iPTMnet Report for P30520 (ADSS2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P30520 / PURA2_HUMAN
Protein Name Adenylosuccinate synthetase isozyme 2
Gene Name Name: ADSS2
Synonyms:ADSS;
Organism Homo sapiens (Human)

PRO ID PR:P30520
DAG View
PRO Name adenylosuccinate synthetase isozyme 2 (human)
Definition An adenylosuccinate synthetase isozyme 2 that is encoded in the genome of human.
Short Label hADSS2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30520 (ADSS2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
T6 Phosphorylation PhosphoSitePlus
K45 Ubiquitination PhosphoSitePlus
K118 Ubiquitination PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
K157 Ubiquitination PhosphoSitePlus
K164 Ubiquitination PhosphoSitePlus
Y170 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
K203 Ubiquitination PhosphoSitePlus
Y223 Phosphorylation PhosphoSitePlus
Y236 Phosphorylation PhosphoSitePlus
Y239 Phosphorylation PhosphoSitePlus
K397 Ubiquitination PhosphoSitePlus
Y402 Phosphorylation PhosphoSitePlus
K403 Ubiquitination PhosphoSitePlus
T404 O-Glycosylation GlyGen 33214551, 35138101, 34725712, ...25367160, 34019948, 28510447, 34229054
S413 O-Glycosylation GlyGen 33214551, 35138101, 34725712, ...25367160, 34019948, 28510447, 34229054
K419 Acetylation PhosphoSitePlus
K419 Ubiquitination PhosphoSitePlus
K441 Ubiquitination PhosphoSitePlus
K447 Ubiquitination PhosphoSitePlus
S448 Phosphorylation PhosphoSitePlus
S451 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K397 T397 Biomuta DOID:363 / uterine cancer [ icgc ]
Y402 C402 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
S413 P413 Biomuta [ cosmic ]
K447 E447 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]