Protein Information

Cytoscape View

UniProt AC / UniProt ID P31323 / KAP3_HUMAN
Protein Name cAMP-dependent protein kinase type II-beta regulatory subunit
Gene Name Name: PRKAR2B
Organism Homo sapiens (Human)

PRO ID PR:P31323
DAG View
PRO Name cAMP-dependent protein kinase type II-beta regulatory subunit (human)
Definition A cAMP-dependent protein kinase type II-beta regulatory subunit that is encoded in the genome of human.
Short Label hPRKAR2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P31323 (PRKAR2B) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T69 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   UniProt 19664994, 8516283, 23186163, ...19664995
S71 Phosphorylation PhosphoSitePlus
S83 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692
S85 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692
S114 Phosphorylation P31323 (PRKAR2B) , P17612 (PRKACA) HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 23186163, 19664995, ...18318008, 19651622, 7479855, 20166139, 19690332, 15822905, 15187164
C116 S-Nitrosylation dbSNO 26338901
Y120 Phosphorylation PhosphoSitePlus
K137 Ubiquitination PhosphoSitePlus
K150 Ubiquitination PhosphoSitePlus
T357 Phosphorylation PhosphoSitePlus
K359 Ubiquitination PhosphoSitePlus
K372 Ubiquitination PhosphoSitePlus
T417 Phosphorylation PhosphoSitePlus

P31323 (PRKAR2B) as PTM Enzyme

Substrate Site Score Source PMID
P31323 (PRKAR2B) S114 HPRD 19651622, 20166139, 7479855, ...19664995
Q14847-1 (LASP1) S99 HPRD 12432067, 20068231
Q14847-1 (LASP1) S146 HPRD 17287340, 18212344, 12571245, ...18077418, 18669648, 20166139, 18088087, 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
C116 Y116 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T417 I417 Biomuta DOID:363 / uterine cancer [ tcga ]