iPTMnet Report for P31153 (MAT2A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P31153 / METK2_HUMAN
Protein Name S-adenosylmethionine synthase isoform type-2
Gene Name Name: MAT2A
Synonyms:AMS2,MATA2;
Organism Homo sapiens (Human)

PRO ID PR:P31153
DAG View
PRO Name S-adenosylmethionine synthase isoform type-2 (human)
Definition An S-adenosylmethionine synthetase isoform type-2 that is encoded in the genome of human.
Short Label hMAT2A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31153 (MAT2A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K53 Ubiquitination PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
K81 Acetylation PhosphoSitePlus   UniProt 19608861
K81 Ubiquitination PhosphoSitePlus
K88 Acetylation PhosphoSitePlus
K88 Ubiquitination PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
Y101 Phosphorylation PhosphoSitePlus
K102 Ubiquitination PhosphoSitePlus
C104 Methylation IEDB 31844290
C104 S-Nitrosylation dbSNO 26338901
S114 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
K163 Acetylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
T182 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 34019948, 32870666, 28510447, 33465208
R192 Methylation PhosphoSitePlus
K228 Ubiquitination PhosphoSitePlus
K234 Acetylation PhosphoSitePlus
K234 Ubiquitination PhosphoSitePlus
Y235 Phosphorylation PhosphoSitePlus
Y242 Phosphorylation PhosphoSitePlus
T262 Phosphorylation PhosphoSitePlus
T270 Phosphorylation IEDB 32387766
S283 O-Glycosylation GlyGen 33465208
K285 Ubiquitination PhosphoSitePlus
T288 O-Glycosylation GlyGen 23301498, 33214551, 35138101, ...34725712, 34019948, 32870666, 28510447, 33465208
K289 Ubiquitination PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
K303 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
S319 Phosphorylation PhosphoSitePlus
Y320 Phosphorylation PhosphoSitePlus
K340 Sumoylation PhosphoSitePlus
K350 Ubiquitination PhosphoSitePlus
K351 Ubiquitination PhosphoSitePlus
K367 Ubiquitination PhosphoSitePlus
K368 Sumoylation PhosphoSitePlus
K368 Ubiquitination PhosphoSitePlus
Y377 Phosphorylation PhosphoSitePlus
S384 Phosphorylation PhosphoSitePlus   UniProt 23186163
K394 Sumoylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S114 Phosphorylation HPRD 18669648
T262 Phosphorylation HPRD 20068231
S384 Phosphorylation HPRD 19664994


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K228 R228 Biomuta DOID:9256 / colorectal cancer [ icgc ]
K340 M340 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
K340 N340 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K351 N351 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]