iPTMnet Report for P30519 (HMOX2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P30519 / HMOX2_HUMAN
Protein Name Heme oxygenase 2
Gene Name Name: HMOX2
Synonyms:HO2;
Organism Homo sapiens (Human)

PRO ID PR:P30519
DAG View
PRO Name heme oxygenase 2 (human)
Definition A heme oxygenase 2 that is encoded in the genome of human.
Short Label hHMOX2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30519 (HMOX2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S2 Acetylation UniProt 19413330, 25944712
S2 Phosphorylation PhosphoSitePlus   UniProt 23186163
S8 Phosphorylation PhosphoSitePlus
S14 Phosphorylation PhosphoSitePlus
K24 Ubiquitination PhosphoSitePlus
S34 Phosphorylation PhosphoSitePlus
K38 Ubiquitination PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
K59 Ubiquitination PhosphoSitePlus
C127 Methylation IEDB 31844290
Y157 Phosphorylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
Y202 Phosphorylation PhosphoSitePlus
K216 Acetylation PhosphoSitePlus
S242 O-Glycosylation GlyGen 34019948, 34229054, 29351928
T243 O-Glycosylation GlyGen 34019948, 34229054, 29351928
K259 Ubiquitination PhosphoSitePlus
K264 Ubiquitination PhosphoSitePlus
Y268 Phosphorylation PhosphoSitePlus
S280 Phosphorylation PhosphoSitePlus
C282 S-Nitrosylation dbSNO 22178444
T286 Phosphorylation PhosphoSitePlus
S295 Phosphorylation PhosphoSitePlus
Y314 Phosphorylation PhosphoSitePlus
Y315 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S79 Phosphorylation HPRD 14527438
S79 Phosphorylation P68400 (CSNK2A1) HPRD 14527438


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K38 N38 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K59 E59 Biomuta DOID:363 / uterine cancer [ cosmic ]
S79 * Biomuta DOID:11054 / urinary bladder cancer [ cosmic ]
Y202 C202 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]