Protein Information

Cytoscape View


UniProt AC / UniProt ID P31749 / AKT1_HUMAN
Protein Name RAC-alpha serine/threonine-protein kinase
Gene Name Name: AKT1
Synonyms:PKB,RAC;
Organism Homo sapiens (Human)

PRO ID PR:P31749
DAG View
PRO Name RAC-alpha serine/threonine-protein kinase (human)
Definition A RAC-alpha serine/threonine-protein kinase that is encoded in the genome of human.
Short Label hAKT1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31749 (AKT1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus   RLIMS-P 26440416, 24467442
K8 Ubiquitination PhosphoSitePlus
K14 Acetylation UniProt 21775285
K14 Methylation PhosphoSitePlus
K14 Ubiquitination PhosphoSitePlus
K20 Acetylation UniProt 21775285
K30 Ubiquitination PhosphoSitePlus
T34 Phosphorylation Q05513 (PRKCZ) neXtProt   PhosphoSitePlus   RLIMS-P 14560023, 25912234
T65 Phosphorylation PhosphoSitePlus
T72 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   RLIMS-P 16549426
T87 Phosphorylation PhosphoSitePlus
T92 Phosphorylation PhosphoSitePlus
S122 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S124 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 12149249, 18669648, 24670416, ...27769065
S126 O-Glycosylation PhosphoSitePlus   UniProt 22629392
S126 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S129 O-Glycosylation PhosphoSitePlus   UniProt 22629392
S129 Phosphorylation P68400 (CSNK2A1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21735093, 23186163, 17081983, ...26641458, 21159648, 24769357, 15818404, 18669648, 25153725, 19662498, 24023938, 26919095, 24670416
S137 Phosphorylation PhosphoSitePlus
T146 Phosphorylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
T172 Phosphorylation RLIMS-P 26304753
Y176 Phosphorylation Q07912 (TNK2) neXtProt   PhosphoSitePlus   RLIMS-P   UniProt 20432460, 20333297, 22322295
T211 Phosphorylation PhosphoSitePlus   RLIMS-P 23768697
S216 Phosphorylation RLIMS-P 22759359
C224 S-Nitrosylation dbSNO 15632167, 22178444
S246 Phosphorylation P31749 (AKT1) neXtProt   PhosphoSitePlus   RLIMS-P 16549426
K276 Sumoylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K284 Ubiquitination UniProt 22410793
T291 Phosphorylation PhosphoSitePlus   RLIMS-P 23768697
C296 S-Nitrosylation dbSNO 16041729, 22178444
K301 Sumoylation PhosphoSitePlus
T305 O-Glycosylation PhosphoSitePlus   UniProt 22629392
T305 Phosphorylation PhosphoSitePlus   RLIMS-P 22629392
T308 O-Glycosylation PhosphoSitePlus
T308 Phosphorylation P78527 (PRKDC) , P17252 (PRKCA) , Q9UHD2 (TBK1) , P05771 (PRKCB) , Q15139 (PRKD1) , Q8N5S9 (CAMKK1) , Q14164 (IKBKE) , O15530 (PDPK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 25722288, 21321187, 21763075, ...20385969, 17198778, 26243309, 26485768, 23529222, 25622969, 25220506, 23922669, 25418727, 26378810, 24622734, 18006659, 11752635, 19262695, 25153728, 15738003, 12835332, 24585214, 12429987, 23596569, 25912234, 17910952, 26945062, 26111001, 23100325, 27176505, 24416349, 12388598, 23300339, 27773936, 26137586, 17028898, 9859994, 26290457, 23151908, 24611062, 21295499, 17684018, 16585200, 25784113, 23285163, 22335604, 27769069, 24446434, 18801898, 25569101, 23419269, 25375133, 23570421, 20026151, 27894090, 23705826, 20186153, 21325624, 23613850, 21908616, 18557931, 20952497, 22902327, 8978681, 23167739, 25624750, 27626683, 21908613, 27624942, 12167717, 17158952, 11896604, 16169930, 23799035, 12149249, 26959555, 23402310, 16168126, 11874713, 22739265, 27390173, 17826953, 16044149, 24057571, 28035333, 16636147, 27412013, 21300751, 21724622, 24456610, 19166928, 26848620, 15289499, 16306364, 19112161, 25212826, 25688212, 23928696, 20532215, 20153512, 28188308, 18456494, 26919095, 22685542, 10722653, 23623968, 26852666, 19039330, 24107614, 21402788, 27901111, 27220846, 22107784, 23892273, 18725974, 19238332, 22322917, 11389054, 22403297, 25385184, 24280348, 23272152, 27102439, 20944421, 23802099, 14679308, 22039466, 26313911, 27192118, 16100524, 22771387, 20686178, 23681745, 23979601, 27494895, 23119004, 21559502, 27074558, 17883592, 15157674, 21364639, 26682007, 24428908, 17407381, 26607178, 17971124, 20585660, 20054340, 26746999, 18332867, 24615340, 19153210, 12682057, 24454800, 22029423, 20375905, 16763222, 11877406, 23085420, 20400975, 12654898, 28036265, 15026145, 26751215, 28003335, 22839755, 25352995, 22110663, 18838385, 21750219, 23263555, 22905719, 20106927, 21097843, 15641106, 27494022, 19166270, 19661305, 23077590, 24150605, 16299382, 21705677, 24418989, 26646023, 23396361, 20081374, 26934444, 18391071, 20205745, 17339610, 27531894, 12176337, 24260384, 24581231, 27829222, 11465707, 19099901, 18443205, 26317547, 24349321, 20361045, 23849428, 21798082, 21668414, 25678401, 27187380, 26483070, 20938636, 17848913, 19675138, 27026523, 11042204, 23448424, 23192081, 25793983, 16543232, 10716737, 27649272, 19055752, 27239959, 22245935, 22422409, 22809628, 15574783, 15545271, 25767601, 26415504, 19726058, 28035062, 12808134, 27137757, 17098228, 21496273, 26121251, 22031698, 20950443, 25228590, 20517722, 22529978, 19402821, 23912456, 20054000, 11546775, 25311506, 22139837, 25611382, 27765055, 16183860, 21505451, 19293927, 19574502, 21078168, 24073922, 26824321, 20169162, 19074832, 17556533, 27285760, 16046309, 22363598, 17977950, 15026550, 18204829, 12556562, 20860815, 22473959, 27047993, 26506516, 24649407, 24358196, 25997832, 19779850, 27294151, 24377058, 19052636, 22690138, 25961827, 19465931, 17468516, 24232099, 20481595, 12493740, 20183800, 10874027, 22871047, 23668972, 16987514, 22337773, 20975834, 21818627, 25388642, 19633130, 11274160, 24413065, 19472218, 24091816, 9445477, 11825911, 17594810, 24625973, 20489726, 23091605, 12034358, 27622707, 23045700, 27397543, 23303682, 26201515, 26801686, 19644030, 26023089, 21445305, 28189993, 28179017, 24992302, 16684529, 25098276, 12637511, 15191562, 26528819, 14568991, 26025205, 27027448, 26124182, 25296502, 26880110, 27015152, 27966531, 10698939, 23979838, 25915946, 24705275, 22207758, 26130968, 18054038, 18795165, 17234785, 17928291, 24654606, 18199958, 10926925, 20299475, 18838554, 26517515, 22975683, 12351701, 10415336, 24018901, 18477468, 18197291, 19307602, 16275989, 18691227, 21732756, 10226029, 25313141, 28072855, 12686550, 27903983, 21804606, 25432075, 27903985, 11731021, 12164932, 23274898, 25247416, 26613407, 19446470, 27379204, 15183529, 21592956, 24900620, 26741489, 22509246, 27211495, 25999352, 23976954, 27207509, 25792811, 18305032, 27076174, 18931031, 24374242, 20643654, 16761106, 14572154, 22912850, 27636107, 28231291, 26988603, 20039275, 17313857, 20494139, 16419156, 20333467, 25880247, 25551293, 11278269, 11313365, 22460505, 24979261, 20163786, 25105067, 9868760, 19255520, 22248929, 28231796, 16940331, 26046303, 24247980, 27323778, 28209923, 20352231, 27659528, 15372623, 16306447, 15364915, 25355053, 24023938, 17615157, 22487004, 26356562, 23953418, 11162641, 17096325, 21464307, 20980511, 25826077, 24039912, 21666717, 17259384, 22830422, 24467442, 20383279, 16531397, 28129639, 23951353, 25273559, 25026292, 16987028, 23840605, 20334367, 26974310, 26535060, 25531880, 27346647, 17400190, 25965345, 19233842, 26557719, 10833263, 15327518, 25136826, 15456405, 25564612, 16330671, 21514425, 19158829, 23989949, 27147579, 25569743, 15913452, 23436801, 11893783, 26657992, 24188406, 22927331, 19320971, 25196260, 26497682, 11007949, 22347457, 21625639, 23650507, 23415012, 9094314, 21698202, 22787432, 20150288, 17041888, 22510297, 20454577, 26440416, 26821351, 25528216, 20540782, 25719244, 24365180, 9368760, 16549426, 25749514, 20051961, 23243000, 26910892, 15150572, 24113173, 22569334, 28232663, 22957045, 21415306, 23049696, 27601656, 15767780, 27793011, 12373610, 9857186, 24156551, 21600875, 23427269, 25640278, 22629392, 23933705, 23844554, 27004402, 25654224, 24273605, 16731842, 27004406, 20520724, 19422047, 24816687, 21565140, 25639875, 12208782, 24933731, 9512493, 22880048, 18262492, 17548608, 22379109, 20836557, 23285096, 26408176, 25974307, 23155381, 23580233, 24023012, 15047842, 21329883, 25965823, 26832662, 22173970, 9632753, 21131356, 23748344, 24561239, 27954090, 26903300, 28061880, 27053161, 24392034, 26600389, 21278786, 27391443, 20333297, 17960559, 16916597, 21767636, 22415553, 15678105, 23684622, 27611696, 19602588, 10226025, 26514724, 23030823, 16103100, 26244501, 24352480, 24169049, 24670043, 19740993, 23071583, 20421190, 12939297, 26402468, 27494886, 26967055, 15998799, 27811362, 26073086, 19211028, 27430155, 24797432, 26942872, 23469007, 18409144, 21660042, 23182460, 26891914, 11020382, 24516643, 12000750, 11359783, 24618420, 26235620, 24372645, 21956113, 15718470, 26110849, 16288304, 19996208, 19302240, 25980493, 11358816, 15505622, 21867682, 22567414
C310 S-Nitrosylation dbSNO 16041729, 22178444
T312 O-Glycosylation PhosphoSitePlus   UniProt 22629392
T312 Phosphorylation P49840 (GSK3A) PhosphoSitePlus   RLIMS-P 23142783, 22629392
Y315 Phosphorylation Q13882 (PTK6) , P12931 (SRC) , P07949 (RET) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor 20606012, 22379109, 12600984, ...26443198, 11445557, 15994200
Y326 Phosphorylation P12931 (SRC) , Q13882 (PTK6) neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor 20606012, 22379109, 26443198, ...11445557, 23059825
K377 Ubiquitination PhosphoSitePlus
S378 Phosphorylation PhosphoSitePlus
S396 Phosphorylation PhosphoSitePlus
Y417 Phosphorylation PhosphoSitePlus
K420 Acetylation PhosphoSitePlus
K426 Acetylation PhosphoSitePlus
T435 Phosphorylation PhosphoSitePlus   RLIMS-P 23902692
Y437 Phosphorylation PhosphoSitePlus
T443 Phosphorylation PhosphoSitePlus
T448 Phosphorylation PhosphoSitePlus   UniProt 24275569
T450 Phosphorylation P42345 (MTOR) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 21724622, 20186153, 25243120, ...24705275, 18762023, 23922774, 10874027, 27654866, 26891914, 21045808, 24275569, 27239959, 23684622, 12149249, 26751215, 22771387, 19402821
S457 Phosphorylation PhosphoSitePlus
S473 O-Glycosylation PhosphoSitePlus
S473 Phosphorylation P05771 (PRKCB) , Q9UHD2 (TBK1) , P78527 (PRKDC) , Q9Y2I7 (PIKFYVE) , Q14164 (IKBKE) , P17252 (PRKCA) , Q5S007 (LRRK2) , O15530 (PDPK1) , Q13418 (ILK) , Q15139 (PRKD1) , P42345 (MTOR) , P49137 (MAPKAPK2) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 24284390, 24812621, 21321187, ...15867245, 22363436, 21658387, 21763075, 20385969, 25912234, 21177249, 22305966, 26919095, 24918199, 16731842, 12200236, 15047168, 25722288, 24396487, 23529222, 25622969, 25220506, 24159375, 23922669, 8978681, 15944217, 18687633, 24179530, 22590625, 18455702, 18006659, 26674329, 24526702, 25190803, 19483721, 19057672, 19262695, 25153728, 10625301, 28209923, 23300998, 25687330, 24585214, 24002438, 12429987, 26248315, 25997619, 23739679, 23596569, 17910952, 25590801, 16537601, 26945062, 24178756, 19615971, 26111001, 23100325, 18159236, 26496029, 23596468, 21775480, 21321111, 15706421, 22728372, 21291561, 17007924, 23300339, 27773936, 26137586, 24804268, 17028898, 21668414, 12181443, 26290457, 25797048, 27084428, 15047842, 23151908, 24611062, 24282571, 26418879, 26919102, 17684018, 25686830, 16585200, 26208478, 18832563, 27697523, 26134617, 19568785, 21750652, 20920357, 21049033, 24905095, 18041091, 12370495, 24446434, 22928011, 12208782, 20112989, 19291319, 21996732, 19863783, 25375133, 11752635, 23437141, 21625516, 20026151, 23409093, 12642872, 26388843, 12504922, 15048882, 17179228, 23242584, 27800505, 23705826, 19574994, 16807298, 25168062, 21325624, 21072193, 12060641, 27922982, 17974987, 17156483, 12089369, 18557931, 20863403, 22902327, 19134195, 25418727, 23167739, 25624750, 15047712, 15475446, 24562770, 26053093, 22207758, 12167717, 16182322, 26104298, 17158952, 26974342, 11756242, 23380710, 16169930, 23799035, 26378810, 25445049, 12149249, 18586515, 19550420, 17848913, 19602055, 20736160, 26496360, 23402310, 21821012, 16168126, 25122478, 22739265, 24042734, 14568991, 16044149, 17342093, 27027448, 15044083, 17342096, 21871173, 25040157, 27163678, 28035333, 16636147, 26053620, 22131882, 23440515, 26039541, 27091625, 19238332, 27000941, 24944883, 24402647, 15489214, 22532249, 23326514, 21908616, 24094245, 15289499, 23652833, 22155350, 17342203, 11162641, 16306364, 15183529, 21297971, 28099937, 19112161, 16266983, 23928696, 25701004, 28188308, 21887250, 11777539, 19525380, 25603341, 20537156, 22685542, 27487130, 16546978, 26379195, 23623968, 23554999, 10986289, 18409144, 26359868, 15289328, 20428959, 21086135, 17724478, 19039330, 24107614, 27196502, 12835332, 24179501, 24280348, 21402788, 18397976, 20470857, 27901111, 27220846, 22107784, 23892273, 18725974, 27762303, 14981538, 22322917, 23152054, 11389054, 24052256, 19997600, 25385184, 25373319, 21309701, 16543232, 25935150, 25797258, 24804226, 24384983, 26345416, 21461637, 20944421, 21425139, 20952497, 12838322, 24324490, 23802099, 23094058, 21259330, 14679308, 22039466, 24615340, 24454800, 16942862, 16100524, 18958173, 25456951, 27302366, 25245332, 19055754, 22771387, 17615157, 21215240, 12171932, 26078792, 11731414, 21212404, 15805282, 26242183, 19616927, 10579725, 23091617, 16759849, 23979601, 10825497, 15919790, 27239959, 21840189, 23119004, 21559502, 24571487, 27074558, 17883592, 17875968, 17372251, 19686698, 26717963, 15157674, 19079341, 21364639, 12438236, 19505958, 24428908, 17407381, 23940704, 14707121, 25277204, 17971124, 24070020, 20585660, 16330671, 26260992, 19183465, 25933112, 23007634, 20054340, 22245935, 20167420, 28008153, 24040255, 25978653, 25375272, 17409645, 18332867, 11027222, 12682057, 20042122, 23142241, 20364113, 20936097, 27192118, 12876303, 21672148, 21660042, 20375905, 27506466, 23086641, 25962159, 19171933, 21904110, 22421143, 11029403, 23552696, 20400975, 26992219, 12654898, 11711890, 25807261, 27138223, 15026145, 17611133, 28003335, 27634878, 19796390, 20418907, 22590634, 23420345, 21059203, 25352995, 21128248, 22110663, 22952709, 22257771, 18838385, 21750219, 25026292, 24024143, 23263555, 14767876, 20106927, 21097843, 20371728, 12115344, 27494022, 23840605, 19166270, 19661305, 25365322, 23077590, 19331694, 26937641, 18370992, 25766325, 24150605, 16636132, 24260371, 20501647, 23922774, 16299382, 23443316, 20334367, 23824914, 26646023, 23396361, 22204954, 15347471, 22911700, 20081374, 22194965, 16886599, 20927395, 25974307, 25248616, 15339992, 20978158, 20205745, 17339610, 18068336, 26877709, 23408974, 17178855, 26839558, 21081844, 25603236, 24729100, 12176337, 23995785, 15657900, 25085593, 23707764, 27829222, 18443205, 26304753, 24523904, 25504433, 20130777, 24349321, 21472003, 11960368, 20361045, 26485768, 24676635, 24916379, 25409876, 21837363, 23573286, 25678401, 26993775, 11323521, 27187380, 26125228, 17196933, 26483070, 12124352, 23590596, 23259744, 19638206, 11825911, 27654866, 26883103, 27494895, 24613353, 23319332, 16224792, 27026523, 11042204, 17935137, 23764845, 23190608, 17646396, 27223432, 21296133, 25311616, 25793983, 11062251, 10415336, 10716737, 26313911, 11208609, 19762915, 16505097, 22253197, 27486771, 27176505, 19740993, 26746999, 22422409, 22879882, 22809628, 25280966, 17721885, 26959890, 22745786, 15574783, 15545271, 17400190, 25767601, 17941081, 27811362, 23977025, 27121065, 20049209, 26415504, 23383195, 27137757, 23050041, 23803188, 21496273, 15537647, 20152809, 27031247, 28035062, 26868304, 26115086, 28002802, 27481935, 19834495, 17098228, 17106060, 24612393, 19255520, 17300726, 18439899, 20950443, 18054038, 25228590, 20517722, 21402741, 25738366, 23343403, 19402821, 23912456, 12446602, 24244612, 27328758, 20054000, 25311506, 22139837, 21329883, 27765055, 22487004, 16183860, 21505451, 18577685, 19293927, 23566222, 23928304, 25760026, 20716939, 23676467, 10477751, 19574502, 26246284, 27014421, 22709426, 21078168, 15456405, 17289898, 27494849, 24073922, 28247844, 20169162, 19074832, 17556533, 19134226, 19574087, 22363598, 17977950, 19211028, 20362557, 25486524, 20090934, 14769856, 27982928, 12556562, 26104664, 20860815, 25295093, 20451318, 21193562, 27048245, 18363844, 24157493, 27487122, 21080918, 25963408, 24977346, 19693287, 21898122, 12686550, 24058557, 12839924, 16166302, 26506516, 9722592, 24649407, 26126266, 24358196, 25997832, 19779850, 27294151, 19144640, 11162573, 24377058, 15084475, 18487214, 24280901, 25111376, 18725386, 16397250, 19465931, 22347457, 16397254, 17468516, 21602804, 17983605, 24232099, 25365190, 21626435, 12493740, 20183800, 23165443, 20011604, 18498165, 17652589, 23668972, 16987514, 22337773, 10908564, 20975834, 22799881, 25063029, 23419269, 21818627, 22060274, 28208754, 19633130, 18931700, 12939297, 24413065, 19472218, 23732709, 11731021, 18854827, 24091816, 26317515, 17967879, 17594810, 20494139, 23671619, 14727512, 24625973, 24448243, 16497409, 20489726, 23091605, 15364915, 12034358, 27622707, 26174628, 16940288, 26061531, 23045700, 27397543, 16341040, 23303682, 27200496, 25888955, 23570421, 21445305, 25784113, 28179017, 24992302, 19109987, 16684529, 20555032, 25098276, 12637511, 21908613, 22781553, 26528819, 22280833, 19676105, 26025205, 22902833, 21724622, 25212826, 20068168, 15010337, 25933104, 19388003, 12815460, 26880110, 27015152, 20804212, 16132952, 23900743, 26317998, 18261725, 19808981, 27894090, 23680186, 27866093, 23049696, 25915946, 24705275, 20216949, 23618343, 26130968, 18508192, 21310961, 17721914, 18812223, 26199094, 17234785, 21157483, 28209617, 25071759, 24654606, 18199958, 25538040, 25898313, 20299475, 26023089, 25400915, 18838554, 28075016, 11162904, 22570727, 25596747, 25966642, 22975683, 25691053, 12351701, 19492080, 25544763, 19720798, 26859575, 24941119, 26121643, 18197291, 15920762, 21300751, 22473959, 22690138, 24462769, 16275989, 18691227, 9736715, 10226029, 25313141, 27784766, 23803661, 23902739, 22458600, 24336406, 22614157, 21804606, 22789858, 25432075, 19262472, 21984893, 22029423, 20014066, 21722370, 26948085, 12164932, 23274898, 26958085, 26613407, 26515499, 19175524, 25110549, 25851605, 11007949, 21350947, 23208610, 21447180, 22142888, 23623869, 28096970, 26909320, 27379204, 23517112, 27627761, 19956873, 27974696, 21592956, 24521094, 23291718, 26741489, 12657951, 16785234, 27211495, 25999352, 10926925, 20352231, 25792811, 26557705, 11311245, 25288334, 18305032, 27285760, 15138635, 27919290, 25179402, 27076174, 26497580, 17640984, 24374242, 16009706, 22705730, 24098385, 16761106, 22293289, 22084251, 26043921, 24979463, 23468988, 18204829, 14572154, 26073086, 21423211, 22912850, 16475687, 23990921, 18821707, 27636107, 20844023, 28231291, 25915159, 26988603, 24900620, 20039275, 22289259, 21284537, 20333467, 23272152, 19724902, 26121251, 26111057, 17646428, 22824823, 25551293, 11278269, 23867201, 15733940, 24416349, 26198194, 22460505, 24979261, 10597260, 20163786, 22025163, 25105067, 23693014, 26582390, 23255002, 25316332, 16567092, 22509246, 27012197, 24743054, 20685965, 22248929, 28231796, 22235305, 16940331, 26046303, 16440211, 15870831, 15546863, 16172130, 24247980, 16221682, 25109354, 11577096, 27323778, 27551486, 15738003, 25196260, 18426604, 12649200, 26751215, 21436253, 24525337, 27659528, 21965657, 22253983, 15372623, 17259384, 24338765, 15755769, 20412566, 19786063, 27988337, 20186153, 26323834, 24023938, 21040800, 25658447, 25096023, 26500282, 26243309, 23440594, 16168102, 20527022, 17096325, 21464307, 20980511, 16962287, 22530768, 23389114, 24039912, 26110874, 24523415, 22262182, 11896604, 18356579, 22839755, 23415012, 19216748, 21666717, 10471319, 21144036, 21253589, 27769069, 18670617, 22911754, 22830422, 19946332, 28008155, 20663232, 20383279, 16531397, 26246598, 23951353, 25273559, 23176396, 25969668, 19326566, 16987028, 25640278, 27966531, 24996256, 22956257, 20530982, 26974310, 16785763, 22739986, 23935944, 23237355, 26535060, 26635480, 27346647, 25035961, 20167101, 25965345, 25744065, 26333304, 27054717, 21192818, 26557719, 27166156, 23226698, 23799852, 10637513, 24628780, 15327518, 27387559, 25623055, 24605828, 17309805, 27533087, 26821070, 25564612, 25719244, 21514425, 19158829, 23989949, 27323822, 26959555, 25569743, 27863406, 15913452, 27602766, 18721797, 22211100, 27294206, 26356562, 26657992, 22384145, 21600017, 23383347, 17634416, 20804500, 18665222, 24188406, 22905202, 28213783, 19448664, 11003625, 22927331, 19320971, 28249041, 27694970, 26497682, 26408176, 18931031, 18818526, 21625639, 24627641, 15837416, 21437771, 21952497, 24955034, 24356956, 21698202, 19035551, 25926716, 20628892, 25894595, 20150288, 19055752, 25574799, 17041888, 22510297, 26994872, 25910265, 12869408, 20454577, 26440416, 27656263, 26821351, 25530715, 25257523, 28151479, 20540782, 12644590, 22259221, 21538438, 24365180, 27390173, 19166928, 20597130, 19564927, 16549426, 11702042, 25749517, 25749514, 25490861, 23243000, 25961827, 26436418, 19517019, 15150572, 18256540, 26573229, 26840401, 24113173, 26912358, 14660586, 26402673, 22900072, 17003457, 28232663, 25940338, 23426781, 25965823, 20045673, 26023079, 17684102, 17062729, 26931119, 27601656, 15792609, 27304189, 22407228, 27793011, 12373610, 24098375, 26784926, 25412313, 24156551, 24053190, 21600875, 25674039, 23427269, 23776620, 22629392, 23933705, 24675668, 24669186, 26657290, 22184107, 27004402, 25654224, 24273605, 27004407, 27004406, 21655183, 20520724, 22016349, 22563417, 27180807, 19422047, 27020593, 11893783, 26222278, 25639875, 23209838, 22569334, 19164772, 24933731, 27487157, 26988652, 26716408, 25649767, 23147412, 14761976, 23142521, 22880048, 20679434, 23940660, 18262492, 23650507, 25136826, 17548608, 21644050, 26682007, 27412013, 26801096, 10874027, 18480058, 17013611, 20836557, 11313365, 20217555, 23285096, 25495560, 24161930, 25673820, 23681745, 27768588, 16962653, 25329617, 25296981, 27680387, 21874045, 24316235, 26708293, 26762111, 11358816, 23155381, 23580233, 24662831, 27119232, 27274989, 19701246, 22957045, 25528216, 27659207, 21471536, 23644504, 24023012, 26014912, 21763421, 15870708, 23762398, 21415306, 27549161, 26832662, 21956113, 23785417, 17961125, 22382990, 9632753, 17308356, 19644030, 17923279, 23420486, 21131356, 19284309, 25663935, 18678787, 23748344, 25869208, 18391071, 24561239, 26903300, 26714756, 11289110, 21281201, 26879868, 28061880, 27053161, 21106850, 24392034, 26600389, 22185378, 21278786, 27391443, 21333374, 20333297, 17622239, 27391151, 17960559, 23946798, 26998277, 21871446, 21767636, 20817061, 22415553, 19602587, 26580610, 15678105, 10722653, 23684622, 27611696, 12210737, 27152946, 23072587, 17545609, 19114562, 10226025, 24379655, 23682967, 22550181, 9857186, 18059161, 14990993, 25376904, 25388642, 27489350, 15050414, 26244501, 22733130, 17334390, 24352480, 24201812, 24169049, 21741919, 20051961, 24670043, 19133120, 18349842, 20421190, 24984001, 19176384, 10491755, 12466352, 26402468, 27449083, 27494886, 15319269, 27290989, 20126311, 23824064, 15998799, 28072855, 26761017, 23011139, 16722146, 22116303, 27430155, 26756739, 24797432, 27484721, 26942872, 23469007, 23082158, 28022022, 25823655, 27047993, 28056899, 24387036, 27499633, 24868319, 24810113, 23182460, 23673367, 19011679, 26891914, 24036604, 25793261, 11359783, 25687876, 24551245, 22657251, 26345302, 25531880, 17237292, 26565813, 24618420, 26151347, 10994851, 23844554, 26235620, 24372645, 26354606, 24581231, 22391563, 15718470, 27776559, 26657292, 16288304, 23632475, 19996208, 26848618, 20224651, 21283818, 28176801, 26700664, 27809307, 23874694, 25980493, 26252009, 23071583, 25243120, 25370471, 20941790, 27992958, 15505622, 24467442, 19302240, 21867682, 12529330, 18477468, 26716652, 23311938
Y474 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 12149249
S475 Phosphorylation PhosphoSitePlus   RLIMS-P 26317547
S477 Phosphorylation PhosphoSitePlus   RLIMS-P 24795023, 24933731, 27390173
T479 Phosphorylation PhosphoSitePlus   RLIMS-P 24795023, 24933731
Site PTM Type PTM Enzyme Score Source PMID
T72 Phosphorylation PRO 16549426
S122 Phosphorylation HPRD 19651622, 20166139, 18669648, ...18452278
S124 Phosphorylation HPRD 20166139, 12149249, 18669648, ...18452278
S126 Phosphorylation HPRD 18669648, 17081983, 18452278
S129 Phosphorylation HPRD 20166139, 12149249, 18669648, ...18452278
S246 Phosphorylation PRO 16549426
T308 Phosphorylation Q8N5S9 (CAMKK1) , Q15118 (PDK1) , PR:000010165 (MAPKAPK2) , O15530 (PDPK1) HPRD   PRO 10226025, 11278835, 14500673, ...11445557, 16603397, 9368760, 16253990, 12149249, 16549426, 10833263, 8978681
Y315 Phosphorylation P12931 (SRC) HPRD 11445557
Y326 Phosphorylation P12931 (SRC) HPRD 11445557
T450 Phosphorylation HPRD 12149249
S473 Phosphorylation PR:000010165 (MAPKAPK2) , Q13418 (ILK) , O15530 (PDPK1) , Q15118 (PDK1) , Q8TAI7 (RHEBL1) HPRD   PRO 11723139, 10226025, 11278835, ...14500673, 12176337, 16260598, 11445557, 16603397, 16549426, 9736715, 16098514, 16253990, 12149249, 16917505, 8978681
Y474 Phosphorylation HPRD 12149249


P31749 (AKT1) as PTM Enzyme



Substrate Site Score Source PMID
O14492 (SH2B2) S598 neXtProt 16141217
O14746 (TERT) S227 HPRD   neXtProt   PhosphoSitePlus   Signor 10224060
O14746 (TERT) S824 neXtProt   PhosphoSitePlus   Signor 10224060
O14757-1 (CHEK1) S280 HPRD   neXtProt   PhosphoSitePlus   Signor 18691976, 12062056, 19664995, ...18669648, 20068231, 15107605
O15111 (CHUK) T23 HPRD   neXtProt   PhosphoSitePlus   Signor 19609947, 10485710, 18515365
O15151-1 (MDM4) S342 HPRD 16163388, 16511560
O15151 (MDM4) S367 neXtProt   PhosphoSitePlus   Signor 18356162
O15360-1 (FANCA) S1149 HPRD   neXtProt   PhosphoSitePlus 11855836
O15519 (CFLAR) S273 PhosphoSitePlus   Signor 19339247
O43464 (HTRA2) S212 neXtProt   PhosphoSitePlus   Signor 17311912
O43521 (BCL2L11) S87 neXtProt   PhosphoSitePlus   Signor 16282323
O43524-1 (FOXO3) T32 HPRD   neXtProt   PhosphoSitePlus 10910908, 10102273, 10995739, ...11154281
O43524 (FOXO3) S253 HPRD   neXtProt   PhosphoSitePlus 10910908, 10102273, 10995739, ...20068231, 11154281
O60285 (NUAK1) S600 neXtProt   PhosphoSitePlus   Signor 15060171, 12409306
O60331 (PIP5K1C) S555 PhosphoSitePlus 26149501
O60343 (TBC1D4) S318 PhosphoSitePlus 26465605
O60343 (TBC1D4) S588 PhosphoSitePlus 26465605
O60343 (TBC1D4) T642 neXtProt   PhosphoSitePlus   Signor 11994271, 26465605, 16880201
O60825 (PFKFB2) S466 HPRD   neXtProt   PhosphoSitePlus   Signor 19413330, 18767875, 18669648, ...19651622, 10521487, 12853467, 20068231, 17924679
O60825 (PFKFB2) S483 HPRD   neXtProt   PhosphoSitePlus   Signor 12853467, 19651622, 18669648, ...23457334, 20068231
O75376 (NCOR1) S1450 PhosphoSitePlus   Signor 23940660
O95999 (BCL10) S218 neXtProt   PhosphoSitePlus 16280327
O95999 (BCL10) S231 neXtProt   PhosphoSitePlus 16280327
P00533 (EGFR) S229 PhosphoSitePlus 21487020
P02545 (LMNA) S301 neXtProt   PhosphoSitePlus 23430973, 18808171
P02545 (LMNA) S404 neXtProt   PhosphoSitePlus 23430973, 18808171
P03372 (ESR1) S104 Signor 11108261
P03372 (ESR1) S106 Signor 11108261
P03372 (ESR1) S118 Signor 11108261
P03372-1 (ESR1) S167 HPRD   neXtProt   PhosphoSitePlus   Signor 11108261, 11139588, 16113102
P03372 (ESR1) S305 neXtProt   PhosphoSitePlus 20101208
P04049-1 (RAF1) S259 HPRD   neXtProt 18691976, 11971957, 20230923, ...12087097, 18767875, 18669648, 11997508, 10576742, 20068231
P04150 (NR3C1) S134 PhosphoSitePlus   Signor 24291004
P04792 (HSPB1) S82 PhosphoSitePlus   Signor 19593530, 12740362
P05106 (ITGB3) T767 neXtProt 10896934
P05106 (ITGB3) T779 HPRD   PhosphoSitePlus   Signor 18578522, 10896934
P05455 (SSB) T302 neXtProt 18836485
P07550 (ADRB2) S345 Signor 11809767
P07550 (ADRB2) S346 neXtProt   PhosphoSitePlus   Signor 11809767
P08047 (SP1) S42 PhosphoSitePlus 22718198
P08047 (SP1) T679 PhosphoSitePlus 22718198
P08047 (SP1) S698 PhosphoSitePlus 22718198
P08670 (VIM) S39 neXtProt   PhosphoSitePlus   Signor 20856200
P09601 (HMOX1) S188 HPRD   neXtProt   PhosphoSitePlus   Signor 15581622
P09651 (HNRNPA1) S199 neXtProt   PhosphoSitePlus   Signor 18562319
P10275-1 (AR) S208 HPRD 11404460
P10275-1 (AR) S215 HPRD   PhosphoSitePlus   Signor 14555644, 17470458, 11156376, ...11404460
P10275-2 (AR) S260 HPRD 11404460
P10275 (AR) S792 HPRD   PhosphoSitePlus 14555644, 11404460, 11156376, ...17470458
P10276 (RARA) S96 neXtProt   PhosphoSitePlus   Signor 16417524
P12755 (SKI) T458 neXtProt   PhosphoSitePlus   Signor 19875456
P14598 (NCF1) S304 neXtProt   PhosphoSitePlus   Signor 12734380, 10559253
P14598 (NCF1) S328 neXtProt   PhosphoSitePlus   Signor 12734380, 10559253
P15056 (BRAF) S365 HPRD   neXtProt   PhosphoSitePlus   Signor 10869359, 20230923, 20058876, ...18452278, 19651622, 18669648, 11410590, 20068231
P15056 (BRAF) S429 HPRD   neXtProt   PhosphoSitePlus   Signor 10869359
P15976 (GATA1) S310 HPRD   neXtProt   PhosphoSitePlus   Signor 8206977, 16107690, 26680303
P16220 (CREB1) S133 HPRD   neXtProt   Signor 9829964
P17302 (GJA1) S369 neXtProt 18163231
P17302 (GJA1) S373 neXtProt 18163231
P17542 (TAL1) T90 neXtProt   PhosphoSitePlus 19406989, 15930267
P18031 (PTPN1) S50 HPRD   neXtProt   PhosphoSitePlus 18691976, 11579209
P19174 (PLCG1) S1248 PhosphoSitePlus 16525023
P19634 (SLC9A1) S648 neXtProt   PhosphoSitePlus 18757828, 20026127
P19634 (SLC9A1) S703 neXtProt   PhosphoSitePlus 18757828, 20026127
P19634 (SLC9A1) S796 neXtProt   PhosphoSitePlus 18757828, 20026127
P21333 (FLNA) S2152 PhosphoSitePlus 25944616
P21453 (S1PR1) T236 HPRD   neXtProt   PhosphoSitePlus   Signor 11583630
P22736 (NR4A1) S351 HPRD   neXtProt   PhosphoSitePlus   Signor 11274386, 18669648, 16434970
P23396 (RPS3) T70 neXtProt   PhosphoSitePlus 20605787
P23588 (EIF4B) S422 neXtProt   Signor 18836482
P23769-1 (GATA2) S401 HPRD   neXtProt   PhosphoSitePlus   Signor 15837948
P24941 (CDK2) T39 neXtProt   PhosphoSitePlus   Signor 18354084
P26358 (DNMT1) S143 neXtProt   PhosphoSitePlus   Signor 21151116
P26678 (PLN) S16 neXtProt 18838385
P29317 (EPHA2) S897 PhosphoSitePlus 19573808
P29401 (TKT) T382 PhosphoSitePlus 24981175
P29401 (TKT) S387 PhosphoSitePlus 24981175
P29474 (NOS3) S615 neXtProt   PhosphoSitePlus   Signor 12171920, 24379783
P29474 (NOS3) S1177 HPRD   neXtProt   PhosphoSitePlus   Signor 10376603, 12171920, 12511559, ...11729179, 11696579, 18622039, 20166139, 12446767
P30291 (WEE1) S642 PhosphoSitePlus 15964826
P31749 (AKT1) T72 neXtProt   PhosphoSitePlus 16549426
P31749 (AKT1) S246 neXtProt   PhosphoSitePlus 16549426
P33778 (HIST1H2BB) S37 neXtProt 8985174
P35222 (CTNNB1) S552 neXtProt   PhosphoSitePlus   Signor 17287208, 12063252
P35226 (BMI1) S316 PhosphoSitePlus 23092893
P35232 (PHB) T258 PhosphoSitePlus 25719244, 22410782
P35240 (NF2) S10 PhosphoSitePlus 21750658
P35240 (NF2) T230 PhosphoSitePlus 24166499
P35240 (NF2) S315 PhosphoSitePlus 24166499
P35568 (IRS1) S629 neXtProt   PhosphoSitePlus 17640984
P38398-8 (BRCA1) T462 HPRD 10542266
P38398 (BRCA1) T509 HPRD   neXtProt   PhosphoSitePlus   Signor 10542266, 17428466, 20085797
P38398 (BRCA1) S694 neXtProt   PhosphoSitePlus   Signor 20085797
P38936 (CDKN1A) T145 HPRD   neXtProt   PhosphoSitePlus   Signor 11231573, 16982699, 15173090, ...11756412, 11463845, 17855660
P38936 (CDKN1A) S146 HPRD   neXtProt   PhosphoSitePlus   Signor 11756412, 16982699, 17855660
P41219 (PRPH) S59 neXtProt 17569669
P41279-1 (MAP3K8) S400 HPRD   PhosphoSitePlus   Signor 12138205
P41279-1 (MAP3K8) S413 HPRD   Signor 12138205
P42345 (MTOR) T2446 HPRD   neXtProt   PhosphoSitePlus   Signor 14970221, 10910062
P42345 (MTOR) S2448 HPRD   neXtProt   PhosphoSitePlus   Signor 18691976, 19664994, 10910062, ...15208671, 10567225
P42858 (HTT) S419 neXtProt   PhosphoSitePlus   Signor 16452687, 14725621, 12062094, ...15843398
P45985-1 (MAP2K4) S80 HPRD   neXtProt   PhosphoSitePlus   Signor 11707464, 15911620
P46527 (CDKN1B) S10 neXtProt   PhosphoSitePlus   Signor 16780593, 12042314, 14504289
P46527 (CDKN1B) T157 HPRD   neXtProt   PhosphoSitePlus   Signor 18710949, 12244301, 18570873, ...12244302, 12244303, 15579463, 15743786
P46527 (CDKN1B) T187 neXtProt 14504289
P46527 (CDKN1B) T198 neXtProt   PhosphoSitePlus   Signor 18710949, 15280662, 15743786, ...12042314, 14504289
P46937 (YAP1) S127 neXtProt   PhosphoSitePlus   Signor 21945154, 12535517
P47870 (GABRB2) S472 neXtProt 12818177
P48431 (SOX2) T118 neXtProt 20945330
P48730 (CSNK1D) S370 neXtProt 17594292
P49760 (CLK2) S34 neXtProt   PhosphoSitePlus   Signor 20682768
P49760 (CLK2) T127 neXtProt   PhosphoSitePlus   Signor 20682768
P49815 (TSC2) S939 HPRD   neXtProt   PhosphoSitePlus 16636147, 12438239, 12150915, ...15342917, 18707149, 20169078
P49815 (TSC2) S981 PhosphoSitePlus 16636147
P49815-1 (TSC2) T1462 HPRD   neXtProt   PhosphoSitePlus 12150915, 15342917, 19664994
P49840 (GSK3A) S21 HPRD   neXtProt   PhosphoSitePlus   Signor 11884598, 19413330, 12054501, ...18691976, 11749387, 11563975, 11340086, 11035810, 11577096
P49841 (GSK3B) S9 HPRD   neXtProt   PhosphoSitePlus   Signor 9373175, 18691976, 8985174, ...12054501, 11563975, 15457186, 11340086, 23552696, 18669648, 11577096, 12900420
P49918 (CDKN1C) S282 PhosphoSitePlus   Signor 23421998
P49918 (CDKN1C) T310 PhosphoSitePlus   Signor 23421998
P51617-4 (IRAK1) T66 HPRD 11976320
P51617 (IRAK1) T100 HPRD   PhosphoSitePlus   Signor 11976320
P53365 (ARFIP2) S260 neXtProt   PhosphoSitePlus   Signor 15809304
P53804 (TTC3) S378 neXtProt   PhosphoSitePlus   Signor 20059950
P54253 (ATXN1) S775 HPRD   neXtProt   PhosphoSitePlus   Signor 12741986, 12757707, 17540008
P54274 (TERF1) T273 neXtProt   PhosphoSitePlus 19160102
P54578 (USP14) S432 PhosphoSitePlus 26523394
P54646 (PRKAA2) S491 neXtProt 16340011
P55072 (VCP) S352 neXtProt   PhosphoSitePlus   Signor 16551632, 16027165
P55072 (VCP) S746 neXtProt   PhosphoSitePlus   Signor 16551632, 16027165
P55072 (VCP) S748 neXtProt   PhosphoSitePlus   Signor 16551632, 16027165
P55211-1 (CASP9) S183 HPRD 9812896
P55211 (CASP9) S196 HPRD   neXtProt   PhosphoSitePlus   Signor 9812896, 15004527, 10529400
P55316 (FOXG1) T279 neXtProt   PhosphoSitePlus 17435750, 21228151
P56270 (MAZ) T385 PhosphoSitePlus 26902421
P60484-1 (PTEN) S380 HPRD 12077256, 10866658
P60484-1 (PTEN) S385 HPRD 12077256, 12297295
P62136 (PPP1CA) T320 neXtProt   PhosphoSitePlus   Signor 14633703, 12202491, 17202132
P63000 (RAC1) S71 HPRD   neXtProt   PhosphoSitePlus   Signor 18669648, 10617634
P63104-1 (YWHAZ) S58 HPRD   neXtProt   PhosphoSitePlus   Signor 11956222
P63104-1 (YWHAZ) S184 HPRD 11956222
P67809 (YBX1) S102 HPRD   neXtProt   PhosphoSitePlus   Signor 16354698, 19651622, 19036157, ...15806160, 19664994
P68400 (CSNK2A1) T13 PhosphoSitePlus 24297901
P78362 (SRPK2) T492 neXtProt   PhosphoSitePlus   Signor 19592491
P78371 (CCT2) S260 neXtProt   PhosphoSitePlus   Signor 19332537
P84022 (SMAD3) T179 PhosphoSitePlus 26297431
P84243 (H3F3B) S11 neXtProt 12529330
P98170 (XIAP) S87 HPRD   neXtProt   PhosphoSitePlus   Signor 17537996, 14645242
P98177 (FOXO4) T32 HPRD   neXtProt   PhosphoSitePlus   Signor 11313479, 19664994, 16272144
P98177 (FOXO4) S197 HPRD   neXtProt   PhosphoSitePlus   Signor 11313479, 10217147, 16272144
P98177 (FOXO4) S262 HPRD   neXtProt   PhosphoSitePlus   Signor 11313479, 10217147, 16272144
P98177-1 (FOXO4) T451 HPRD 11689711
P98177-1 (FOXO4) T455 HPRD 11689711
Q00987 (MDM2) S166 HPRD   neXtProt   PhosphoSitePlus   Signor 15169778, 11715018, 11850850, ...11960368, 15527798, 11504915
Q00987-11 (MDM2) S172 HPRD 11504915, 19664995
Q00987 (MDM2) S186 neXtProt   PhosphoSitePlus   Signor 11923280, 11504915, 11715018
Q00987 (MDM2) S188 neXtProt   PhosphoSitePlus   Signor 15169778, 15527798
Q00987-11 (MDM2) S192 HPRD 11504915
Q01860 (POU5F1) T235 Signor 23041284
Q04912 (MST1R) S1394 neXtProt   PhosphoSitePlus   Signor 14505491, 12919677
Q05195 (MXD1) S145 neXtProt   PhosphoSitePlus   Signor 18451027, 19526459
Q05397 (PTK2) S695 neXtProt   PhosphoSitePlus 23264741
Q05397 (PTK2) T700 neXtProt   PhosphoSitePlus 23264741
Q06187 (BTK) S51 PhosphoSitePlus 23754751
Q06187 (BTK) T495 PhosphoSitePlus 23754751
Q07352 (ZFP36L1) S92 neXtProt   PhosphoSitePlus   Signor 15538381
Q07352 (ZFP36L1) S203 neXtProt   PhosphoSitePlus 17030608
Q07812 (BAX) S184 Signor 14766748
Q09472 (EP300) S1834 HPRD   neXtProt   PhosphoSitePlus   Signor 16024795, 11116148, 16926151, ...23275565
Q12778 (FOXO1) T24 HPRD   neXtProt   PhosphoSitePlus 11237865, 10358014, 11311120, ...10358075
Q12778 (FOXO1) S256 HPRD   neXtProt   PhosphoSitePlus 11237865, 10358014, 11311120, ...15668399, 16076959, 10358075
Q12778 (FOXO1) S319 HPRD   neXtProt   PhosphoSitePlus   Signor 11237865, 10358014, 11311120, ...10358075
Q12906 (ILF3) S647 neXtProt   PhosphoSitePlus   Signor 18097023, 20870937
Q13009 (TIAM1) S231 PhosphoSitePlus 25746002
Q13043 (STK4) T120 neXtProt   PhosphoSitePlus   Signor 19940129
Q13043 (STK4) T387 neXtProt   Signor 17726016, 23431053
Q13107 (USP4) S445 PhosphoSitePlus 22706160
Q13131 (PRKAA1) S496 neXtProt 16340011
Q13153 (PAK1) S21 neXtProt 14585966
Q13188 (STK3) T117 neXtProt   PhosphoSitePlus   Signor 20231902, 20086174
Q13188 (STK3) T384 neXtProt   PhosphoSitePlus   Signor 20086174
Q13322 (GRB10) S428 neXtProt 15722337
Q13370-1 (PDE3B) S295 HPRD   neXtProt   Signor 10454575
Q13370-1 (PDE3B) S318 HPRD 10454575
Q13370-1 (PDE3B) S442 HPRD 18669648, 10454575
Q13541 (EIF4EBP1) T37 HPRD 11777913, 19413330, 19664995, ...19651622, 18669648, 20068231
Q13541 (EIF4EBP1) T46 HPRD 11777913, 19413330, 19664995, ...19651622, 18669648, 20068231
Q13541 (EIF4EBP1) S65 HPRD 11777913, 17287340, 18767875, ...19664995, 19651622, 18669648, 20068231
Q13950 (RUNX2) S28 PhosphoSitePlus 23389849
Q13950 (RUNX2) S196 PhosphoSitePlus 23389849
Q13950 (RUNX2) T198 PhosphoSitePlus 23389849
Q13950 (RUNX2) T200 PhosphoSitePlus 23389849
Q14315 (FLNC) S2233 neXtProt   PhosphoSitePlus 15461588
Q14457 (BECN1) S295 PhosphoSitePlus 23112296
Q14643 (ITPR1) S2690 neXtProt 16332683
Q14957 (GRIN2C) S1081 neXtProt 19477150
Q15027 (ACAP1) S554 neXtProt   PhosphoSitePlus   Signor 16256741
Q15121 (PEA15) S116 HPRD   neXtProt   PhosphoSitePlus   Signor 19413330, 18578522, 17287340, ...18212344, 18767875, 19664995, 18452278, 19651622, 18669648, 12808093, 20166139, 9721757, 20068231
Q15365 (PCBP1) S43 neXtProt 20154680
Q15672 (TWIST1) S42 neXtProt   PhosphoSitePlus   Signor 20400976
Q15672 (TWIST1) S123 neXtProt   PhosphoSitePlus 20400976
Q15910-2 (EZH2) S21 HPRD   neXtProt   PhosphoSitePlus   Signor 16224021
Q15942 (ZYX) S142 neXtProt   PhosphoSitePlus   Signor 17572661
Q16584 (MAP3K11) S674 HPRD   neXtProt   PhosphoSitePlus   Signor 26152725, 12458207
Q16875 (PFKFB3) S461 neXtProt   PhosphoSitePlus   Signor 15896703
Q3V6T2-2 (CCDC88A) S1417 HPRD   neXtProt   PhosphoSitePlus   Signor 16139227, 20068231
Q53EL6 (PDCD4) S67 neXtProt   PhosphoSitePlus   Signor 17053147, 18296647, 16357133
Q53EL6 (PDCD4) S457 neXtProt   PhosphoSitePlus   Signor 16357133
Q6R327 (RICTOR) T1135 PhosphoSitePlus 20832730
Q7L5N1 (COPS6) S60 PhosphoSitePlus   Signor 23095642
Q7Z589 (EMSY) S209 PhosphoSitePlus 22315412
Q7Z5H3 (ARHGAP22) S16 neXtProt   PhosphoSitePlus 21969604
Q7Z6J0 (SH3RF1) S304 neXtProt   PhosphoSitePlus   Signor 17535800
Q86TI0 (TBC1D1) S235 neXtProt 17995453
Q86TI0 (TBC1D1) T596 neXtProt   PhosphoSitePlus 17995453
Q86V81 (ALYREF) S34 neXtProt   PhosphoSitePlus 18562279
Q86V81 (ALYREF) T219 neXtProt   PhosphoSitePlus   Signor 18562279
Q86VP3 (PACS2) S437 PhosphoSitePlus 23852728
Q86YN6 (PPARGC1B) S570 neXtProt 17554339
Q8IYJ3 (SYTL1) S241 PhosphoSitePlus 15998322
Q8N6T7 (SIRT6) S338 PhosphoSitePlus 25074979
Q8NCD3 (HJURP) S486 neXtProt   PhosphoSitePlus 17256767
Q8WX93 (PALLD) S1118 neXtProt   PhosphoSitePlus   Signor 20471940
Q8WYL5 (SSH1) T826 PhosphoSitePlus 25100728
Q92547 (TOPBP1) S1159 neXtProt   PhosphoSitePlus 24081328, 19477925, 17006541
Q92793 (CREBBP) T1871 PhosphoSitePlus 23434580
Q92794 (KAT6A) T369 PhosphoSitePlus 23431171
Q92879 (CELF1) S28 neXtProt   PhosphoSitePlus 18570922
Q92934 (BAD) S75 HPRD   neXtProt   Signor 12897128, 10880354, 9381178, ...10521512, 10837486
Q92934 (BAD) S99 HPRD   neXtProt   PhosphoSitePlus   Signor 21444773, 19664994, 9346240, ...18669648, 19667065, 9651683, 11020382, 10558990, 9381178
Q92934 (BAD) S118 HPRD   Signor 10949026, 9346240, 18669648, ...18707149, 20166139, 10837486
Q92945 (KHSRP) S193 PhosphoSitePlus   Signor 17177604
Q96B36 (AKT1S1) T246 neXtProt   PhosphoSitePlus   Signor 12524439, 17277771
Q96F86 (EDC3) S161 PhosphoSitePlus 20051463
Q96HP0 (DOCK6) S1194 PhosphoSitePlus 23462102
Q96QB1-1 (DLC1) S327 HPRD 16338927
Q96QB1-1 (DLC1) S329 HPRD 16338927
Q96QB1-1 (DLC1) S567 HPRD 16338927
Q96QB1-2 (DLC1) S764 HPRD 16338927
Q96QB1 (DLC1) S766 HPRD   neXtProt 16338927
Q96QB1-2 (DLC1) S1004 HPRD 16338927
Q96S44 (TP53RK) S250 neXtProt   PhosphoSitePlus   Signor 17712528
Q99418 (CYTH2) T276 PhosphoSitePlus 24303080
Q99490-2 (AGAP2) S472 PhosphoSitePlus 21460185
Q99490-2 (AGAP2) S629 neXtProt   PhosphoSitePlus 19176382
Q99490 (AGAP2) S985 Signor 19176382
Q99502 (EYA1) S299 PhosphoSitePlus 24954506
Q99640 (PKMYT1) S83 neXtProt 11802161
Q99683 (MAP3K5) S83 HPRD   neXtProt   PhosphoSitePlus   Signor 11154276, 14500571, 15782121, ...15911620
Q99697 (PITX2) T90 neXtProt 20019746
Q9BPZ7 (MAPKAP1) T86 PhosphoSitePlus 26235620
Q9BRQ0 (PYGO2) S48 PhosphoSitePlus 26170450
Q9BVI0 (PHF20) S265 neXtProt   PhosphoSitePlus 22975685
Q9BVI0 (PHF20) S291 neXtProt   PhosphoSitePlus   Signor 22975685, 22334668
Q9BWT1 (CDCA7) T163 PhosphoSitePlus   Signor 23166294
Q9BZQ8 (FAM129A) S602 neXtProt   PhosphoSitePlus   Signor 22510990
Q9GZV1 (ANKRD2) S99 neXtProt 21737686
Q9H3Z4 (DNAJC5) S10 neXtProt 16243840
Q9H4A3 (WNK1) T60 neXtProt   PhosphoSitePlus   Signor 14611643, 16081417
Q9H4X1-2 (RGCC) S45 neXtProt   PhosphoSitePlus 19162005
Q9H6Z4 (RANBP3) S126 neXtProt   PhosphoSitePlus   Signor 18280241
Q9H9Q4 (NHEJ1) T181 PhosphoSitePlus 25661488
Q9HBH7 (BEX1) S102 neXtProt 16498402
Q9NPC1 (LTB4R2) T355 neXtProt   PhosphoSitePlus   Signor 22044535
Q9NR28 (DIABLO) S67 PhosphoSitePlus 24038446
Q9NWV8 (BABAM1) S29 PhosphoSitePlus 26027929
Q9NZJ5 (EIF2AK3) T802 neXtProt 21954288
Q9P0V3 (SH3BP4) S246 neXtProt 19122209
Q9UBK2 (PPARGC1A) S571 neXtProt   Signor 17554339
Q9UBP6 (METTL1) S27 HPRD   neXtProt   PhosphoSitePlus   Signor 15861136, 3627513
Q9UKV3 (ACIN1) S1180 neXtProt   PhosphoSitePlus 18559500, 16177823
Q9UKV3 (ACIN1) S1329 neXtProt 16177823
Q9UN36 (NDRG2) S332 neXtProt   PhosphoSitePlus 15461589
Q9UN36 (NDRG2) T348 neXtProt   PhosphoSitePlus 15461589
Q9UQB3 (CTNND2) T457 neXtProt 17993462
Q9UQC2 (GAB2) S159 HPRD   neXtProt   PhosphoSitePlus   Signor 11782427
Q9Y261 (FOXA2) T156 PhosphoSitePlus 14500912
Q9Y2I7 (PIKFYVE) S307 neXtProt   PhosphoSitePlus   Signor 15546921
Q9Y2I7 (PIKFYVE) S318 PhosphoSitePlus 23757022
Q9Y2V2 (CARHSP1) S52 neXtProt   PhosphoSitePlus   Signor 15910284
Q9Y3C5 (RNF11) T135 PhosphoSitePlus   Signor 16123141
Q9Y3M2 (CBY1) S20 neXtProt   PhosphoSitePlus 18573912


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046294 (hAKT1/Phos:3) pS473 PRO
PR:000046295 (hAKT1/Phos:4) pT308 PRO
PR:000046296 (hAKT1/Phos:1) pT308,pS473 PRO
PR:000046297 (hAKT1/Phos:5) pY315,pY326 PRO
PR:000027473 (hAKT1/iso:1/Phos:2) pT72,pS246,pT308,pS473 PRO 16549426
PR:000028994 (hAKT1/iso:1/Phos:1) pT308,pS473 PR:000010165 (MAPKAPK2) PRO 8978681


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P29317 (EPHA2) S897 P31749 (AKT1) unknown eFIP 21408136
Phosphorylation P31749 (AKT1) S473 Q3U182 (Crtc2) increased_association eFIP 23300339
Phosphorylation P31749 (AKT1) S473 Q53ET0 (CRTC2) inhibited_association eFIP 22384145
Phosphorylation P31749 (AKT1) T308 Q15118 (PDK1) inhibited_association eFIP 22629392
Phosphorylation P31749 (AKT1) S473 Q15118 (PDK1) increased_association eFIP 27481935
Phosphorylation P31749 (AKT1) T308 O15530 (PDPK1) unknown eFIP 19402821
Phosphorylation P31749 (AKT1) S473 Q3U182 (Crtc2) inhibited_association eFIP 23272152
Phosphorylation P31749 (AKT1) S473 Q68ED7 (Crtc1) inhibited_association eFIP 23303455
Phosphorylation P31749 (AKT1) S473 P45983 (MAPK8) unknown eFIP 22771387
Phosphorylation P31749 (AKT1) S473 P07900 (HSP90AA1) unknown eFIP 25935150
Phosphorylation Q99683 (MAP3K5) S83 P31749 (AKT1) decreased_association eFIP 26912789
Phosphorylation Q9UQF2 (MAPK8IP1) T103 P31749 (AKT1) unknown eFIP 15998799


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000028994 (hAKT1/iso:1/Phos:1) Interaction PR:O14746-1 (hTERT/iso:1) PRO 12586360
PR:000028994 (hAKT1/iso:1/Phos:1) Interaction PR:P41279-1 (hMAP3K8/iso:1) PRO 12138205
PR:000045370 (hCDKN1B/iso:1/UnPhos:2) Interaction PR:P31749 (hAKT1) PRO 12244301