iPTMnet Report for P30622 (CLIP1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P30622 / CLIP1_HUMAN
Protein Name CAP-Gly domain-containing linker protein 1
Gene Name Name: CLIP1
Synonyms:CYLN1,RSN;
Organism Homo sapiens (Human)

PRO ID PR:P30622
DAG View
PRO Name CAP-Gly domain-containing linker protein 1 (human)
Definition A CAP-Gly domain-containing linker protein 1 that is encoded in the genome of human.
Short Label hCLIP1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30622 (CLIP1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus
S20 O-Glycosylation GlyGen 35008409, 28510447, 35254053, ...30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092
T25 Phosphorylation PhosphoSitePlus   RLIMS-P 32491151
T36 O-Glycosylation GlyGen 35008409, 28510447, 35254053, ...30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092
S43 Phosphorylation PhosphoSitePlus
S44 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T45 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 32491151
S47 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S48 O-Glycosylation GlyGen 31373491
S48 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 20068231
T50 Phosphorylation PhosphoSitePlus   UniProt 23186163
T119 O-Glycosylation GlyGen 35008409, 28510447, 35254053, ...30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092
T139 O-Glycosylation GlyGen 35008409, 28510447, 35254053, ...30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092
T139 Phosphorylation PhosphoSitePlus
T140 O-Glycosylation GlyGen 35008409, 28510447, 35254053, ...30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092
T140 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
S143 O-Glycosylation GlyGen 35008409, 32938750, 35254053, ...30379171, 32574038, 34725712, 28510447, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092
S143 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 20068231
T146 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S147 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 18669648, 32491151
S158 Phosphorylation PhosphoSitePlus
S160 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S162 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T163 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S172 Phosphorylation PhosphoSitePlus
S180 Phosphorylation PhosphoSitePlus
T182 O-Glycosylation GlyGen 31373491
T182 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163, 16964243, ...16565220
S186 Phosphorylation PhosphoSitePlus
N187 N-Glycosylation GlyGen 23345538
T189 O-Glycosylation GlyGen 35008409, 28510447, 35254053, ...30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092
T189 Phosphorylation PhosphoSitePlus
T191 O-Glycosylation GlyGen 31373491
T191 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S193 Phosphorylation PhosphoSitePlus
S195 Phosphorylation IntAct   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 23186163, 16964243, 18669648, ...20664522, 19690332
S195 Phosphorylation P53350 (PLK1) PhosphoSitePlus   Signor 20664522
S197 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648
S200 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16083285, 23186163, 17081983, ...18669648, 24275569, 19690332, 20068231
S204 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 16083285, 23186163, 17081983, ...15302935, 18669648, 19690332, 20068231
T260 Phosphorylation PhosphoSitePlus
Y262 Phosphorylation PhosphoSitePlus
Y269 Phosphorylation PhosphoSitePlus
T279 Phosphorylation PhosphoSitePlus
S285 Phosphorylation PhosphoSitePlus
T286 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
T287 Phosphorylation neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P 18669648, 19687009, 24777477
T302 O-Glycosylation GlyGen 35008409, 28510447, 35254053, ...30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092
T303 O-Glycosylation GlyGen 31373491
S304 O-Glycosylation GlyGen 35008409, 28510447, 35254053, ...30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092
S306 O-Glycosylation GlyGen 31373491
S306 Phosphorylation PhosphoSitePlus
S310 Phosphorylation PhosphoSitePlus
S312 Phosphorylation neXtProt   PhosphoSitePlus   RLIMS-P   Signor 30487641, 20519438, 32491151, ...21749319, 24451569
S312 Phosphorylation P17252 (PRKCA) Signor 20519438
S312 Phosphorylation P53350 (PLK1) PhosphoSitePlus 24451569
S312 Phosphorylation Q16512 (PKN1) neXtProt   PhosphoSitePlus 21749319
S312 Phosphorylation Q6P5Z2 (PKN3) neXtProt   PhosphoSitePlus 21749319
S314 Phosphorylation PhosphoSitePlus
S315 Phosphorylation PhosphoSitePlus
S317 Phosphorylation PhosphoSitePlus
S320 Phosphorylation PhosphoSitePlus
S325 O-Glycosylation GlyGen 31373491
S325 Phosphorylation PhosphoSitePlus
S328 Phosphorylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
T339 O-Glycosylation GlyGen 31373491
S341 O-Glycosylation GlyGen 31373491
S348 Phosphorylation PhosphoSitePlus
T350 Phosphorylation PhosphoSitePlus
T351 Phosphorylation PhosphoSitePlus
K360 Ubiquitination PhosphoSitePlus
K409 Ubiquitination PhosphoSitePlus
T501 Phosphorylation PhosphoSitePlus
S510 Phosphorylation PhosphoSitePlus
K574 Ubiquitination PhosphoSitePlus
K589 Ubiquitination PhosphoSitePlus
S607 Phosphorylation PhosphoSitePlus
K647 Ubiquitination PhosphoSitePlus
K751 Ubiquitination PhosphoSitePlus
K767 Ubiquitination PhosphoSitePlus
S783 Phosphorylation PhosphoSitePlus
S784 Phosphorylation PhosphoSitePlus
S788 Phosphorylation PhosphoSitePlus
S815 Phosphorylation PhosphoSitePlus
T833 Phosphorylation PhosphoSitePlus
S840 Phosphorylation PhosphoSitePlus
S843 Phosphorylation PhosphoSitePlus
T848 Phosphorylation PhosphoSitePlus
K967 Ubiquitination PhosphoSitePlus
N971 N-Glycosylation GlyGen 23345538
S973 Phosphorylation PhosphoSitePlus
S989 O-Glycosylation GlyGen 35008409, 28510447, 35254053, ...30379171, 32574038, 34725712, 34019948, 28657654, 30059200, 35132862, 30620550, 31492838, 36240223, 29351928, 31373491, 29237092
K1007 Acetylation PhosphoSitePlus
S1009 Phosphorylation PhosphoSitePlus
K1013 Acetylation PhosphoSitePlus
S1066 Phosphorylation PhosphoSitePlus
T1087 Phosphorylation PhosphoSitePlus
S1140 Phosphorylation PhosphoSitePlus
S1169 Phosphorylation PhosphoSitePlus
S1230 Phosphorylation PhosphoSitePlus
S1234 Phosphorylation PhosphoSitePlus
S1236 Phosphorylation PhosphoSitePlus
S1239 Phosphorylation PhosphoSitePlus
K1245 Ubiquitination PhosphoSitePlus
N1263 N-Glycosylation GlyGen 23345538
S1302 Phosphorylation PhosphoSitePlus
S1303 Phosphorylation PhosphoSitePlus
S1304 Phosphorylation PhosphoSitePlus
S1305 Phosphorylation PhosphoSitePlus
T1308 Phosphorylation PhosphoSitePlus
T1310 Phosphorylation PhosphoSitePlus   UniProt 24275569
A1318 Phosphorylation IntAct 20664522
S1364 Phosphorylation PhosphoSitePlus   Signor   UniProt 20664522, 20068231
S1364 Phosphorylation P53350 (PLK1) PhosphoSitePlus 20664522
S1364 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 20664522
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
S7 Phosphorylation HPRD 20068231
T25 Phosphorylation HPRD 20068231
S43 Phosphorylation HPRD 20068231
S44 Phosphorylation HPRD 18669648
T45 Phosphorylation HPRD 18669648, 20068231, 18452278
S47 Phosphorylation HPRD 18669648
S48 Phosphorylation HPRD 18669648, 20068231
T140 Phosphorylation HPRD 18669648, 19691289, 20068231
S143 Phosphorylation HPRD 18669648, 20068231
T146 Phosphorylation HPRD 18669648, 20068231
S147 Phosphorylation HPRD 18669648, 18491316
S160 Phosphorylation HPRD 18669648
S162 Phosphorylation HPRD 18669648
T163 Phosphorylation HPRD 18669648
S172 Phosphorylation HPRD 18077418
S180 Phosphorylation HPRD 18077418
T182 Phosphorylation HPRD 19413330, 16964243, 19007248, ...16565220, 18669648, 20068231
T191 Phosphorylation HPRD 19651622, 18669648
S193 Phosphorylation HPRD 19413330
S195 Phosphorylation HPRD 19413330, 16964243, 18767875, ...18077418, 19664994, 19691289, 19651622, 18669648, 20068231
S197 Phosphorylation HPRD 18767875, 18669648, 20068231
S200 Phosphorylation HPRD 19413330, 16083285, 18767875, ...19664994, 19651622, 18669648, 19415658, 20068231
S204 Phosphorylation HPRD 19413330, 20058876, 15302935, ...19664994, 19664995, 19691289, 19651622, 18669648, 20166139, 15345747, 19415658, 20068231
S285 Phosphorylation HPRD 20068231
T286 Phosphorylation HPRD 18669648, 20068231
T287 Phosphorylation HPRD 18669648, 20068231
S310 Phosphorylation HPRD 20068231
S312 Phosphorylation HPRD 20068231
S315 Phosphorylation HPRD 20068231
S317 Phosphorylation HPRD 20068231
S328 Phosphorylation HPRD 20068231
S331 Phosphorylation HPRD 20068231
S348 Phosphorylation HPRD 20166139, 20068231
T351 Phosphorylation HPRD 20068231
S596 Phosphorylation HPRD 20068231
T822 Phosphorylation HPRD 18452278
S998 Phosphorylation HPRD 20068231
Y1351 Phosphorylation HPRD 18669648
S1353 Phosphorylation HPRD 19413330, 19651622, 18669648, ...20068231
Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation HPRD 20068231
S7 Phosphorylation HPRD 20068231
T13 Phosphorylation PhosphoSitePlus
T25 Phosphorylation HPRD 20068231
T27 Phosphorylation PhosphoSitePlus
T36 Phosphorylation PhosphoSitePlus
S43 Phosphorylation HPRD 20068231
S44 Phosphorylation HPRD 18669648
T45 Phosphorylation HPRD 18669648, 20068231, 18452278
S47 Phosphorylation HPRD 18669648
S48 Phosphorylation HPRD 18669648, 20068231
T140 Phosphorylation HPRD 18669648, 19691289, 20068231
S143 Phosphorylation HPRD 18669648, 20068231
T146 Phosphorylation HPRD 18669648, 20068231
S147 Phosphorylation HPRD 18669648, 18491316
S160 Phosphorylation HPRD 18669648
S162 Phosphorylation HPRD 18669648
T163 Phosphorylation HPRD 18669648
S172 Phosphorylation HPRD 18077418
S180 Phosphorylation HPRD 18077418
T182 Phosphorylation HPRD 19413330, 16964243, 19007248, ...16565220, 18669648, 20068231
T191 Phosphorylation HPRD   PhosphoSitePlus 19651622, 18669648
S193 Phosphorylation HPRD 19413330
S195 Phosphorylation HPRD   PhosphoSitePlus 19413330, 16964243, 18767875, ...18077418, 19664994, 19691289, 19651622, 18669648, 20068231
S197 Phosphorylation HPRD 18767875, 18669648, 20068231
S200 Phosphorylation HPRD 19413330, 16083285, 18767875, ...19664994, 19651622, 18669648, 19415658, 20068231
S204 Phosphorylation HPRD 19413330, 20058876, 15302935, ...19664994, 19664995, 19691289, 19651622, 18669648, 20166139, 15345747, 19415658, 20068231
S285 Phosphorylation HPRD 20068231
T286 Phosphorylation HPRD 18669648, 20068231
T287 Phosphorylation HPRD   PhosphoSitePlus 18669648, 20068231
S310 Phosphorylation HPRD 20068231
S312 Phosphorylation HPRD 20068231
S315 Phosphorylation HPRD 20068231
S317 Phosphorylation HPRD 20068231
S328 Phosphorylation HPRD 20068231
S331 Phosphorylation HPRD 20068231
S348 Phosphorylation HPRD 20166139, 20068231
T351 Phosphorylation HPRD 20068231
T459 Phosphorylation PhosphoSitePlus
K463 Ubiquitination PhosphoSitePlus
S561 Phosphorylation HPRD 20068231
T787 Phosphorylation HPRD 18452278
S963 Phosphorylation HPRD 20068231
T1099 Phosphorylation PhosphoSitePlus
S1188 Phosphorylation PhosphoSitePlus
S1190 Phosphorylation PhosphoSitePlus
S1225 Phosphorylation PhosphoSitePlus
Y1316 Phosphorylation HPRD 18669648
S1318 Phosphorylation HPRD   PhosphoSitePlus 19413330, 19651622, 18669648, ...20068231
T1384 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
N187 N-Glycosylation PRO 23345538
N971 N-Glycosylation PRO 23345538
N1263 N-Glycosylation PRO 23345538


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S44 I44 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S47 L47 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S47 * Biomuta DOID:1612 / breast cancer [ cosmic ]
S48 F48 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S143 C143 Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
S143 F143 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S147 L147 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S158 C158 Biomuta [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T182 M182 Biomuta [ cosmic ]
S186 N186 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic ]
S193 G193 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S193 N193 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ]
S200 L200 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
T303 M303 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S314 P314 Biomuta DOID:9256 / colorectal cancer [ cosmic, cosmic, cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
T848 N848 Biomuta DOID:2531 / hematologic cancer [ cosmic ]
S963 L963 Biomuta DOID:1319 / brain cancer [ icgc ]
S998 L998 Biomuta DOID:1319 / brain cancer [ icgc ]
T1099 I1099 Biomuta DOID:263 / kidney cancer [ cosmic ]
S1169 F1169 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1225 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
S1318 N1318 Biomuta [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc, cosmic, icgc, cosmic ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic, cosmic, cosmic, cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:1319 / brain cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic, cosmic, icgc, cosmic, icgc ]
S1353 N1353 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic, icgc ]
S1364 N1364 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]