iPTMnet Report for P31750 (Akt1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P31750 / AKT1_MOUSE
Protein Name RAC-alpha serine/threonine-protein kinase
Gene Name Name: Akt1
Synonyms:Akt,Rac;
Organism Mus musculus (Mouse)

PRO ID PR:P31750
DAG View
PRO Name RAC-alpha serine/threonine-protein kinase (mouse)
Definition A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of mouse.
Short Label mAKT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31750 (Akt1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Y18 Phosphorylation RLIMS-P 27689988
Y26 Phosphorylation RLIMS-P 20103705
K30 Ubiquitination PhosphoSitePlus
T34 Phosphorylation RLIMS-P 17335965
T117 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
S124 Phosphorylation phospho.ELM   PhosphoSitePlus 17242355
S126 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 17242355, 26146542
S129 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 17242355, 26739490, 29725001, ...21183079
S137 Phosphorylation PhosphoSitePlus
T172 Phosphorylation RLIMS-P 32566257
Y176 Phosphorylation O54967 (Tnk2) PhosphoSitePlus   RLIMS-P   UniProt 20333297
T195 Phosphorylation Q9WUN2 (Tbk1) RLIMS-P+ 25606824
K276 Ubiquitination PhosphoSitePlus
T305 Phosphorylation PhosphoSitePlus
T308 O-Glycosylation GlyGen   PhosphoSitePlus 24526702, 30031227, 33915326, ...26866564, 23793825, 11959983, 18570920
T308 Phosphorylation Q9Z2A0 (Pdpk1) , Q63844 (Mapk3) , P47811 (Mapk14) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 24280772, 26809587, 28821740, ...29311937, 26491103, 28123341, 27226588, 26121028, 29494346, 32796834, 36198369, 22253608, 24621388, 32312949, 28294959, 25752217, 24116102, 11803463, 34366869, 19369943, 25888638, 25463972, 22933110, 20179753, 11507090, 33012785, 24734904, 24987368, 30578122, 25332884, 24967341, 24126057, 22403300, 28018219, 32783890, 23275438, 22710723, 29358916, 33897895, 19432987, 15389876, 11375936, 27534430, 28086800, 35122865, 23451056, 22117619, 25214523, 36297523, 19627269, 28346493, 22685300, 19761830, 20586915, 27176481, 20622167, 30103648, 19844585, 27344443, 29184057, 23940776, 27412013, 25132272, 25377878, 31767180, 15065872, 23964069, 26438830, 24775271, 25394413, 26503303, 31420304, 27734117, 26359501, 20661274, 32518366, 26813160, 15504738, 27248324, 26872208, 29700562, 32641498, 19047061, 23029230, 15753085, 27001940, 25162417, 15842198, 17190838, 25336920, 28440748, 25646773, 24435134, 27542970, 32859869, 32493400, 29159980, 15278907, 33486894, 12947100, 27000529, 25780086, 31112530, 19657063, 33038070, 31918924, 23671593, 20976192, 10438924, 24505362, 12682057, 28883758, 20028942, 20363892, 26743335, 32422541, 26503641, 26278110, 18332223, 21642988, 25799367, 15067018, 28878342, 12388598, 33669811, 23251519, 27893783, 23593332, 25826083, 32046324, 19587782, 29121094, 24150605, 28209968, 31474552, 32483262, 11006271, 23874604, 33500390, 33414476, 20719961, 24286194, 28350865, 29487597, 23390495, 28395173, 30018139, 23493568, 28875936, 27876711, 25558238, 33941789, 33869980, 22496778, 29180704, 27127181, 31614949, 26263164, 29472543, 28322786, 31924750, 26876212, 25379771, 31652791, 33931442, 14623889, 15574782, 31534518, 30988282, 28933316, 22652602, 32728173, 19065678, 23907468, 26928911, 32075060, 18757368, 17924178, 23251389, 33633735, 27765055, 29920520, 22218715, 16787946, 25056877, 9927197, 24068707, 21655268, 33214645, 29241457, 30413815, 24722238, 33184414, 31307481, 33649479, 27099352, 33071755, 29853881, 23049865, 24670364, 23239877, 20847051, 30635036, 33210868, 24649407, 22773877, 22132131, 28152035, 27485212, 16809629, 22733590, 12493740, 33226552, 18177853, 29962852, 25790465, 21927580, 21859896, 28264587, 16338957, 22028912, 17967879, 35224167, 15020199, 29769144, 31470507, 29930536, 25606824, 11563975, 29109428, 29560100, 33629064, 27253992, 29453154, 26880110, 24340073, 28759639, 28386126, 32373532, 23469174, 28665395, 20188786, 31949275, 26412745, 28874678, 32163656, 33413592, 27257474, 22428049, 25415296, 27689988, 22606274, 33275593, 35748215, 30391964, 20386333, 16872509, 25084011, 30279732, 12153489, 29118722, 24740015, 29860106, 27384491, 29433422, 24434432, 23311350, 21906027, 24156551, 19731018, 11087733, 26687764, 22412835, 21926268, 22184110, 33177089, 29535623, 32101748, 32566257, 28225038, 29855474, 20971978, 15364915, 21571071, 30823934, 29662189, 25826077, 31141608, 18952837, 26553931, 25853295, 23444402, 30211334, 33435535, 22941977, 31246957, 22418434, 22693641, 32153410, 22586587, 30696333, 25221930, 17371830, 28424421, 17977562, 23386984, 28243164, 12911789, 31398213, 26720454, 25546475, 30065170, 12637511, 26249804, 18171481, 27009084, 31915252, 17141160, 31182807, 25594415, 24945938, 27477105, 24068327, 22832498, 23554947, 30384400, 22019461, 31767175, 25880554, 15082758, 20587420, 28560349, 28368423, 24662050, 24670654, 26554359, 23071621, 36405694, 20103705, 17220321, 29725001, 30429249, 29057818, 25398386, 26959121, 19761823, 36148310, 33993653, 24944899, 27197158, 28426713, 24810050, 24349514, 29872253, 24101676, 31337981, 28591208, 22476915, 24280377, 30237867, 33184378, 20333297, 22359505, 24351823, 21266327, 25808491, 16512910, 32194423, 28123943, 26909311, 21670491, 35477177, 23716717, 32366272, 33595435, 17287469, 27167344, 23750258, 31399584, 33348907, 15591229, 23622715, 19077278, 15122342, 29500670, 17339838, 27070899, 30442153, 23935891, 22412912, 22792172, 25531328, 28987868, 25568666, 31570855, 29867489, 24647338, 18288188
T312 Phosphorylation PhosphoSitePlus
Y315 Phosphorylation P05480 (Src) phospho.ELM   PhosphoSitePlus   RLIMS-P 20606012, 11445557
Y326 Phosphorylation P05480 (Src) phospho.ELM   PhosphoSitePlus   RLIMS-P 20606012, 11445557, 24675832
S378 Phosphorylation Q9WUN2 (Tbk1) RLIMS-P+ 25606824
T389 Phosphorylation RLIMS-P 16984645, 20661274, 27549161, ...28212537, 27127181
S396 Phosphorylation RLIMS-P 30823934
S422 Phosphorylation RLIMS-P 26848623
T430 O-Glycosylation GlyGen 24526702, 30031227, 33915326, ...26866564, 23793825, 11959983, 18570920
T430 Phosphorylation RLIMS-P 24526702
T450 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 21045808, 21670491, 28440748, ...26263164
S473 O-Glycosylation GlyGen   PhosphoSitePlus   UniProt 18570920
S473 Phosphorylation P31750 (Akt1) , P20444 (Prkca) , Q9JLN9 (Mtor) , P97313 (Prkdc) , P47811 (Mapk14) phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 24280772, 28821740, 26809587, ...20856813, 28123341, 27226588, 33688389, 29311937, 32038161, 26121028, 27435826, 25839650, 29494346, 32796834, 26907332, 36198369, 31420304, 22590527, 22253608, 32911704, 31233346, 24142192, 20332342, 24621388, 28319140, 32312949, 27930667, 23300339, 25752217, 14997210, 31821410, 17000928, 23236519, 34366869, 28425986, 24351823, 22933110, 31213670, 16397046, 25168244, 28373901, 28331616, 25141786, 28700632, 22934083, 28364027, 20179753, 11507090, 32350463, 33012785, 26135741, 24734904, 32341362, 28542434, 19291319, 30578122, 25332884, 24967341, 28461774, 27935220, 32581790, 36325883, 35907465, 15517884, 28870245, 32783890, 24557881, 18391484, 23965299, 29657993, 22734004, 19013131, 34988938, 28632169, 19432987, 22859500, 29364220, 11950275, 10974038, 25672620, 27562094, 33758172, 23451056, 22117619, 25214523, 26249804, 19627269, 28346493, 33672385, 19761830, 20586915, 29472543, 27176481, 29486284, 20622167, 22412882, 19844585, 27344443, 31827703, 29057818, 20811625, 27412013, 25132272, 25377878, 31767180, 21408125, 23598407, 23964069, 24223757, 32276588, 20705918, 30556043, 25888638, 26801880, 10722653, 24832603, 33804171, 15550174, 25279552, 27734117, 26359501, 16845229, 15504738, 25136373, 29239329, 27248324, 24260338, 32127592, 32641498, 28490443, 21993375, 26523428, 26000908, 23029230, 26984741, 33758188, 15753085, 27001940, 24985103, 29763645, 18350159, 15842198, 17190838, 28834262, 22900024, 25336920, 28440748, 25646773, 25240598, 24435134, 29464929, 27542970, 32859869, 25162417, 27980227, 32493400, 33419082, 29159980, 15278907, 31161862, 26454089, 30626204, 12947100, 30509210, 16180585, 27778132, 23852728, 31112530, 31980707, 31918924, 23671593, 20976192, 16618793, 23478138, 10438924, 17409645, 24505362, 28883758, 23868942, 15935620, 27050422, 20028942, 24746698, 20363892, 26743335, 27940127, 27966074, 26278110, 33846776, 22532369, 32316601, 25635326, 29170374, 24052072, 20174572, 15067018, 19745829, 28878342, 28294959, 33669811, 28243164, 27893783, 23593332, 15845623, 10747954, 22559167, 32046324, 19587782, 14581607, 24150605, 28978011, 16831409, 19365570, 19847197, 32483262, 11006271, 23874604, 33500390, 28285180, 33807180, 22057724, 30554658, 20719961, 24116102, 24286194, 28350865, 29487597, 28933316, 21847101, 28710412, 25965336, 32956848, 33520717, 35766003, 23390495, 19416348, 14657000, 26095253, 23493568, 25968579, 28875936, 27876711, 33941789, 31771622, 19246681, 33869980, 31918917, 26936863, 22496778, 26100075, 18086904, 19369943, 33677938, 31614949, 27897407, 26263164, 31366324, 33884100, 29530069, 31924750, 26876212, 29384221, 31857853, 25379771, 31182914, 15692086, 11018758, 20338882, 11062251, 34465724, 33931442, 14623889, 25460003, 18288891, 25280966, 31624287, 28386, 11740206, 32719388, 29035165, 30988282, 27335054, 25775433, 22652602, 32728173, 24334165, 33613308, 28783756, 23907468, 26928911, 32075060, 23734002, 30717198, 30022023, 33362773, 18757368, 25004182, 17924178, 23251389, 19434632, 32792672, 20362052, 33633735, 27765055, 29920520, 22218715, 25965947, 24068707, 21655268, 32596245, 32891670, 29123170, 21511697, 22910893, 23519033, 32085796, 27799485, 24008733, 28230282, 18198353, 24722238, 30250638, 23443503, 28329851, 33184414, 31307481, 24757676, 33649479, 27099352, 25564616, 29535720, 31215459, 30972066, 27634219, 29853881, 28489892, 23049865, 30402124, 18411306, 31279779, 30186439, 23748360, 20847051, 30635036, 20333297, 24649407, 22773877, 17141160, 24067903, 32983109, 28152035, 27485212, 24629015, 25991723, 23133640, 30005372, 16338928, 24675832, 22733590, 12493740, 24052499, 33226552, 21106850, 18177853, 24367658, 10714768, 25790465, 24987368, 20813836, 27207782, 21927580, 33005011, 28264587, 33062046, 16338957, 22028912, 22936801, 17967879, 18523362, 23369342, 25714556, 23702782, 29769144, 28835690, 29133930, 31470507, 31931851, 35023763, 20543991, 29930536, 9927197, 11563975, 25416469, 17210832, 29560100, 21407213, 24945834, 32173345, 27253992, 29453154, 26880110, 24340073, 32427102, 25466188, 28759639, 31551760, 18566543, 21479224, 11570877, 28209968, 33567340, 27257474, 32873626, 32531473, 33275593, 30014636, 17195063, 20691662, 30696333, 18332223, 30078230, 20936097, 27213961, 15364915, 27849007, 23489026, 28209725, 26023930, 27430312, 27994061, 18718531, 32153410, 29775456, 23251519, 33033766, 26720454, 31915252, 22132131, 30409162, 31929511, 31167373, 25880554, 15082758, 28368423, 31155593, 32899862, 30936879, 32615737, 28426713, 31337981, 12783884, 32379706, 33184378, 23188702, 26107252, 27457910, 26728896, 20022531, 30231545, 16221682, 30410062, 31570855, 29867489, 15389876
Y474 Phosphorylation PhosphoSitePlus
S475 Phosphorylation PhosphoSitePlus
S477 Phosphorylation PhosphoSitePlus   RLIMS-P 24670654
T479 O-Glycosylation GlyGen 24526702, 30031227, 33915326, ...26866564, 23793825, 11959983, 18570920
T479 Phosphorylation PhosphoSitePlus   RLIMS-P 24526702, 24670654


P31750 (Akt1) as PTM Enzyme



Substrate Site Score Source PMID
O88643 (Pak1) S21 PhosphoSitePlus 14585966
P17679 (Gata1) S310 PhosphoSitePlus 16204311
P23804 (Mdm2) S163 PhosphoSitePlus 25526089
P30306 (Cdc25b) S351 PhosphoSitePlus 17554083
P31750 (Akt1) S473 PhosphoSitePlus 11570877, 10722653
P35821 (Ptpn1) S50 Signor 11579209
P47809 (Map2k4) S78 PhosphoSitePlus 25594179
P48432 (Sox2) T118 RLIMS-P+ 25042802
P62509 (Esrrg) S179 PhosphoSitePlus 25205222
P62754 (Rps6) S236 PhosphoSitePlus 12151408
Q02248 (Ctnnb1) S552 PhosphoSitePlus 20230753
Q0VGT2 (Gli2) S230 PhosphoSitePlus 25825734
Q60700 (Map3k12) S584 PhosphoSitePlus 25802931
Q60700 (Map3k12) T659 PhosphoSitePlus 25802931
Q60760 (Grb10) S455 PhosphoSitePlus 15722337
Q60949 (Tbc1d1) T590 PhosphoSitePlus 18215134
Q61037 (Tsc2) S939 PhosphoSitePlus   Signor 12150915, 17460049
Q61037 (Tsc2) T1465 Signor 12150915
Q61337 (Bad) S112 PhosphoSitePlus 9381178, 11723239
Q61337 (Bad) S136 PhosphoSitePlus 12087097, 15123689, 10949026, ...9381178, 9346240
Q61337 (Bad) S155 PhosphoSitePlus 15123689, 10949026
Q61409 (Pde3b) S273 PhosphoSitePlus 10454575
Q8BYJ6 (Tbc1d4) T649 PhosphoSitePlus 16935857
Q8CFH6 (Sik2) S358 PhosphoSitePlus 17805301
Q91V92 (Acly) S455 PhosphoSitePlus 16007201
Q99N57 (Raf1) S259 PhosphoSitePlus 12087097
Q9JID9 (Sh2b2) S588 Signor 16141217
Q9QYG0 (Ndrg2) T348 PhosphoSitePlus 14985363
Q9R1E0 (Foxo1) T24 PhosphoSitePlus 11570877, 10377430
Q9R1E0 (Foxo1) S253 PhosphoSitePlus 10377430, 11375271
Q9R1E0 (Foxo1) S316 PhosphoSitePlus 11570877
Q9WV60 (Gsk3b) S9 PhosphoSitePlus 12095987
Q9WVH3 (Foxo4) S197 Signor 10217147
Q9WVH3 (Foxo4) S262 Signor 10217147
Q9WVH4 (Foxo3) T32 PhosphoSitePlus 10102273
Q9Z1T6 (Pikfyve) S48 PhosphoSitePlus 23905686
Q9Z1T6 (Pikfyve) S307 PhosphoSitePlus 23905686


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049940 (mAKT1/Phos:3) pS473 PRO 27994061
PR:000050596 (mAKT1/Phos:1) pT308,pS473 PRO 31915252


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P31750 (Akt1) S473 Q9R1E0 (Foxo1) unknown eFIP 29410630
Phosphorylation P31750 (Akt1) S473 Q9WVH4 (Foxo3) decreased_association eFIP 24067903
Phosphorylation P31750 (Akt1) T308 Q6P5G0 (Mapk4) unknown eFIP 33088477
Phosphorylation P31938 (Map2k1) S298 P31750 (Akt1) unknown eFIP 28225038
Phosphorylation Q63932 (Map2k2) S306 P31750 (Akt1) unknown eFIP 28225038