iPTMnet Report for P30101 (PDIA3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P30101 / PDIA3_HUMAN
Protein Name Protein disulfide-isomerase A3 precursor
Gene Name Name: PDIA3
Synonyms:ERP57,ERP60,GRP58;
Organism Homo sapiens (Human)

PRO ID PR:P30101
DAG View
PRO Name protein disulfide-isomerase A3 (human)
Definition A protein disulfide-isomerase A3 that is encoded in the genome of human.
Short Label hPDIA3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30101 (PDIA3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S37 Phosphorylation PhosphoSitePlus
K61 Methylation PhosphoSitePlus   UniProt 24129315
R62 Methylation PhosphoSitePlus
Y67 Phosphorylation PhosphoSitePlus
R73 Methylation PhosphoSitePlus
K75 Ubiquitination PhosphoSitePlus
K82 Ubiquitination PhosphoSitePlus
C85 S-Nitrosylation dbSNO 2212679, 22126794
T86 Phosphorylation PhosphoSitePlus
N90 N-Glycosylation GlyGen 23090970, 24190977
C92 S-Nitrosylation dbSNO 2212679, 22126794
K94 Acetylation PhosphoSitePlus
K94 Ubiquitination PhosphoSitePlus
Y95 Phosphorylation PhosphoSitePlus
S98 Phosphorylation PhosphoSitePlus
Y100 Phosphorylation PhosphoSitePlus
T102 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T102 Phosphorylation PhosphoSitePlus
K104 Acetylation PhosphoSitePlus
K104 Ubiquitination PhosphoSitePlus
Y115 Phosphorylation PhosphoSitePlus
R119 Methylation PhosphoSitePlus
T120 O-Glycosylation GlyGen 33214551, 30397120, 34725712, ...26853435, 30444036, 29351928, 34019948, 35083852, 31492838, 32119511, 28510447, 34229054
S126 O-Glycosylation GlyGen 33214551, 30397120, 34725712, ...26853435, 30444036, 29351928, 34019948, 35083852, 31492838, 32119511, 28510447, 34229054
S126 Phosphorylation HPRD   PhosphoSitePlus 20068231
K129 Acetylation PhosphoSitePlus
S136 Phosphorylation PhosphoSitePlus
R140 Methylation PhosphoSitePlus
T141 Phosphorylation PhosphoSitePlus
K146 Acetylation PhosphoSitePlus
S163 Phosphorylation PhosphoSitePlus
S165 Phosphorylation PhosphoSitePlus
K173 Ubiquitination PhosphoSitePlus
S176 Phosphorylation PhosphoSitePlus
R179 Methylation PhosphoSitePlus
Y196 Phosphorylation PhosphoSitePlus
K214 Acetylation PhosphoSitePlus
K214 Ubiquitination PhosphoSitePlus
T219 O-Glycosylation GlyGen 25813380
Y222 Phosphorylation PhosphoSitePlus
T223 Phosphorylation PhosphoSitePlus
K226 Acetylation PhosphoSitePlus
K226 Ubiquitination PhosphoSitePlus
K234 Acetylation PhosphoSitePlus
C244 S-Nitrosylation dbSNO 20140087
Y269 Phosphorylation PhosphoSitePlus
Y278 Phosphorylation PhosphoSitePlus
K289 Acetylation PhosphoSitePlus
K289 Ubiquitination PhosphoSitePlus
K296 Acetylation PhosphoSitePlus
K296 Ubiquitination PhosphoSitePlus
S303 Phosphorylation PhosphoSitePlus
K305 Ubiquitination PhosphoSitePlus
S312 Phosphorylation PhosphoSitePlus
S318 Phosphorylation PhosphoSitePlus
T319 Phosphorylation PhosphoSitePlus   UniProt 24275569
R329 Methylation PhosphoSitePlus
K335 Acetylation PhosphoSitePlus
K335 Ubiquitination PhosphoSitePlus
S343 Phosphorylation PhosphoSitePlus
Y356 Phosphorylation PhosphoSitePlus
K362 Acetylation PhosphoSitePlus
K362 Ubiquitination PhosphoSitePlus
K366 Ubiquitination PhosphoSitePlus
S367 Phosphorylation PhosphoSitePlus
S373 Phosphorylation PhosphoSitePlus
Y402 Phosphorylation PhosphoSitePlus
S424 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
K433 Ubiquitination PhosphoSitePlus
S443 Phosphorylation PhosphoSitePlus
Y445 Phosphorylation PhosphoSitePlus
R448 Methylation PhosphoSitePlus
T452 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
T452 Phosphorylation PhosphoSitePlus
Y454 Phosphorylation PhosphoSitePlus
S456 O-Glycosylation GlyGen   PhosphoSitePlus 23584533
S456 Phosphorylation PhosphoSitePlus 18234856
S456 Phosphorylation P06493 (CDK1) PhosphoSitePlus 18234856
K460 Acetylation PhosphoSitePlus
K466 Acetylation PhosphoSitePlus
S474 Phosphorylation PhosphoSitePlus
S478 Phosphorylation PhosphoSitePlus
Y479 Phosphorylation PhosphoSitePlus
T485 O-Glycosylation GlyGen   PhosphoSitePlus 33214551, 30397120, 34725712, ...26853435, 30444036, 29351928, 34019948, 35083852, 31492838, 23584533, 32119511, 28510447, 34229054, 29237092
T485 Phosphorylation IEDB 35494241


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R62 K62 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R73 I73 Biomuta DOID:363 / uterine cancer [ icgc ]
Y115 N115 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
Y115 F115 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
R179 S179 Biomuta DOID:4159 / skin cancer [ cosmic, icgc ]
T219 I219 Biomuta DOID:363 / uterine cancer [ icgc ]
Y222 H222 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc ]
S312 F312 Biomuta DOID:4159 / skin cancer [ cosmic ]
S343 * Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S343 L343 Biomuta DOID:9256 / colorectal cancer [ cosmic ]