Protein Information

Cytoscape View


UniProt AC / UniProt ID P31152 / MK04_HUMAN
Protein Name Mitogen-activated protein kinase 4
Gene Name Name: MAPK4
Synonyms:ERK4,PRKM4;
Organism Homo sapiens (Human)

PRO ID PR:P31152
DAG View
PRO Name mitogen-activated protein kinase 4 (human)
Definition A mitogen-activated protein kinase 4 that is encoded in the genome of human.
Short Label hMAPK4
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P31152 (MAPK4) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K50 Ubiquitination PhosphoSitePlus
S58 Phosphorylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K138 Ubiquitination PhosphoSitePlus
S142 Phosphorylation PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
S186 Phosphorylation Q8IW41 (MAPKAPK5) , Q13177 (PAK2) HPRD   neXtProt   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21177870, 1319925, 18669648, ...18248330, 28252035
S196 Phosphorylation P31152 (MAPK4) HPRD   phospho.ELM 1319925
Y206 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
T294 Phosphorylation PhosphoSitePlus
S316 Phosphorylation PhosphoSitePlus
S386 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
S414 Phosphorylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
Y424 Phosphorylation PhosphoSitePlus
S427 Phosphorylation PhosphoSitePlus
K431 Ubiquitination PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus   UniProt 23186163
K447 Ubiquitination PhosphoSitePlus
T472 Phosphorylation PhosphoSitePlus
T479 Phosphorylation PhosphoSitePlus
K548 Ubiquitination PhosphoSitePlus
K560 Ubiquitination PhosphoSitePlus


P31152 (MAPK4) as PTM Enzyme



Substrate Site Score Source PMID
P31152 (MAPK4) S196 HPRD   phospho.ELM 1319925
Q8IW41 (MAPKAPK5) T182 neXtProt 19473979


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048323 (hMAPK4/Phos:1) pS186 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P31749 (AKT1) T308 P31152 (MAPK4) unknown eFIP 30688659


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K138 N138 Biomuta DOID:1324 / lung cancer [ cosmic ]
K138 R138 Biomuta DOID:1324 / lung cancer [ tcga ]
S142 C142 Biomuta DOID:1324 / lung cancer [ tcga ]
K182 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S186 L186 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
S386 L386 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S414 * Biomuta DOID:1324 / lung cancer [ tcga ]
S415 T415 Biomuta DOID:1909 / melanoma [ tcga ]
S427 T427 Biomuta DOID:363 / uterine cancer [ tcga ]
S427 F427 Biomuta DOID:363 / uterine cancer [ tcga ]
S434 L434 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S434 T434 Biomuta DOID:363 / uterine cancer [ tcga ]
K447 E447 Biomuta DOID:363 / uterine cancer [ tcga ] DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
T479 P479 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]