Protein Information

Cytoscape View

UniProt AC / UniProt ID P31040 / SDHA_HUMAN
Protein Name Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial precursor
Gene Name Name: SDHA
Organism Homo sapiens (Human)

PRO ID PR:P31040
DAG View
PRO Name succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (human)
Definition A succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial that is encoded in the genome of human.
Short Label hSDHA
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P31040 (SDHA) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T24 Phosphorylation PhosphoSitePlus
K41 Ubiquitination PhosphoSitePlus
K92 Acetylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K167 Ubiquitination PhosphoSitePlus
S177 Phosphorylation PhosphoSitePlus
K179 Acetylation PhosphoSitePlus   UniProt 19608861
K179 Ubiquitination PhosphoSitePlus
Y215 Phosphorylation P12931 (SRC) PhosphoSitePlus   RLIMS-P   UniProt 22823520
S243 Phosphorylation PhosphoSitePlus
K250 Ubiquitination PhosphoSitePlus
S321 Phosphorylation PhosphoSitePlus
K335 Acetylation PhosphoSitePlus   UniProt 19608861
K335 Ubiquitination PhosphoSitePlus
K361 Acetylation PhosphoSitePlus
Y365 Phosphorylation PhosphoSitePlus
K418 Ubiquitination PhosphoSitePlus
Y436 Phosphorylation PhosphoSitePlus
S456 Phosphorylation PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
K498 Acetylation PhosphoSitePlus
K498 Ubiquitination PhosphoSitePlus
R500 Methylation PhosphoSitePlus
R507 Methylation PhosphoSitePlus
R512 Methylation PhosphoSitePlus
K517 Ubiquitination PhosphoSitePlus
S530 Phosphorylation PhosphoSitePlus
K538 Ubiquitination PhosphoSitePlus
K541 Acetylation PhosphoSitePlus   UniProt 19608861
K541 Ubiquitination PhosphoSitePlus
Y543 Phosphorylation P09769 (FGR) neXtProt 17997986
K547 Acetylation PhosphoSitePlus
K547 Methylation PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
R585 Methylation PhosphoSitePlus
R589 Methylation PhosphoSitePlus
R594 Methylation PhosphoSitePlus
K598 Acetylation PhosphoSitePlus
Y604 Phosphorylation P09769 (FGR) neXtProt   PhosphoSitePlus 17997986
Y606 Phosphorylation PhosphoSitePlus
K608 Acetylation PhosphoSitePlus   UniProt 19608861
K608 Ubiquitination PhosphoSitePlus
K616 Ubiquitination PhosphoSitePlus
K624 Acetylation PhosphoSitePlus
K624 Ubiquitination PhosphoSitePlus
S628 Phosphorylation PhosphoSitePlus
Y629 Phosphorylation PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
R662 Methylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T24 Phosphorylation HPRD 20068231
T28 Phosphorylation HPRD 20068231
T30 Phosphorylation HPRD 20068231

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y215 C215 Biomuta DOID:3571 / liver cancer [ icgc ]
K250 E250 Biomuta DOID:184 / bone cancer [ icgc ] DOID:3371 / chondrosarcoma [ cosmic ]
S456 L456 Biomuta DOID:9256 / colorectal cancer [ icgc ]
R512 L512 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
R585 W585 Biomuta DOID:9256 / colorectal cancer [ tcga ]
R585 Q585 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
R589 Q589 Biomuta DOID:9256 / colorectal cancer [ icgc, tcga ] DOID:1909 / melanoma [ cosmic ]
Y606 H606 Biomuta DOID:4362 / cervical cancer [ tcga ] DOID:3963 / thyroid carcinoma [ icgc ]