iPTMnet Report for P30084 (ECHS1)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P30084 / ECHM_HUMAN
Protein Name Enoyl-CoA hydratase, mitochondrial precursor
Gene Name Name: ECHS1
Organism Homo sapiens (Human)

PRO ID PR:P30084
DAG View
PRO Name enoyl-CoA hydratase, mitochondrial (human)
Definition An enoyl-CoA hydratase, mitochondrial that is encoded in the genome of human.
Short Label hECHS1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30084 (ECHS1) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S9 O-Glycosylation GlyGen 34725712, 33465208, 34229054
Y35 Phosphorylation PhosphoSitePlus
K40 Acetylation PhosphoSitePlus
T46 Phosphorylation PhosphoSitePlus   UniProt 24275569
K56 Ubiquitination PhosphoSitePlus
C62 S-Nitrosylation dbSNO 25040305
K92 Acetylation PhosphoSitePlus
K92 Ubiquitination PhosphoSitePlus
K101 Acetylation PhosphoSitePlus
S107 Phosphorylation PhosphoSitePlus
S114 Phosphorylation PhosphoSitePlus   UniProt 24275569
K115 Acetylation PhosphoSitePlus
K115 Ubiquitination PhosphoSitePlus
K118 Acetylation PhosphoSitePlus   UniProt 19608861
K118 Ubiquitination PhosphoSitePlus
Y137 Phosphorylation PhosphoSitePlus
C143 Methylation IEDB 31844290
T176 Phosphorylation PhosphoSitePlus
S186 Phosphorylation HPRD   PhosphoSitePlus 20068231
T194 Phosphorylation PhosphoSitePlus
R197 Methylation PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
K204 Acetylation PhosphoSitePlus
K204 Ubiquitination PhosphoSitePlus
K211 Ubiquitination PhosphoSitePlus
C213 S-Nitrosylation dbSNO 26338901, 22178444
C225 S-Nitrosylation dbSNO 26338901, 22178444
T251 Phosphorylation HPRD 20068231
K261 Acetylation PhosphoSitePlus
K261 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S107 G107 Biomuta DOID:10534 / stomach cancer [ cosmic ]
S186 L186 Biomuta DOID:363 / uterine cancer [ icgc ] DOID:9256 / colorectal cancer [ cosmic ]
R197 W197 Biomuta DOID:10283 / prostate cancer [ cosmic, icgc ]