Protein Information

Cytoscape View

UniProt AC / UniProt ID P30279 / CCND2_HUMAN
Protein Name G1/S-specific cyclin-D2
Gene Name Name: CCND2
Organism Homo sapiens (Human)

PRO ID PR:P30279
DAG View
PRO Name G1/S-specific cyclin-D2 (human)
Definition A G1/S-specific cyclin-D2 that is encoded in the genome of human.
Short Label hCCND2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P30279 (CCND2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
K45 Ubiquitination PhosphoSitePlus
K49 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
K244 Ubiquitination PhosphoSitePlus
S269 Phosphorylation PhosphoSitePlus
S271 Phosphorylation PhosphoSitePlus   UniProt 23186163
S279 Phosphorylation PhosphoSitePlus
T280 Phosphorylation Q16539 (MAPK14) , P49841 (GSK3B) neXtProt   PhosphoSitePlus   Signor 17486076, 24705253
T282 Phosphorylation PhosphoSitePlus

P30279 (CCND2) as PTM Enzyme

Substrate Site Score Source PMID
P06400 (RB1) S780 HPRD 19651622, 9003781, 11254678, ...16326706

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S271 L271 Biomuta DOID:1909 / melanoma [ tcga ]
T280 A280 Biomuta DOID:2531 / hematologic cancer [ icgc ]
T280 N280 Biomuta DOID:2531 / hematologic cancer [ icgc ]