Protein Information

Cytoscape View


UniProt AC / UniProt ID P30153 / 2AAA_HUMAN
Protein Name Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform
Gene Name Name: PPP2R1A
Organism Homo sapiens (Human)

PRO ID PR:P30153
DAG View
PRO Name serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (human)
Definition A serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform that is encoded in the genome of human.
Short Label hPPP2R1A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30153 (PPP2R1A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
A2 Acetylation UniProt 19413330, 22814378, 22223895, ...25944712
S9 Phosphorylation HPRD   PhosphoSitePlus 18491316
K34 Ubiquitination PhosphoSitePlus
S36 Phosphorylation PhosphoSitePlus
T37 Phosphorylation PhosphoSitePlus
K107 Ubiquitination PhosphoSitePlus
S120 Phosphorylation PhosphoSitePlus
S122 Phosphorylation PhosphoSitePlus
K133 Ubiquitination PhosphoSitePlus
R134 Methylation PhosphoSitePlus
K163 Ubiquitination PhosphoSitePlus
R167 Methylation PhosphoSitePlus
K188 Acetylation PhosphoSitePlus
K188 Ubiquitination PhosphoSitePlus
K194 Ubiquitination PhosphoSitePlus
K202 Ubiquitination PhosphoSitePlus
K255 Ubiquitination PhosphoSitePlus
K266 Acetylation PhosphoSitePlus
K266 Ubiquitination PhosphoSitePlus
K272 Ubiquitination PhosphoSitePlus
K280 Acetylation PhosphoSitePlus   UniProt 19608861
K280 Ubiquitination PhosphoSitePlus
K292 Ubiquitination PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
K307 Ubiquitination PhosphoSitePlus
S335 Phosphorylation HPRD   PhosphoSitePlus 20068231
K342 Ubiquitination PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
S353 Phosphorylation PhosphoSitePlus
K374 Ubiquitination PhosphoSitePlus
C390 S-Nitrosylation dbSNO 19483679
K416 Ubiquitination PhosphoSitePlus
K442 Sumoylation PhosphoSitePlus
K467 Ubiquitination PhosphoSitePlus
K472 Ubiquitination PhosphoSitePlus
K475 Ubiquitination PhosphoSitePlus
K485 Ubiquitination PhosphoSitePlus
Y495 Phosphorylation PhosphoSitePlus
K519 Ubiquitination PhosphoSitePlus
R527 Methylation PhosphoSitePlus
K542 Ubiquitination PhosphoSitePlus
K546 Ubiquitination PhosphoSitePlus
S554 Phosphorylation PhosphoSitePlus
T555 O-Glycosylation GlyGen 23301498, 16408927, 26853435, ...29351928, 23576270, 32119511
K561 Acetylation PhosphoSitePlus
K561 Sumoylation PhosphoSitePlus
K561 Ubiquitination PhosphoSitePlus
K566 Ubiquitination PhosphoSitePlus
T584 Phosphorylation PhosphoSitePlus


Proteoform PPIs

Protein 1 Relation Protein 2 Source PMID
PR:Q5FBB7 (hSGO1) Interaction PR:P30153 (hPPP2R1A) PRO 16580887


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
A2 S2 Biomuta DOID:363 / uterine cancer [ tcga ]
S120 L120 Biomuta DOID:4362 / cervical cancer [ icgc, tcga ] DOID:1909 / melanoma [ tcga ]
R134 W134 Biomuta DOID:1909 / melanoma [ cosmic ]
R167 Q167 Biomuta DOID:3571 / liver cancer [ icgc, tcga ] DOID:0070003 / blastoma [ cosmic ]
K272 Q272 Biomuta DOID:263 / kidney cancer [ tcga ]
C390 F390 Biomuta DOID:3571 / liver cancer [ icgc ]
K546 T546 Biomuta DOID:9256 / colorectal cancer [ tcga ]
S554 I554 Biomuta DOID:363 / uterine cancer [ tcga ]