (AKT2) as PTM Enzyme

Substrate Site Score Source PMID
O15111 (CHUK) T23 HPRD   neXtProt   PhosphoSitePlus   Signor 19609947, 12048203
O43464 (HTRA2) S212 neXtProt   PhosphoSitePlus   Signor 17311912
O43524 (FOXO3) T32 Signor 19188143
O43524 (FOXO3) S253 Signor 19188143
O43524 (FOXO3) S315 Signor 19188143
O60331 (PIP5K1C) S555 PhosphoSitePlus 26149501
P03372 (ESR1) S167 HPRD   neXtProt   PhosphoSitePlus 11139588, 11432835, 11507039, ...9528769
P04406 (GAPDH) T237 PhosphoSitePlus 21979951
P04792 (HSPB1) S82 Signor 19593530
P15056 (BRAF) S364 Signor 10869359
P15056 (BRAF) S428 Signor 10869359
P15056 (BRAF) T440 Signor 10869359
P15311 (EZR) T567 PhosphoSitePlus   Signor 15531580
P16220 (CREB1) S119 Signor 9829964
P28906 (CD34) S346 neXtProt 21499536
P29474 (NOS3) S615 Signor 24379783
P30405 (PPIF) S31 PhosphoSitePlus 25650317
P35222 (CTNNB1) S552 neXtProt   PhosphoSitePlus   Signor 17287208
P46527 (CDKN1B) T157 Signor 12244303
P49760 (CLK2) T344 neXtProt 20074525
P49815 (TSC2) S939 Signor 12150915, 19188143, 12172553
P49815 (TSC2) T1462 Signor 12150915, 19188143, 12172553
P49841 (GSK3B) S9 Signor 23552696
P55211 (CASP9) S196 Signor 9812896, 15004527
P68431 (H3C12) S11 neXtProt 22158034
P68431 (H3C12) S29 neXtProt 22158034
P68431 (H3C12) T46 neXtProt 22158034
P98170 (XIAP) S87 HPRD   neXtProt   PhosphoSitePlus   Signor 14645242
P98177-1 (FOXO4) T32 HPRD   Signor 16272144, 19664994, 11313479
Q00987 (MDM2) S166 Signor 11504915
Q00987 (MDM2) S186 Signor 11504915
Q01860 (POU5F1) T235 Signor 23041284
Q09472 (EP300) S1834 Signor 16926151
Q12778 (FOXO1) T24 Signor 10377430
Q12778 (FOXO1) S256 Signor 10377430
Q13043 (STK4) T387 Signor 23431053
Q13188 (STK3) T117 Signor 20231902
Q13243 (SRSF5) S86 neXtProt 15684423
Q13541 (EIF4EBP1) T36 neXtProt 20227039
Q13541 (EIF4EBP1) T45 neXtProt 20227039
Q14315 (FLNC) S2233 neXtProt   PhosphoSitePlus 15461588
Q15365 (PCBP1) S43 RLIMS-P+ 24072492
Q6ZWJ1 (STXBP4) S99 neXtProt 15753124
Q7Z6J0 (SH3RF1) S304 neXtProt   PhosphoSitePlus   Signor 17535800
Q86YS7 (C2CD5) S197 PhosphoSitePlus 21907143
Q8WX93 (PALLD) S1118 neXtProt 20471940
Q92908-2 (GATA6) S290 PhosphoSitePlus 25969542
Q92934 (BAD) S99 Signor 10949026
Q92934 (BAD) S118 Signor 10949026
Q92945 (KHSRP) S193 neXtProt   PhosphoSitePlus 17177604
Q96B36 (AKT1S1) T246 Signor 12524439
Q96F86 (EDC3) S161 neXtProt   PhosphoSitePlus 20051463
Q99683 (MAP3K5) S83 neXtProt   PhosphoSitePlus   Signor 12697749
Q99697 (PITX2) T90 neXtProt 20019746
Q9GZV1 (ANKRD2) S99 neXtProt   PhosphoSitePlus 21737686
Q9H0H5 (RACGAP1) T249 PhosphoSitePlus 24019536
Q9H0K1 (SIK2) S358 neXtProt 17805301
Q9NZJ5 (EIF2AK3) T802 neXtProt 21954288
Q9UBK2 (PPARGC1A) S571 Signor 17554339
Q9Y3M2 (CBY1) S20 neXtProt   PhosphoSitePlus 18573912
Q9Y4I1 (MYO5A) T1650 neXtProt 17515613


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046298 (hAKT2/Phos:1) pS474 PRO
PR:000046299 (hAKT2/Phos:2) pT309 PRO
PR:000046300 (hAKT2/Phos:3) pT309,pS474 PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K30 N30 Biomuta DOID:4362 / cervical cancer [ tcga ]
K277 N277 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
T309 N309 Biomuta DOID:3571 / liver cancer [ icgc ]
K378 T378 Biomuta DOID:0070003 / blastoma [ cosmic ]
K378 N378 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S447 F447 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S474 F474 Biomuta DOID:1909 / melanoma [ icgc, tcga ]