iPTMnet Report for P30260 (CDC27)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P30260 / CDC27_HUMAN
Protein Name Cell division cycle protein 27 homolog
Gene Name Name: CDC27
Synonyms:ANAPC3,D0S1430E,D17S978E;
Organism Homo sapiens (Human)

PRO ID PR:P30260
DAG View
PRO Name cell division cycle protein 27 homolog (human)
Definition A cell division cycle protein 27 that is encoded in the genome of human.
Short Label hCDC27
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30260 (CDC27) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K62 Ubiquitination PhosphoSitePlus
T68 Phosphorylation PhosphoSitePlus
C71 Methylation IEDB 31844290
K72 Ubiquitination PhosphoSitePlus
K77 Acetylation PhosphoSitePlus
K77 Ubiquitination PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
K99 Ubiquitination PhosphoSitePlus
C115 Methylation IEDB 31844290
C126 Methylation IEDB 31844290
K133 Ubiquitination PhosphoSitePlus
C137 Methylation IEDB 31844290
Y138 Phosphorylation RLIMS-P 32368092
S143 Phosphorylation RLIMS-P 32368092
S150 Phosphorylation RLIMS-P 32368092
S154 Phosphorylation PhosphoSitePlus   Signor 21209074
S154 Phosphorylation P68400 (CSNK2A1) PhosphoSitePlus   Signor 21209074
S177 Phosphorylation PhosphoSitePlus
S183 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T186 Phosphorylation PhosphoSitePlus
S192 Phosphorylation PhosphoSitePlus
S194 Phosphorylation PhosphoSitePlus
T200 Phosphorylation PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
T205 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 23186163, ...14657031
T205 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus 14657031
T205 Phosphorylation P53350 (PLK1) PhosphoSitePlus 14657031
T209 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14657031
T209 Phosphorylation P06493 (CDK1) PhosphoSitePlus 14657031
T209 Phosphorylation P53350 (PLK1) phospho.ELM   PhosphoSitePlus 14657031
S219 Phosphorylation PhosphoSitePlus
S220 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460, 18669648
S222 Phosphorylation phospho.ELM   PhosphoSitePlus 14657031, 22067460
S222 Phosphorylation P06493 (CDK1) PhosphoSitePlus 14657031
S241 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T244 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14657031
S252 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T264 Phosphorylation PhosphoSitePlus
S276 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T279 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T289 Phosphorylation phospho.ELM   PhosphoSitePlus 14657031
T289 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus 14657031
S291 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14657031
S296 Phosphorylation phospho.ELM   PhosphoSitePlus 14657031
T304 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S312 Phosphorylation phospho.ELM   PhosphoSitePlus 14657031, 22067460
S312 Phosphorylation P06493 (CDK1) PhosphoSitePlus 14657031
T313 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14657031, 22067460
K319 Ubiquitination PhosphoSitePlus
S320 Phosphorylation phospho.ELM 22067460
T329 Phosphorylation phospho.ELM   PhosphoSitePlus 14657031
T329 Phosphorylation P06493 (CDK1) PhosphoSitePlus 14657031
K330 Ubiquitination PhosphoSitePlus
S334 O-Glycosylation GlyGen 23301498, 35138101, 30379171, ...34725712, 31492838, 35132862, 32119511, 28510447
S334 Phosphorylation PhosphoSitePlus
S336 Phosphorylation PhosphoSitePlus
S339 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648
T343 Phosphorylation phospho.ELM   PhosphoSitePlus 14657031
T343 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus 14657031
T359 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S364 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460, 14657031
S364 Phosphorylation P06493 (CDK1) phospho.ELM 14657031
T366 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14657031, 18669648, 19690332, ...22067460
T368 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S369 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
S378 Phosphorylation PhosphoSitePlus
S379 Phosphorylation PhosphoSitePlus   Signor   UniProt 23186163, 22137581
S379 Phosphorylation P54646 (PRKAA2) PhosphoSitePlus   Signor 22137581
T383 Phosphorylation PhosphoSitePlus
S384 Phosphorylation phospho.ELM   PhosphoSitePlus 18669648
S386 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 20068231
S387 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T388 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
T389 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460, 18669648
K390 Ubiquitination PhosphoSitePlus
S393 Phosphorylation phospho.ELM   PhosphoSitePlus 22067460
K415 Ubiquitination PhosphoSitePlus
S426 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 14657031, 18669648, 23186163, ...22067460
S426 Phosphorylation P06493 (CDK1) PhosphoSitePlus   Signor 14657031
S426 Phosphorylation P53350 (PLK1) PhosphoSitePlus 14657031
T430 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14657031, 18669648
T430 Phosphorylation P06493 (CDK1) PhosphoSitePlus 14657031
T430 Phosphorylation P53350 (PLK1) phospho.ELM   PhosphoSitePlus 14657031
K431 Ubiquitination PhosphoSitePlus
S434 Phosphorylation phospho.ELM   PhosphoSitePlus 14657031, 18669648
S434 Phosphorylation P06493 (CDK1) PhosphoSitePlus 14657031
S434 Phosphorylation P53350 (PLK1) phospho.ELM   PhosphoSitePlus 14657031
S435 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 14657031, 18669648, 22067460
S435 Phosphorylation P06493 (CDK1) PhosphoSitePlus 14657031
S435 Phosphorylation P53350 (PLK1) PhosphoSitePlus 14657031
S438 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 22067460, 18669648, 16565220
K441 Ubiquitination PhosphoSitePlus
T444 Phosphorylation PhosphoSitePlus
T446 Phosphorylation phospho.ELM   PhosphoSitePlus   Signor   UniProt 14657031, 18669648, 23186163, ...22067460
T446 Phosphorylation P06493 (CDK1) phospho.ELM   PhosphoSitePlus   Signor 14657031
T446 Phosphorylation P53350 (PLK1) phospho.ELM   PhosphoSitePlus 14657031
S553 Phosphorylation PhosphoSitePlus
K557 Ubiquitination PhosphoSitePlus
K564 Ubiquitination PhosphoSitePlus
S578 Phosphorylation PhosphoSitePlus
K588 Ubiquitination PhosphoSitePlus
S685 O-Glycosylation GlyGen 23301498, 35138101, 30379171, ...34725712, 31492838, 35132862, 32119511, 28510447
K687 Ubiquitination PhosphoSitePlus
T691 O-Glycosylation GlyGen 23301498, 35138101, 30379171, ...34725712, 31492838, 35132862, 32119511, 28510447
T691 Phosphorylation PhosphoSitePlus
K694 Ubiquitination PhosphoSitePlus
K701 Ubiquitination PhosphoSitePlus
K706 Ubiquitination PhosphoSitePlus
K718 Ubiquitination PhosphoSitePlus
K720 Ubiquitination PhosphoSitePlus
K730 Ubiquitination PhosphoSitePlus
K735 Ubiquitination PhosphoSitePlus
Y740 Phosphorylation PhosphoSitePlus
K776 Ubiquitination PhosphoSitePlus
T809 Phosphorylation PhosphoSitePlus
S821 Phosphorylation PhosphoSitePlus   UniProt 22139841
Site PTM Type PTM Enzyme Score Source PMID
T205 Phosphorylation HPRD 18669648, 20068231
S220 Phosphorylation HPRD 18669648
S336 Phosphorylation HPRD 20068231
S339 Phosphorylation HPRD 18669648, 19007248, 19691289
S364 Phosphorylation HPRD 20068231
T366 Phosphorylation HPRD 18669648
S384 Phosphorylation HPRD 18669648, 20068231
S386 Phosphorylation HPRD 18669648, 20068231
S387 Phosphorylation HPRD 20068231
T388 Phosphorylation HPRD 20068231
T389 Phosphorylation HPRD 18669648, 20068231
S426 Phosphorylation HPRD 19413330, 18669648, 20068231
T430 Phosphorylation HPRD 18669648
S434 Phosphorylation HPRD 18669648, 20068231
S435 Phosphorylation HPRD 19691289, 16565220, 19651622, ...18669648, 19007248, 20068231
S438 Phosphorylation HPRD 19691289, 16565220, 19651622, ...18669648, 19007248, 20068231
T444 Phosphorylation HPRD 20068231
T446 Phosphorylation HPRD 19413330, 18669648, 20068231
T809 Phosphorylation HPRD 18452278
Site PTM Type PTM Enzyme Score Source PMID
T313 Phosphorylation PhosphoSitePlus
T320 Phosphorylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
T333 Phosphorylation PhosphoSitePlus
T335 Phosphorylation PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:000035449 (hCDC27/Phos:1) increased Interaction PR:O60566 (hBUB1B) PRO 11030144
PR:O60566 (hBUB1B) Interaction PR:000035449 (hCDC27/Phos:1) PRO 11030144
PR:O60566 (hBUB1B) Interaction PR:000035450 (hCDC27/PhosRes-) PRO 11030144


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K62 E62 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
C71 * Biomuta DOID:4159 / skin cancer [ cosmic, icgc ] DOID:1612 / breast cancer [ cosmic ]
C115 Y115 Biomuta DOID:3571 / liver cancer [ cosmic ]
C126 Y126 Biomuta DOID:4362 / cervical cancer [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
Y138 D138 Biomuta DOID:3565 / meningioma [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
S143 R143 Biomuta DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
S150 C150 Biomuta DOID:3565 / meningioma [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
S150 Y150 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S183 C183 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ]
S192 T192 Biomuta DOID:1324 / lung cancer [ cosmic ]
S194 C194 Biomuta DOID:4606 / bile duct cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ] DOID:5041 / esophageal cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ]
T203 M203 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
T203 K203 Biomuta DOID:4159 / skin cancer [ cosmic ]
T205 I205 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S220 A220 Biomuta DOID:4159 / skin cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ]
S252 T252 Biomuta DOID:10283 / prostate cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:2531 / hematologic cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:2394 / ovarian cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:1540 / parathyroid carcinoma [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ]
S252 F252 Biomuta [ cosmic ] DOID:4159 / skin cancer [ cosmic, icgc ]
T264 P264 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10534 / stomach cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
T289 A289 Biomuta DOID:3571 / liver cancer [ cosmic ]
T304 S304 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S312 P312 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S312 T312 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S312 C312 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
T313 I313 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
K319 N319 Biomuta DOID:1324 / lung cancer [ cosmic ]
S320 F320 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S320 P320 Biomuta DOID:3571 / liver cancer [ cosmic ]
S326 F326 Biomuta DOID:2394 / ovarian cancer [ cosmic, icgc ]
S326 P326 Biomuta DOID:3571 / liver cancer [ cosmic ]
T329 A329 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K330 T330 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ]
K330 Q330 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:1612 / breast cancer [ cosmic ]
T335 A335 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S336 R336 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S339 I339 Biomuta DOID:3953 / adrenal gland cancer [ cosmic ]
T368 A368 Biomuta DOID:1319 / brain cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ] DOID:4606 / bile duct cancer [ cosmic ]
S378 N378 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:10283 / prostate cancer [ cosmic ] DOID:3565 / meningioma [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
S379 L379 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
S384 G384 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S384 N384 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S387 Y387 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
T389 N389 Biomuta DOID:3571 / liver cancer [ cosmic ]
T389 A389 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
K390 E390 Biomuta DOID:3565 / meningioma [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
S393 R393 Biomuta DOID:3565 / meningioma [ cosmic ]
K415 Q415 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S426 G426 Biomuta DOID:1781 / thyroid cancer [ icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
S426 N426 Biomuta DOID:363 / uterine cancer [ icgc ]
S434 Y434 Biomuta DOID:1781 / thyroid gland cancer [ cosmic ] DOID:1781 / thyroid cancer [ icgc ]
S435 F435 Biomuta DOID:1781 / thyroid cancer [ icgc ] DOID:1781 / thyroid gland cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
K441 I441 Biomuta DOID:1324 / lung cancer [ cosmic ]
T444 A444 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
T446 A446 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S553 L553 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S578 G578 Biomuta DOID:3565 / meningioma [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
S578 T578 Biomuta DOID:263 / kidney cancer [ cosmic ]
K588 Q588 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:1781 / thyroid gland cancer [ cosmic ]
S685 L685 Biomuta DOID:4159 / skin cancer [ cosmic ]
T691 S691 Biomuta DOID:1793 / pancreatic cancer [ cosmic, icgc ]
K701 N701 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1319 / brain cancer [ cosmic, icgc ]