iPTMnet Report for P30566 (ADSL)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P30566 / PUR8_HUMAN
Protein Name Adenylosuccinate lyase
Gene Name Name: ADSL
Synonyms:AMPS;
Organism Homo sapiens (Human)

PRO ID PR:P30566
DAG View
PRO Name adenylosuccinate lyase (human)
Definition An adenylosuccinate lyase that is encoded in the genome of human.
Short Label hADSL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30566 (ADSL) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation PhosphoSitePlus
S12 Phosphorylation PhosphoSitePlus
S15 Phosphorylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K82 Acetylation PhosphoSitePlus
T94 Phosphorylation PhosphoSitePlus
T111 Phosphorylation PhosphoSitePlus
C113 Methylation IEDB 31844290
K134 Ubiquitination PhosphoSitePlus
K147 Acetylation PhosphoSitePlus   UniProt 19608861
K147 Ubiquitination PhosphoSitePlus
K170 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K218 Ubiquitination PhosphoSitePlus
K224 Ubiquitination PhosphoSitePlus
K229 Ubiquitination PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus
K276 Ubiquitination PhosphoSitePlus
K284 Ubiquitination PhosphoSitePlus
Y294 Phosphorylation PhosphoSitePlus
K295 Acetylation PhosphoSitePlus   UniProt 19608861
K295 Ubiquitination PhosphoSitePlus
K391 Ubiquitination PhosphoSitePlus
K402 Ubiquitination PhosphoSitePlus
S407 Phosphorylation PhosphoSitePlus
S412 Phosphorylation PhosphoSitePlus
K415 Sumoylation PhosphoSitePlus
K415 Ubiquitination PhosphoSitePlus
S434 Phosphorylation PhosphoSitePlus
S438 Phosphorylation PhosphoSitePlus
Y466 Phosphorylation PhosphoSitePlus
K470 Ubiquitination PhosphoSitePlus
K479 Ubiquitination PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S9 Phosphorylation HPRD 19413330, 18691976, 19651622, ...20068231
S12 Phosphorylation HPRD 19651622, 20068231
S15 Phosphorylation HPRD 19651622


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S9 L9 Biomuta DOID:1612 / breast cancer [ cosmic ]
K134 N134 Biomuta DOID:1324 / lung cancer [ cosmic ]
K402 T402 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S407 F407 Biomuta DOID:4159 / skin cancer [ cosmic ]
K470 I470 Biomuta DOID:1319 / brain cancer [ cosmic ]