Protein Information

Cytoscape View

UniProt AC / UniProt ID P29597 / TYK2_HUMAN
Protein Name Non-receptor tyrosine-protein kinase TYK2
Gene Name Name: TYK2
Organism Homo sapiens (Human)

PRO ID PR:P29597
DAG View
PRO Name non-receptor tyrosine-protein kinase TYK2 (human)
Definition A non-receptor tyrosine-protein kinase TYK2 that is encoded in the genome of human.
Short Label hTYK2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species

P29597 (TYK2) as Substrate

Site PTM Type PTM Enzyme Score Source PMID
T67 Phosphorylation PhosphoSitePlus
Y292 Phosphorylation HPRD   phospho.ELM   PhosphoSitePlus   UniProt 19901323, 18691976, 15659558, ...19369195, 18083107, 23186163
S339 Phosphorylation PhosphoSitePlus
S340 Phosphorylation PhosphoSitePlus
K354 Ubiquitination PhosphoSitePlus
K389 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
S406 Phosphorylation PhosphoSitePlus
S415 Phosphorylation PhosphoSitePlus
Y423 Phosphorylation PhosphoSitePlus
Y433 Phosphorylation PhosphoSitePlus
S491 Phosphorylation PhosphoSitePlus
S499 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 23186163
K504 Ubiquitination PhosphoSitePlus
S577 Phosphorylation PhosphoSitePlus
S580 Phosphorylation PhosphoSitePlus
K587 Ubiquitination PhosphoSitePlus
Y604 Phosphorylation PhosphoSitePlus
S613 Phosphorylation PhosphoSitePlus
S720 Phosphorylation PhosphoSitePlus
S723 Phosphorylation PhosphoSitePlus
K728 Ubiquitination PhosphoSitePlus
K756 Ubiquitination PhosphoSitePlus
K823 Ubiquitination PhosphoSitePlus
Y827 Phosphorylation PhosphoSitePlus
Y851 Phosphorylation PhosphoSitePlus
S884 Phosphorylation HPRD   PhosphoSitePlus   UniProt 18691976, 19369195
K899 Ubiquitination PhosphoSitePlus
K930 Ubiquitination PhosphoSitePlus
K933 Ubiquitination PhosphoSitePlus
K945 Ubiquitination PhosphoSitePlus
K963 Ubiquitination PhosphoSitePlus
K1046 Ubiquitination PhosphoSitePlus
Y1054 Phosphorylation P29597 (TYK2) , P23458 (JAK1) HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor   UniProt 19901323, 20478313, 15659558, ...28687744, 21625597, 8702790, 30029643
Y1055 Phosphorylation P29597 (TYK2) , P23458 (JAK1) HPRD   phospho.ELM   PRO   PhosphoSitePlus   RLIMS-P   Signor 19901323, 15659558, 28687744, ...21625597, 8702790
K1074 Ubiquitination PhosphoSitePlus
K1175 Ubiquitination PhosphoSitePlus

P29597 (TYK2) as PTM Enzyme

Substrate Site Score Source PMID
O15304 (SIVA1) Y53 PhosphoSitePlus 20727854
O15304 (SIVA1) Y162 PhosphoSitePlus 20727854
P17181 (IFNAR1) Y466 HPRD   phospho.ELM   PhosphoSitePlus 9677371, 8605876, 8700538
P17181 (IFNAR1) Y481 HPRD   phospho.ELM   PhosphoSitePlus   Signor 7526154, 8605876, 95059042
P29597 (TYK2) Y1054 phospho.ELM   PhosphoSitePlus   Signor   UniProt 20478313, 8702790
P29597 (TYK2) Y1055 phospho.ELM   PhosphoSitePlus   Signor 8702790
P42224-2 (STAT1) Y701 HPRD 10918587, 7657660, 15322115, ...7543024, 11839738, 12817007, 7690989, 11294897, 12637327
P51452 (DUSP3) Y138 Signor 17785772
P63244 (RACK1) Y194 phospho.ELM   PhosphoSitePlus 15240704
Q13651 (IL10RA) Y446 phospho.ELM 10433356
Q13651 (IL10RA) Y496 phospho.ELM 10433356
Q9BZL6 (PRKD2) Y438 neXtProt 21865166


PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000049570 (hTYK2/Phos:1) pY1054 PRO
PR:000049571 (hTYK2/Phos:2) pY1054,pY1055 PRO

PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S491 C491 Biomuta DOID:263 / kidney cancer [ tcga ]
K504 R504 Biomuta DOID:5041 / esophageal cancer [ tcga ]
K728 R728 Biomuta DOID:1324 / lung cancer [ cosmic ]
K728 N728 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
Y827 * Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
Y1054 H1054 Biomuta DOID:2394 / ovarian cancer [ icgc ] DOID:2994 / germ cell cancer [ cosmic ]
Y1054 * Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]