Protein Information

Cytoscape View

UniProt AC / UniProt ID P30530 / UFO_HUMAN
Protein Name Tyrosine-protein kinase receptor UFO precursor
Gene Name Name: AXL
Organism Homo sapiens (Human)

PRO ID PR:P30530
DAG View
PRO Name tyrosine-protein kinase receptor UFO (human)
Definition A tyrosine-protein kinase receptor UFO that is encoded in the genome of human.
Short Label hAXL
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P30530 (AXL) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
N40 N-Glycosylation GlyGen 29391424
S100 Phosphorylation PhosphoSitePlus
N198 N-Glycosylation GlyGen 23090970, 30237853, 24190977
T200 Phosphorylation PhosphoSitePlus
S201 Phosphorylation PhosphoSitePlus
S202 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus
T303 Phosphorylation PhosphoSitePlus
N345 N-Glycosylation GlyGen 29391424
Y481 Phosphorylation PhosphoSitePlus
S503 Phosphorylation PhosphoSitePlus
S515 Phosphorylation PhosphoSitePlus
K523 Ubiquitination PhosphoSitePlus
K525 Ubiquitination PhosphoSitePlus
K535 Ubiquitination PhosphoSitePlus
K540 Ubiquitination PhosphoSitePlus
K563 Ubiquitination PhosphoSitePlus
K570 Ubiquitination PhosphoSitePlus
S612 Phosphorylation PhosphoSitePlus
Y634 Phosphorylation PhosphoSitePlus
Y643 Phosphorylation PhosphoSitePlus
K666 Ubiquitination PhosphoSitePlus
S694 Phosphorylation PhosphoSitePlus
K696 Ubiquitination PhosphoSitePlus
Y698 Phosphorylation PhosphoSitePlus   RLIMS-P 33040087
Y702 Phosphorylation PhosphoSitePlus   RLIMS-P 33283192, 33040087, 33203881, ...30647852, 27829217, 27102439, 31269715
Y703 Phosphorylation PhosphoSitePlus   RLIMS-P 33040087, 30647852
K710 Ubiquitination PhosphoSitePlus
K714 Ubiquitination PhosphoSitePlus
R724 Methylation PhosphoSitePlus
Y726 Phosphorylation PhosphoSitePlus
Y759 Phosphorylation PhosphoSitePlus
Y779 Phosphorylation P30530 (AXL) , P00533 (EGFR) IntAct   PRO   PhosphoSitePlus   RLIMS-P+   RLIMS-P   UniProt 26580964, 9178760, 27775700, ...28675785, 26313459, 32952632, 27829217, 32058975, 18346204, 31723838
Y821 Phosphorylation P30530 (AXL) IntAct   PRO   PhosphoSitePlus   UniProt 9178760, 18346204
S853 Phosphorylation PhosphoSitePlus
Y866 Phosphorylation P30530 (AXL) PhosphoSitePlus   UniProt 9178760, 18346204
T873 Phosphorylation PhosphoSitePlus
S875 Phosphorylation PhosphoSitePlus
S884 Phosphorylation PhosphoSitePlus   UniProt 18691976
Site PTM Type PTM Enzyme Score Source PMID
Y481 Phosphorylation HPRD 18707149
Y702 Phosphorylation HPRD 17016520
Y779 Phosphorylation P30530 (AXL) HPRD 9178760
Y821 Phosphorylation P30530 (AXL) HPRD 9178760
Y866 Phosphorylation P30530 (AXL) HPRD 17389395, 9178760
S875 Phosphorylation HPRD 18691976
S884 Phosphorylation HPRD 18691976
Site PTM Type PTM Enzyme Score Source PMID
Y472 Phosphorylation HPRD 18707149
Y693 Phosphorylation HPRD 17016520
Y770 Phosphorylation HPRD 9178760
Y812 Phosphorylation HPRD 9178760
Y857 Phosphorylation HPRD 17389395, 9178760
S866 Phosphorylation HPRD 18691976
S875 Phosphorylation HPRD 18691976

P30530 (AXL) as PTM Enzyme

Substrate Site Score Source PMID
P30530-1 (AXL) Y779 HPRD   UniProt 9178760, 18346204
P30530 (AXL) Y821 HPRD   UniProt 9178760, 18346204
P30530 (AXL) Y866 HPRD   UniProt 17389395, 18346204, 9178760


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000046450 (hAXL/SigPep-/Phos:1) pY779,pY821 PRO

PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P30530 (AXL) Y821 P27986 (PIK3R1) unknown eFIP 9178760
Phosphorylation P30530 (AXL) Y779 P62993 (GRB2) unknown eFIP 9178760
Phosphorylation P30530 (AXL) Y821 P19174 (PLCG1) unknown eFIP 9178760
Phosphorylation Q96JJ3 (ELMO2) Y713 P30530 (AXL) unknown eFIP 25332238

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T200 A200 Biomuta DOID:1612 / breast cancer [ cosmic, icgc, tcga ]
S201 F201 Biomuta DOID:363 / uterine cancer [ tcga ]
K535 N535 Biomuta DOID:1324 / lung cancer [ cosmic ]
K570 N570 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
S612 I612 Biomuta DOID:3571 / liver cancer [ icgc ]
Y703 * Biomuta DOID:1612 / breast cancer [ icgc ] DOID:1324 / lung cancer [ tcga ] DOID:3070 / malignant glioma [ tcga ] DOID:2394 / ovarian cancer [ tcga ]
Y726 H726 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y866 C866 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]