Protein Information

Cytoscape View

UniProt AC / UniProt ID P30038 / AL4A1_HUMAN
Protein Name Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor
Gene Name Name: ALDH4A1
Organism Homo sapiens (Human)

PRO ID PR:P30038
DAG View
PRO Name delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (human)
Definition A delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial that is encoded in the genome of human.
Short Label hALDH4A1
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P30038 (ALDH4A1) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
S44 Phosphorylation PhosphoSitePlus   UniProt 23186163, 24275569
K93 Acetylation PhosphoSitePlus
Y96 Phosphorylation PhosphoSitePlus
K153 Methylation PhosphoSitePlus
R304 Methylation PhosphoSitePlus
S326 Phosphorylation PhosphoSitePlus
S331 Phosphorylation PhosphoSitePlus
T336 Phosphorylation PhosphoSitePlus
K402 Acetylation PhosphoSitePlus
K462 Acetylation PhosphoSitePlus
K495 Methylation PhosphoSitePlus
K495 Ubiquitination PhosphoSitePlus
R498 Methylation PhosphoSitePlus
Y505 Phosphorylation phospho.ELM   PhosphoSitePlus 18083107
T528 Phosphorylation PhosphoSitePlus
K552 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y505 Phosphorylation HPRD 18083107

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
Y96 F96 Biomuta DOID:2531 / hematologic cancer [ icgc ]
Y96 H96 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
Y96 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K153 E153 Biomuta DOID:363 / uterine cancer [ tcga ]
S326 L326 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
K462 N462 Biomuta DOID:1324 / lung cancer [ cosmic ]
R498 K498 Biomuta DOID:5041 / esophageal cancer [ icgc ]