Protein Information

Cytoscape View


UniProt AC / UniProt ID P31321 / KAP1_HUMAN
Protein Name cAMP-dependent protein kinase type I-beta regulatory subunit
Gene Name Name: PRKAR1B
Organism Homo sapiens (Human)

PRO ID PR:P31321
DAG View
PRO Name cAMP-dependent protein kinase type I-beta regulatory subunit (human)
Definition A cAMP-dependent protein kinase type I-beta regulatory subunit that is encoded in the genome of human.
Short Label hPRKAR1B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31321 (PRKAR1B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S3 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
S9 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
S71 Phosphorylation HPRD   PhosphoSitePlus 18691976
S73 Phosphorylation PhosphoSitePlus
S75 Phosphorylation HPRD   PhosphoSitePlus 18691976, 18669648
S77 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18669648
S83 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163, 18669648, ...24275569, 19690332
T85 Phosphorylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
Y207 Phosphorylation PhosphoSitePlus
T209 Phosphorylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
S238 Phosphorylation PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
Y246 Phosphorylation PhosphoSitePlus
S251 Phosphorylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus
Y312 Phosphorylation PhosphoSitePlus
T338 Phosphorylation PhosphoSitePlus
R342 Methylation PhosphoSitePlus
K346 Ubiquitination PhosphoSitePlus
K349 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S3 F3 Biomuta DOID:1324 / lung cancer [ tcga ]
S9 * Biomuta DOID:8618 / oral cavity cancer [ icgc ]
S71 L71 Biomuta DOID:4362 / cervical cancer [ tcga ]
S73 * Biomuta DOID:4362 / cervical cancer [ tcga ]
S77 F77 Biomuta DOID:1909 / melanoma [ tcga ] DOID:1324 / lung cancer [ icgc, tcga ]
T85 N85 Biomuta DOID:3571 / liver cancer [ icgc ]
T239 M239 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3070 / malignant glioma [ cosmic, icgc ]