iPTMnet Report for P30041 (PRDX6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P30041 / PRDX6_HUMAN
Protein Name Peroxiredoxin-6
Gene Name Name: PRDX6
Synonyms:AOP2,KIAA0106;
Organism Homo sapiens (Human)

PRO ID PR:P30041
DAG View
PRO Name peroxiredoxin-6 (human)
Definition A peroxiredoxin-6 that is encoded in the genome of human.
Short Label hPRDX6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P30041 (PRDX6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S32 Phosphorylation PhosphoSitePlus
T44 Phosphorylation HPRD   PhosphoSitePlus   UniProt 23186163, 18767875, 19664994, ...17322306, 18669648, 20068231
C47 S-Nitrosylation dbSNO 25040305, 2212679, 22126794
K56 Acetylation PhosphoSitePlus
K56 Sumoylation PhosphoSitePlus
K56 Ubiquitination PhosphoSitePlus
K63 Acetylation PhosphoSitePlus   UniProt 19608861
K63 Methylation PhosphoSitePlus
K63 Sumoylation PhosphoSitePlus
K63 Ubiquitination PhosphoSitePlus
S83 Phosphorylation PhosphoSitePlus
K84 Ubiquitination PhosphoSitePlus
Y89 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 15592455
C91 S-Nitrosylation dbSNO 19483679
K97 Acetylation PhosphoSitePlus
K97 Ubiquitination PhosphoSitePlus
R106 Methylation PhosphoSitePlus
R108 Methylation PhosphoSitePlus
K122 Acetylation PhosphoSitePlus
K122 Sumoylation PhosphoSitePlus
K122 Ubiquitination PhosphoSitePlus
K125 Sumoylation PhosphoSitePlus
K125 Ubiquitination PhosphoSitePlus
T130 Phosphorylation PhosphoSitePlus
K141 Acetylation PhosphoSitePlus
K141 Ubiquitination PhosphoSitePlus
K142 Acetylation PhosphoSitePlus
K142 Sumoylation PhosphoSitePlus
K144 Acetylation PhosphoSitePlus
S146 Phosphorylation PhosphoSitePlus
R155 Methylation PhosphoSitePlus
S166 Phosphorylation HPRD 20068231
T177 Phosphorylation HPRD   PhosphoSitePlus   RLIMS-P   Signor 19140803, 19664994, 20919932, ...28055018
T177 Phosphorylation P28482 (MAPK1) PhosphoSitePlus   Signor 19140803
K182 Acetylation PhosphoSitePlus
K182 Methylation PhosphoSitePlus
K182 Sumoylation PhosphoSitePlus
K182 Ubiquitination PhosphoSitePlus
S186 Phosphorylation HPRD   PhosphoSitePlus 20068231
K199 Sumoylation PhosphoSitePlus
K199 Ubiquitination PhosphoSitePlus
K200 Ubiquitination PhosphoSitePlus
K204 Sumoylation PhosphoSitePlus
K209 Acetylation PhosphoSitePlus   UniProt 19608861
K209 Sumoylation PhosphoSitePlus
K209 Ubiquitination PhosphoSitePlus
K215 Acetylation PhosphoSitePlus
K216 Acetylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
R106 M106 Biomuta DOID:1324 / lung cancer [ cosmic ]
R106 G106 Biomuta DOID:263 / kidney cancer [ cosmic, icgc ]
R108 W108 Biomuta DOID:9256 / colorectal cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic, icgc ]
R108 Q108 Biomuta DOID:1319 / brain cancer [ cosmic, icgc ] DOID:10534 / stomach cancer [ cosmic, icgc ] DOID:11054 / urinary bladder cancer [ cosmic ]
K200 Q200 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K215 N215 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K215 R215 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]