iPTMnet Report for P30876 (POLR2B)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P30876 / RPB2_HUMAN
Protein Name DNA-directed RNA polymerase II subunit RPB2
Gene Name Name: POLR2B
Organism Homo sapiens (Human)

PRO ID PR:P30876
DAG View
PRO Name DNA-directed RNA polymerase II subunit RPB2 (human)
Definition A DNA-directed RNA polymerase II subunit RPB2 that is encoded in the genome of human.
Short Label hPOLR2B
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30876 (POLR2B) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K37 Ubiquitination PhosphoSitePlus
S75 Phosphorylation PhosphoSitePlus
K87 Ubiquitination PhosphoSitePlus
K95 Ubiquitination PhosphoSitePlus
S106 Phosphorylation PhosphoSitePlus
Y125 Phosphorylation PhosphoSitePlus
K130 Ubiquitination PhosphoSitePlus
K134 Ubiquitination PhosphoSitePlus
K146 Ubiquitination PhosphoSitePlus
T147 Phosphorylation PhosphoSitePlus
K151 Ubiquitination PhosphoSitePlus
C172 Methylation IEDB 31844290
K199 Ubiquitination PhosphoSitePlus
K210 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
S213 Phosphorylation HPRD 20068231
K214 Ubiquitination PhosphoSitePlus
Y215 Phosphorylation PhosphoSitePlus
Y217 Phosphorylation PhosphoSitePlus
T218 Phosphorylation HPRD   PhosphoSitePlus 20068231
C221 Methylation IEDB 31844290
K248 Ubiquitination PhosphoSitePlus
K249 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
K337 Ubiquitination PhosphoSitePlus
K340 Ubiquitination PhosphoSitePlus
K345 Ubiquitination PhosphoSitePlus
S354 Phosphorylation PhosphoSitePlus
T359 Phosphorylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K361 Ubiquitination PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K413 Ubiquitination PhosphoSitePlus
K421 Ubiquitination PhosphoSitePlus
K427 Ubiquitination PhosphoSitePlus
K436 Ubiquitination PhosphoSitePlus
T437 Phosphorylation PhosphoSitePlus
K445 Methylation PhosphoSitePlus
K445 Ubiquitination PhosphoSitePlus
K457 Ubiquitination PhosphoSitePlus
K458 Acetylation PhosphoSitePlus
K458 Ubiquitination PhosphoSitePlus
S467 Phosphorylation PhosphoSitePlus
S487 Phosphorylation PhosphoSitePlus
K494 Ubiquitination PhosphoSitePlus
K497 Ubiquitination PhosphoSitePlus
K578 Ubiquitination PhosphoSitePlus
T586 Phosphorylation PhosphoSitePlus
C622 Methylation IEDB 31844290
K630 Ubiquitination PhosphoSitePlus
K632 Ubiquitination PhosphoSitePlus
K637 Ubiquitination PhosphoSitePlus
K644 Ubiquitination PhosphoSitePlus
Y689 Phosphorylation PhosphoSitePlus
C696 Methylation IEDB 31844290
Y724 Phosphorylation PhosphoSitePlus
K730 Methylation PhosphoSitePlus
K730 Ubiquitination PhosphoSitePlus
Y736 Phosphorylation PhosphoSitePlus
Y752 Phosphorylation PhosphoSitePlus
K756 Ubiquitination PhosphoSitePlus
S763 Phosphorylation PhosphoSitePlus
R803 Methylation PhosphoSitePlus
K815 Acetylation PhosphoSitePlus
K815 Ubiquitination PhosphoSitePlus
K820 Acetylation PhosphoSitePlus
K821 Ubiquitination PhosphoSitePlus
K831 Ubiquitination PhosphoSitePlus
Y845 Phosphorylation PhosphoSitePlus
K847 Ubiquitination PhosphoSitePlus
K869 Ubiquitination PhosphoSitePlus
T870 Phosphorylation PhosphoSitePlus
T872 Phosphorylation PhosphoSitePlus
K889 Ubiquitination PhosphoSitePlus
K917 Ubiquitination PhosphoSitePlus
C919 Methylation IEDB 31844290
K920 Ubiquitination PhosphoSitePlus
K934 Ubiquitination PhosphoSitePlus
S937 Phosphorylation PhosphoSitePlus   UniProt 23186163
K942 Ubiquitination PhosphoSitePlus
C945 Methylation IEDB 31844290
K988 Ubiquitination PhosphoSitePlus
K993 Sumoylation PhosphoSitePlus
K993 Ubiquitination PhosphoSitePlus
K1010 Ubiquitination PhosphoSitePlus
S1012 Phosphorylation HPRD   PhosphoSitePlus 20068231
S1016 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y1018 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y1020 Phosphorylation PhosphoSitePlus
R1023 Methylation PhosphoSitePlus
K1036 Ubiquitination PhosphoSitePlus
T1046 O-Glycosylation GlyGen 33214551, 30397120, 30379171, ...34725712, 29351928, 34019948, 28510447, 34229054
K1052 Methylation PhosphoSitePlus   UniProt 24129315
K1058 Ubiquitination PhosphoSitePlus
R1064 Methylation PhosphoSitePlus
C1093 Methylation IEDB 31844290
C1119 Methylation IEDB 31844290
K1143 Ubiquitination PhosphoSitePlus
S1147 Phosphorylation HPRD   PhosphoSitePlus 20068231
C1155 Methylation IEDB 31844290


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K95 M95 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S106 L106 Biomuta DOID:1540 / parathyroid carcinoma [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K134 E134 Biomuta DOID:3571 / liver cancer [ cosmic, icgc ]
K151 R151 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
C172 S172 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S213 F213 Biomuta DOID:4159 / skin cancer [ cosmic ]
C221 W221 Biomuta DOID:10283 / prostate cancer [ cosmic ]
K248 T248 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
K249 N249 Biomuta DOID:1324 / lung cancer [ cosmic ]
K361 T361 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S467 P467 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S487 Y487 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K497 N497 Biomuta DOID:1612 / breast cancer [ cosmic ]
K578 I578 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S763 T763 Biomuta DOID:4159 / skin cancer [ cosmic ]
R803 C803 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:4362 / cervical cancer [ icgc ]
R803 H803 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:4606 / bile duct cancer [ cosmic ]
K889 M889 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ] DOID:263 / kidney cancer [ cosmic, icgc ]
K889 E889 Biomuta DOID:263 / kidney cancer [ cosmic ]
K917 T917 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
K993 N993 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic, icgc ]
Y1018 C1018 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K1058 Q1058 Biomuta DOID:10283 / prostate cancer [ cosmic ]