iPTMnet Report for P30291 (WEE1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P30291 / WEE1_HUMAN
Protein Name Wee1-like protein kinase
Gene Name Name: WEE1
Organism Homo sapiens (Human)

PRO ID PR:P30291
DAG View
PRO Name Wee1-like protein kinase (human)
Definition A Wee1-like protein kinase that is encoded in the genome of human.
Short Label hWEE1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30291 (WEE1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
Phosphorylation PRO
R14 Methylation PhosphoSitePlus
S48 Phosphorylation PhosphoSitePlus
T49 Phosphorylation PhosphoSitePlus
S53 Phosphorylation P53350 (PLK1) neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15070733, 22479455, 16085715, ...15350223
S67 Phosphorylation PhosphoSitePlus
T69 Phosphorylation PhosphoSitePlus
S78 Phosphorylation PhosphoSitePlus
S85 Phosphorylation PhosphoSitePlus   UniProt 18691976
S121 Phosphorylation P68400 (CSNK2A1) phospho.ELM   PhosphoSitePlus   RLIMS-P 22479455, 16085715
S123 Phosphorylation P53350 (PLK1) , P06493 (CDK1) , P24941 (CDK2) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15070733, 22479455, 16085715, ...18560763, 23051732
S127 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 20068231
Y132 Phosphorylation PhosphoSitePlus
S137 Phosphorylation PhosphoSitePlus   UniProt 23186163
S139 Phosphorylation phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 23186163, 17081983, 18220336, ...15302935, 17192257, 19690332, 20068231, 23051732
S150 Phosphorylation PhosphoSitePlus   UniProt 18691976
S165 Phosphorylation phospho.ELM   PhosphoSitePlus 17081983
T173 Phosphorylation phospho.ELM   PhosphoSitePlus 17192257
T187 Phosphorylation PhosphoSitePlus   UniProt 23186163
T190 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163
S193 Phosphorylation PhosphoSitePlus
S196 Phosphorylation PhosphoSitePlus
R199 Methylation PhosphoSitePlus
K207 Ubiquitination PhosphoSitePlus
S211 Phosphorylation P49841 (GSK3B) PhosphoSitePlus 24817118
S212 Phosphorylation P48730 (CSNK1D) PhosphoSitePlus 24817118
T217 Phosphorylation PhosphoSitePlus
T239 Phosphorylation PhosphoSitePlus   RLIMS-P   UniProt 22692537, 25744022
S242 Phosphorylation PhosphoSitePlus
Y258 Phosphorylation PhosphoSitePlus
S262 Phosphorylation PhosphoSitePlus
S270 Phosphorylation PhosphoSitePlus   UniProt 23186163
Y272 Phosphorylation PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
S293 Phosphorylation PhosphoSitePlus
K304 Ubiquitination PhosphoSitePlus
S307 Phosphorylation PhosphoSitePlus   UniProt 23186163
S312 Phosphorylation PhosphoSitePlus   UniProt 18691976, 23186163
K315 Ubiquitination PhosphoSitePlus
C316 Methylation IEDB 31844290
S444 Phosphorylation PhosphoSitePlus
K460 Ubiquitination PhosphoSitePlus
S472 Phosphorylation PhosphoSitePlus
S480 Phosphorylation PhosphoSitePlus
K547 Ubiquitination PhosphoSitePlus
S571 Phosphorylation PhosphoSitePlus
S576 Phosphorylation PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
K590 Sumoylation PhosphoSitePlus
K590 Ubiquitination PhosphoSitePlus
K596 Ubiquitination PhosphoSitePlus
K600 Ubiquitination PhosphoSitePlus
R617 Methylation PhosphoSitePlus
S622 O-Glycosylation GlyGen 30379171
S642 Phosphorylation Q8IWQ3 (BRSK2) , Q8TDC3 (BRSK1) , P31749 (AKT1) neXtProt   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 24053672, 25283841, 15964826, ...29754473, 32410646, 29187878, 24381593, 22730174, 15150265, 33796458, 20026642
T644 Phosphorylation PhosphoSitePlus
Y646 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
S53 Phosphorylation P53350 (PLK1) HPRD 15070733
S67 Phosphorylation HPRD 18691976
S78 Phosphorylation HPRD 18691976
S85 Phosphorylation HPRD 18691976
S123 Phosphorylation HPRD 15070733, 18691976
S127 Phosphorylation HPRD 19651622, 18691976, 17081983, ...20068231
Y132 Phosphorylation HPRD 19651622
S136 Phosphorylation HPRD 18691976
S137 Phosphorylation HPRD 18691976
S139 Phosphorylation HPRD 18691976, 18767875, 19664995, ...19651622, 17322306, 20068231
S150 Phosphorylation HPRD 18691976
S165 Phosphorylation HPRD 19651622, 17081983
T173 Phosphorylation P30291 (WEE1) HPRD 19651622, 18691976, 17192257
T187 Phosphorylation HPRD 16964243
T190 Phosphorylation HPRD 18691976, 16964243
S211 Phosphorylation HPRD 15253423
S212 Phosphorylation HPRD 15253423
S312 Phosphorylation HPRD 18691976
S471 Phosphorylation HPRD 18691976
S559 Phosphorylation HPRD 15253423
S642 Phosphorylation Q8IWQ3 (BRSK2) , Q8TDC3 (BRSK1) HPRD 15150265


P30291 (WEE1) as PTM Enzyme



Substrate Site Score Source PMID
P06493-1 (CDK1) Y15 HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P+   Signor 8662825, 7743995, 10564259, ...16497976, 18691976, 7774574, 15964826, 19858290, 18669648, 18452278, 26673326, 19413330, 19901323, 8084605, 20058876, 19651622, 20372791, 8428596, 16096060, 17016520, 1850698, 19415658, 20068231
P07900 (HSP90AA1) Y38 PhosphoSitePlus 20159553
P24941 (CDK2) T14 PhosphoSitePlus 17283158
P24941-1 (CDK2) Y15 HPRD   PhosphoSitePlus   Signor 17016520, 18691976, 17389395, ...18212344, 11029659, 19664994, 17283158, 18452278, 7743995, 17095507, 9038181, 16497976
P30291-1 (WEE1) T173 HPRD 19651622, 18691976, 17192257


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049678 (hWEE1/Phos:1) pS53 PRO
PR:000049679 (hWEE1/PhosRes+) p PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P30291 (WEE1) S139 P53350 (PLK1) inhibited_association eFIP 23051732
Phosphorylation P30291 (WEE1) S123 Q9Y297 (BTRC) increased_association eFIP 16085715


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
T173 P173 Biomuta DOID:4159 / skin cancer [ cosmic ]
K292 N292 Biomuta DOID:1324 / lung cancer [ cosmic ]
S312 F312 Biomuta DOID:4159 / skin cancer [ cosmic ]
K588 Q588 Biomuta DOID:263 / kidney cancer [ cosmic ]
S642 I642 Biomuta [ cosmic ] DOID:1115 / sarcoma [ icgc ]
Y646 C646 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]