iPTMnet Report P31152 MAPK4

UniProt AC / UniProt ID	P31152 / MK04_HUMAN
Protein Name	Mitogen-activated protein kinase 4
Gene Name	Name: MAPK4 Synonyms:ERK4,PRKM4;
Organism	Homo sapiens (Human)

PRO ID	PR:P31152 DAG View
PRO Name	mitogen-activated protein kinase 4 (human)
Definition	A mitogen-activated protein kinase 4 that is encoded in the genome of human.
Short Label	hMAPK4
Category	organism-gene

	Select/align proteoforms across species

Expanded View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
K50	Ubiquitination		score1	PhosphoSitePlus
S58	Phosphorylation		score1	PhosphoSitePlus
K87	Ubiquitination		score1	PhosphoSitePlus
K138	Ubiquitination		score1	PhosphoSitePlus
S142	Phosphorylation		score1	PhosphoSitePlus
K182	Ubiquitination		score1	PhosphoSitePlus
S186	Phosphorylation	Q8IW41 (MAPKAPK5) , Q13177 (PAK2)	score4	HPRD neXtProt PRO PhosphoSitePlus RLIMS-P Signor UniProt	21177870, 1319925, 18669648, ...18248330, 28252035
S196	Phosphorylation	P31152 (MAPK4)	score3	HPRD phospho.ELM	1319925
Y206	Phosphorylation		score1	PhosphoSitePlus
K276	Ubiquitination		score1	PhosphoSitePlus
T294	Phosphorylation		score1	PhosphoSitePlus
S316	Phosphorylation		score1	PhosphoSitePlus
S386	Phosphorylation		score1	PhosphoSitePlus
S412	Phosphorylation		score1	PhosphoSitePlus
S414	Phosphorylation		score1	PhosphoSitePlus
S415	Phosphorylation		score1	PhosphoSitePlus
Y424	Phosphorylation		score1	PhosphoSitePlus
S427	Phosphorylation		score1	PhosphoSitePlus
K431	Ubiquitination		score1	PhosphoSitePlus
S434	Phosphorylation		score2	PhosphoSitePlus UniProt	23186163
K447	Ubiquitination		score1	PhosphoSitePlus
T472	Phosphorylation		score1	PhosphoSitePlus
T479	Phosphorylation		score1	PhosphoSitePlus
K548	Ubiquitination		score1	PhosphoSitePlus
K560	Ubiquitination		score1	PhosphoSitePlus

	Substrate	Site	Score	Source	PMID
	P31152 (MAPK4)	S196	score3	HPRD phospho.ELM	1319925
	Q8IW41 (MAPKAPK5)	T182	score2	neXtProt	19473979

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000048323 (hMAPK4/Phos:1)	pS186		PRO

	PTM type	Substrate	Site	Interactant	Association type	Source	PMID
	Phosphorylation	P31749 (AKT1)	T308	P31152 (MAPK4)	unknown	eFIP	30688659

Site	Variant	Source	Disease [Sample source]
S58	N58	Biomuta	DOID:4159 / skin cancer [ cosmic ]
K138	N138	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
K138	R138	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
S142	C142	Biomuta	DOID:1324 / lung cancer [ cosmic, icgc ]
K182	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S186	L186	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K276	Q276	Biomuta	DOID:1612 / breast cancer [ cosmic ]
S386	L386	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S412	L412	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
S415	T415	Biomuta	DOID:4159 / skin cancer [ cosmic, icgc ]
S427	T427	Biomuta	DOID:363 / uterine cancer [ icgc ]
S427	F427	Biomuta	DOID:363 / uterine cancer [ icgc ]
S434	L434	Biomuta	DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S434	T434	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
K447	E447	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
T479	P479	Biomuta	DOID:3571 / liver cancer [ cosmic ]

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iPTMnet Report for P31152 (MAPK4)