Protein Information

Cytoscape View


UniProt AC / UniProt ID P30613 / KPYR_HUMAN
Protein Name Pyruvate kinase PKLR
Gene Name Name: PKLR
Synonyms:PK1,PKL;
Organism Homo sapiens (Human)

PRO ID PR:P30613
DAG View
PRO Name pyruvate kinase PKLR (human)
Definition A pyruvate kinase PKLR that is encoded in the genome of human.
Short Label hPKLR
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30613 (PKLR) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Phosphorylation PhosphoSitePlus   UniProt 23186163
S8 Phosphorylation PhosphoSitePlus
S19 Phosphorylation PhosphoSitePlus   UniProt 23186163
S26 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y38 Phosphorylation PhosphoSitePlus
S43 Phosphorylation PhosphoSitePlus   UniProt 24275569
S144 Phosphorylation PhosphoSitePlus
K158 Ubiquitination PhosphoSitePlus
Y218 Phosphorylation PhosphoSitePlus
K290 Methylation PhosphoSitePlus
S292 Phosphorylation PhosphoSitePlus   UniProt 24275569
K313 Ubiquitination PhosphoSitePlus
K348 Acetylation PhosphoSitePlus
K348 Ubiquitination PhosphoSitePlus
K354 Acetylation PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
T388 Phosphorylation PhosphoSitePlus
T556 Phosphorylation PhosphoSitePlus
S562 Phosphorylation PhosphoSitePlus
Y564 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S26 Phosphorylation HPRD 20068231
S292 Phosphorylation HPRD 20068230
T556 Phosphorylation HPRD 17081983
Site PTM Type PTM Enzyme Score Source PMID
S12 Phosphorylation PhosphoSitePlus
S261 Phosphorylation HPRD 20068230
T525 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S2 L2 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ] DOID:11934 / head and neck cancer [ tcga ] DOID:11054 / urinary bladder cancer [ tcga ]
S43 T43 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc, tcga ]
K158 Q158 Biomuta DOID:1612 / breast cancer [ icgc, tcga ]
K158 N158 Biomuta DOID:363 / uterine cancer [ tcga ]
T388 K388 Biomuta DOID:1115 / sarcoma [ tcga ]