iPTMnet Report for P30048 (PRDX3)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P30048 / PRDX3_HUMAN
Protein Name Thioredoxin-dependent peroxide reductase, mitochondrial precursor
Gene Name Name: PRDX3
Synonyms:AOP1;
Organism Homo sapiens (Human)

PRO ID PR:P30048
DAG View
PRO Name thioredoxin-dependent peroxide reductase, mitochondrial (human)
Definition A thioredoxin-dependent peroxide reductase, mitochondrial that is encoded in the genome of human.
Short Label hPRDX3
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30048 (PRDX3) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
C35 Methylation IEDB 31844290
Y71 Phosphorylation PhosphoSitePlus
K83 Acetylation PhosphoSitePlus
K83 Ubiquitination PhosphoSitePlus
S86 Phosphorylation PhosphoSitePlus
K91 Acetylation PhosphoSitePlus   UniProt 19608861
K91 Ubiquitination PhosphoSitePlus
K93 Acetylation PhosphoSitePlus
C108 Methylation IEDB 31844290
C127 Methylation IEDB 31844290
T146 Phosphorylation neXtProt   Signor   UniProt 21850687
T146 Phosphorylation Q5S007 (LRRK2) neXtProt   Signor 21850687
K149 Ubiquitination PhosphoSitePlus
Y172 Phosphorylation PhosphoSitePlus
S179 Phosphorylation PhosphoSitePlus
K196 Acetylation PhosphoSitePlus
K196 Sumoylation PhosphoSitePlus
K196 Ubiquitination PhosphoSitePlus
S199 Phosphorylation PhosphoSitePlus
R207 Methylation PhosphoSitePlus
T212 Phosphorylation PhosphoSitePlus
R214 Methylation PhosphoSitePlus
C229 S-Nitrosylation dbSNO 22178444, 19366988, 18335467
T234 Phosphorylation PhosphoSitePlus
S237 Phosphorylation PhosphoSitePlus
K241 Ubiquitination PhosphoSitePlus
K248 Acetylation PhosphoSitePlus
K253 Acetylation PhosphoSitePlus
K253 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y71 C71 Biomuta DOID:1793 / pancreatic cancer [ cosmic ]
C108 R108 Biomuta DOID:3571 / liver cancer [ cosmic ]
R214 C214 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
R214 H214 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S237 F237 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S237 C237 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc ]