iPTMnet Report for P29803 (PDHA2)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P29803 / ODPAT_HUMAN
Protein Name Pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial precursor
Gene Name Name: PDHA2
Synonyms:PDHAL;
Organism Homo sapiens (Human)

PRO ID PR:P29803
DAG View
PRO Name pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial (human)
Definition A pyruvate dehydrogenase E1 component subunit alpha, testis-specific form, mitochondrial that is encoded in the genome of human.
Short Label hPDHA2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P29803 (PDHA2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K16 Sumoylation PhosphoSitePlus
S17 Phosphorylation IEDB 35494241
K37 Acetylation PhosphoSitePlus
Y42 Phosphorylation PhosphoSitePlus
Y62 Phosphorylation PhosphoSitePlus
Y63 Phosphorylation PhosphoSitePlus
K75 Acetylation PhosphoSitePlus
K81 Acetylation PhosphoSitePlus
K81 Ubiquitination PhosphoSitePlus
S150 Phosphorylation PhosphoSitePlus
Y154 Phosphorylation PhosphoSitePlus
S230 Phosphorylation PhosphoSitePlus 16436377
S230 Phosphorylation Q15118 (PDK1) PhosphoSitePlus 16436377
K275 Acetylation PhosphoSitePlus
Y287 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107, 20068231
S291 Phosphorylation HPRD   neXtProt   phospho.ELM   PhosphoSitePlus   Signor   UniProt 19413330, 18088087, 17081983, ...18220336, 19651622, 31536960, 18669648, 14966024, 20068231, 16436377
S291 Phosphorylation Q15118 (PDK1) neXtProt   PhosphoSitePlus   Signor 16436377
S291 Phosphorylation Q15119 (PDK2) neXtProt   PhosphoSitePlus   Signor 16436377
S291 Phosphorylation Q15120 (PDK3) neXtProt   PhosphoSitePlus   Signor 16436377
S291 Phosphorylation Q16654 (PDK4) neXtProt   PhosphoSitePlus   Signor 14966024, 16436377
S293 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18220336, 19651622, ...31536960, 18669648, 20068231
S298 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18220336, 19651622, ...18669648, 20068231, 16436377
S298 Phosphorylation Q15118 (PDK1) PhosphoSitePlus 16436377
S298 Phosphorylation Q15119 (PDK2) PhosphoSitePlus 16436377
S298 Phosphorylation Q15120 (PDK3) PhosphoSitePlus 16436377
S298 Phosphorylation Q16654 (PDK4) PhosphoSitePlus 16436377
Y299 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus 18083107, 20068231, 18220336
T301 Phosphorylation PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K16 N16 Biomuta [ cosmic ]
S17 * Biomuta DOID:1324 / lung cancer [ cosmic ]
S17 T17 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K37 M37 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y42 N42 Biomuta DOID:4606 / bile duct cancer [ cosmic ]
Y63 * Biomuta DOID:1324 / lung cancer [ cosmic ]
K75 R75 Biomuta DOID:3571 / liver cancer [ cosmic ]
K75 T75 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K75 N75 Biomuta DOID:5041 / esophageal cancer [ cosmic, icgc ]
S150 L150 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
Y154 H154 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K275 T275 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K275 R275 Biomuta DOID:2531 / hematologic cancer [ cosmic, icgc ]
S293 T293 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
S298 C298 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]