iPTMnet Report P31323 PRKAR2B

Protein Information

Cytoscape View

UniProt AC / UniProt ID	P31323 / KAP3_HUMAN
Protein Name	cAMP-dependent protein kinase type II-beta regulatory subunit
Gene Name	Name: PRKAR2B
Organism	Homo sapiens (Human)

PRO ID	PR:P31323 DAG View
PRO Name	cAMP-dependent protein kinase type II-beta regulatory subunit (human)
Definition	A cAMP-dependent protein kinase type II-beta regulatory subunit that is encoded in the genome of human.
Short Label	hPRKAR2B
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P31323 (PRKAR2B) as Substrate

P31323

Expanded View

	Site	PTM Type	PTM Enzyme	Score	Source	PMID
	T69	Phosphorylation		score4	HPRD PhosphoSitePlus RLIMS-P UniProt	19664994, 8516283, 23186163, ...19664995
	S71	Phosphorylation		score1	PhosphoSitePlus
	S83	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	19413330, 21406692
	S85	Phosphorylation		score2	HPRD PhosphoSitePlus UniProt	19413330, 21406692
	S114	Phosphorylation	P31323 (PRKAR2B) , P17612 (PRKACA)	score4	HPRD neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	21406692, 23186163, 19664995, ...18318008, 19651622, 7479855, 20166139, 33608270, 19690332, 15822905, 15187164
	C116	S-Nitrosylation		score0	dbSNO	26338901
	Y120	Phosphorylation		score1	PhosphoSitePlus
	K137	Ubiquitination		score1	PhosphoSitePlus
	K150	Ubiquitination		score1	PhosphoSitePlus
	T357	Phosphorylation		score1	PhosphoSitePlus
	K359	Ubiquitination		score1	PhosphoSitePlus
	K372	Ubiquitination		score1	PhosphoSitePlus
	T417	Phosphorylation		score1	PhosphoSitePlus

P31323 (PRKAR2B) as PTM Enzyme

Protein as Phosphorylation Enzyme

	Substrate	Site	Score	Source	PMID
	P31323 (PRKAR2B)	S114	score2	HPRD	19651622, 20166139, 7479855, ...19664995
	Q14847-1 (LASP1)	S99	score2	HPRD	12432067, 20068231
	Q14847-1 (LASP1)	S146	score2	HPRD	17287340, 18212344, 12571245, ...18077418, 18669648, 20166139, 18088087, 20068231

PTM sites affected in variants

Site	Variant	Source	PMID	Disease [Sample source]
C116	Y116	Biomuta		DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
K150	*	Biomuta		DOID:1324 / lung cancer [ cosmic ]
T417	I417	Biomuta		DOID:363 / uterine cancer [ cosmic, icgc ]