Protein Information

Cytoscape View


UniProt AC / UniProt ID P29966 / MARCS_HUMAN
Protein Name Myristoylated alanine-rich C-kinase substrate
Gene Name Name: MARCKS
Synonyms:MACS,PRKCSL;
Organism Homo sapiens (Human)

PRO ID PR:P29966
DAG View
PRO Name myristoylated alanine-rich C-kinase substrate (human)
Definition A myristoylated alanine-rich C-kinase substrate that is encoded in the genome of human.
Short Label hMARCKS
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P29966 (MARCKS) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
G2 Myristoylation UniProt 25255805
K11 Ubiquitination PhosphoSitePlus
S26 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18578522, 18491316, ...17287340, 17081983, 18847512, 19664995, 18452278, 18669648, 24275569, 20068231
S27 Phosphorylation P17252 (PRKCA) , P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18578522, 18491316, ...17287340, 17081983, 18767875, 18847512, 19664995, 18452278, 19651622, 17322306, 18669648, 23186163, 20068231, 17924679
S29 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18578522, 18491316, ...17287340, 17081983, 19651622, 18669648, 24275569, 20068231
K30 Ubiquitination PhosphoSitePlus
S46 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 21406692, 27557632, ...17081983, 30225354, 19664994, 19651622, 18669648, 18510355, 8034575, 20068231
S52 Phosphorylation PhosphoSitePlus
K55 Ubiquitination PhosphoSitePlus
S63 Phosphorylation HPRD   PhosphoSitePlus   UniProt 19413330, 21406692
K69 Ubiquitination PhosphoSitePlus
S77 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 17081983, ...18452278, 19651622, 18669648, 20068231
S81 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 21406692, 19664994, ...18452278, 19651622, 18669648, 8034575, 20068231
S83 Phosphorylation HPRD   PhosphoSitePlus 19413330
K87 Ubiquitination PhosphoSitePlus
S101 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17322306, 18578522, ...23186163, 17081983, 18767875, 19664994, 19664995, 18452278, 19651622, 18669648, 21406692, 24275569, 18707149, 18510355, 20068231
K105 Ubiquitination PhosphoSitePlus
S118 Phosphorylation P17252 (PRKCA) , P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18847512, 19664995, ...18452278, 18669648, 18707149, 20166139, 8034575, 20068231
T120 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 19413330, 18578522, 18452278, ...18669648, 20068231
S128 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 17081983, 18452278
S131 Phosphorylation P24941 (CDK2) HPRD   PhosphoSitePlus 19413330, 18847512, 18452278
S132 Phosphorylation P24941 (CDK2) HPRD   PhosphoSitePlus 19413330, 18847512, 18452278
T133 Phosphorylation P24941 (CDK2) PhosphoSitePlus 18847512
S134 Phosphorylation P24941 (CDK2) HPRD   PhosphoSitePlus 19413330, 18847512
S135 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18847512, 18452278, ...24275569, 15345747, 20068231
T143 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 19651622, 18669648, ...17081983
S145 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18578522, 17287340, ...17081983, 19664994, 19664995, 19651622, 17322306, 18669648, 24275569, 20068231, 18212344
S147 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 18578522, 17081983, ...18847512, 19664995, 19651622, 18669648, 24275569, 18707149, 20068231
T150 Phosphorylation P24941 (CDK2) HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19413330, 17322306, 21406692, ...17287340, 17081983, 18767875, 18847512, 19664994, 18578522, 19664995, 19651622, 18669648, 20166139, 23186163, 20068231, 18212344
K152 Ubiquitination PhosphoSitePlus
K153 Ubiquitination PhosphoSitePlus
S159 Phosphorylation Q13464 (ROCK1) , P17252 (PRKCA) , P05771 (PRKCB) , P17612 (PRKACA) , Q16512 (PKN1) HPRD   neXtProt   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 15708490, 18767875, 32033033, ...11162562, 17081983, 33477989, 16116087, 14727513, 11930178, 21448919, 14501149, 1650359, 8557118, 33754052, 16677610, 20068231
K161 Methylation PhosphoSitePlus
S163 Phosphorylation P17252 (PRKCA) , P05771 (PRKCB) , Q16512 (PKN1) HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 21406692, 32033033, 17287340, ...17081983, 7588787, 16116087, 11930178, 18669648, 1650359, 8557118, 33754052, 33477989, 20068231
K165 Acetylation PhosphoSitePlus
K165 Ubiquitination PhosphoSitePlus
S167 Phosphorylation P17252 (PRKCA) HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 19413330, 32033033, 17287340, ...17081983, 18767875, 19651622, 18669648, 2473066, 1650359, 18212344, 20068231, 17924679
S170 Phosphorylation P17252 (PRKCA) , Q16512 (PKN1) , P05771 (PRKCB) HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   UniProt 18578522, 18707149, 21406692, ...23186163, 18212344, 24275569, 19413330, 32033033, 18767875, 20058876, 19651622, 8557118, 17287340, 17081983, 19664995, 17322306, 18669648, 1650359, 20166139, 33477989, 20068231
K172 Acetylation PhosphoSitePlus
K172 Methylation PhosphoSitePlus
K176 Ubiquitination PhosphoSitePlus
K248 Methylation PhosphoSitePlus
S252 Phosphorylation PhosphoSitePlus
S262 Phosphorylation HPRD   PhosphoSitePlus 15345747
K267 Ubiquitination PhosphoSitePlus
S314 Phosphorylation PhosphoSitePlus   UniProt 24275569


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000048337 (hMARCKS/InitMet-/Phos:1) pS159,pS163,pS167,pS170 PRO


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S29 F29 Biomuta DOID:1909 / melanoma [ icgc, tcga ]
S118 L118 Biomuta DOID:9256 / colorectal cancer [ icgc ]
T120 M120 Biomuta DOID:1612 / breast cancer [ cosmic ]
S131 A131 Biomuta DOID:1909 / melanoma [ cosmic ]
S132 L132 Biomuta DOID:4362 / cervical cancer [ cosmic, icgc ]
S167 C167 Biomuta DOID:1324 / lung cancer [ cosmic, icgc, tcga ]
S314 L314 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]