iPTMnet Report for P29375 (KDM5A)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P29375 / KDM5A_HUMAN
Protein Name Lysine-specific demethylase 5A
Gene Name Name: KDM5A
Synonyms:JARID1A,RBBP2,RBP2;
Organism Homo sapiens (Human)

PRO ID PR:P29375
DAG View
PRO Name lysine-specific demethylase 5A (human)
Definition A lysine-specific demethylase 5A that is encoded in the genome of human.
Short Label hKDM5A
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P29375 (KDM5A) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K45 Ubiquitination PhosphoSitePlus
T46 Phosphorylation PhosphoSitePlus
C49 Methylation IEDB 31844290
K50 Ubiquitination PhosphoSitePlus
K106 Ubiquitination PhosphoSitePlus
K113 Ubiquitination PhosphoSitePlus
K127 Ubiquitination PhosphoSitePlus
T134 Phosphorylation PhosphoSitePlus
K135 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K159 Ubiquitination PhosphoSitePlus
S160 Phosphorylation PhosphoSitePlus
Y162 Phosphorylation PhosphoSitePlus
K191 Sumoylation PhosphoSitePlus
K191 Ubiquitination PhosphoSitePlus
T203 Phosphorylation PhosphoSitePlus
S204 Phosphorylation PhosphoSitePlus   UniProt 23186163
K222 Sumoylation PhosphoSitePlus
K222 Ubiquitination PhosphoSitePlus
S225 Phosphorylation PhosphoSitePlus
K238 Ubiquitination PhosphoSitePlus
K247 Ubiquitination PhosphoSitePlus
T285 Phosphorylation PhosphoSitePlus
S287 Phosphorylation PhosphoSitePlus
K339 Ubiquitination PhosphoSitePlus
K347 Ubiquitination PhosphoSitePlus
K392 Ubiquitination PhosphoSitePlus
S399 Phosphorylation PhosphoSitePlus
K425 Ubiquitination PhosphoSitePlus
C587 Methylation IEDB 31844290
K733 Ubiquitination PhosphoSitePlus
K757 Ubiquitination PhosphoSitePlus
K774 Ubiquitination PhosphoSitePlus
K789 Ubiquitination PhosphoSitePlus
K804 Ubiquitination PhosphoSitePlus
K820 Ubiquitination PhosphoSitePlus
K847 Ubiquitination PhosphoSitePlus
K895 Sumoylation PhosphoSitePlus
K895 Ubiquitination PhosphoSitePlus
T918 Phosphorylation PhosphoSitePlus
K924 Acetylation PhosphoSitePlus
K924 Ubiquitination PhosphoSitePlus
K960 Ubiquitination PhosphoSitePlus
S970 Phosphorylation PhosphoSitePlus
S973 Phosphorylation PhosphoSitePlus
K982 Ubiquitination PhosphoSitePlus
K995 Ubiquitination PhosphoSitePlus
K1007 Ubiquitination PhosphoSitePlus
K1029 Ubiquitination PhosphoSitePlus
S1066 Phosphorylation PhosphoSitePlus
T1069 Phosphorylation PhosphoSitePlus
S1075 Phosphorylation PhosphoSitePlus
K1087 Ubiquitination PhosphoSitePlus
K1094 Ubiquitination PhosphoSitePlus
K1103 Ubiquitination PhosphoSitePlus
S1111 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 17081983, 18669648, 24275569, ...19690332, 20068231
K1136 Ubiquitination PhosphoSitePlus
S1143 Phosphorylation PhosphoSitePlus
K1151 Ubiquitination PhosphoSitePlus
K1206 Ubiquitination PhosphoSitePlus
K1209 Ubiquitination PhosphoSitePlus
T1225 Phosphorylation PhosphoSitePlus
S1255 Phosphorylation PhosphoSitePlus
K1275 Ubiquitination PhosphoSitePlus
S1280 Phosphorylation PhosphoSitePlus
K1294 Ubiquitination PhosphoSitePlus
K1302 Ubiquitination PhosphoSitePlus
S1326 Phosphorylation IEDB 28228285
S1327 Phosphorylation IEDB   PhosphoSitePlus 28228285
S1329 Phosphorylation IEDB   PhosphoSitePlus 28228285
S1330 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 23186163
S1331 Phosphorylation phospho.ELM   PhosphoSitePlus   UniProt 18669648, 15302935
T1343 Phosphorylation PhosphoSitePlus
S1345 Phosphorylation PhosphoSitePlus
K1364 Ubiquitination PhosphoSitePlus
S1365 Phosphorylation PhosphoSitePlus
K1382 Sumoylation PhosphoSitePlus
S1410 Phosphorylation PhosphoSitePlus
S1414 Phosphorylation PhosphoSitePlus
T1415 Phosphorylation PhosphoSitePlus
S1423 Phosphorylation PhosphoSitePlus
S1438 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1488 Phosphorylation PhosphoSitePlus   UniProt 23186163
K1539 Ubiquitination PhosphoSitePlus
S1579 Phosphorylation PhosphoSitePlus
S1598 Phosphorylation PhosphoSitePlus   UniProt 17081983
S1603 Phosphorylation PhosphoSitePlus   UniProt 17081983
S1666 Phosphorylation PhosphoSitePlus   UniProt 23186163
S1674 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T46 Phosphorylation HPRD 20068231
S1111 Phosphorylation HPRD 19651622, 18669648, 17081983, ...20068231, 18452278
S1329 Phosphorylation HPRD 19691289
S1330 Phosphorylation HPRD 18669648
S1331 Phosphorylation HPRD 18669648, 19691289, 20068231
T1343 Phosphorylation HPRD 18452278
S1345 Phosphorylation HPRD 18452278
S1423 Phosphorylation HPRD 19691289, 20068231
S1488 Phosphorylation HPRD 18452278
S1598 Phosphorylation HPRD 17081983
S1603 Phosphorylation HPRD 17081983


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K113 Q113 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
K113 N113 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S160 L160 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]
K191 T191 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S225 * Biomuta DOID:4362 / cervical cancer [ cosmic ]
K238 T238 Biomuta DOID:363 / uterine cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ]
K789 N789 Biomuta DOID:9256 / colorectal cancer [ cosmic ]
S970 I970 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:1324 / lung cancer [ cosmic ]
S970 C970 Biomuta DOID:10534 / stomach cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ]
K982 N982 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ] DOID:9256 / colorectal cancer [ cosmic ]
K1007 N1007 Biomuta DOID:363 / uterine cancer [ cosmic ]
S1066 F1066 Biomuta DOID:1612 / breast cancer [ cosmic ]
S1066 C1066 Biomuta [ cosmic ]
K1094 Q1094 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
K1094 * Biomuta [ cosmic ]
K1206 * Biomuta DOID:10283 / prostate cancer [ cosmic ]
T1225 I1225 Biomuta DOID:8618 / oral cavity cancer [ cosmic ] DOID:11934 / head and neck cancer [ icgc ]
S1327 N1327 Biomuta DOID:363 / uterine cancer [ icgc ]
S1329 * Biomuta DOID:363 / uterine cancer [ cosmic ]
S1331 P1331 Biomuta DOID:1324 / lung cancer [ cosmic ]
T1343 A1343 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1410 F1410 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1414 N1414 Biomuta DOID:4159 / skin cancer [ cosmic ]
S1414 G1414 Biomuta DOID:1324 / lung cancer [ cosmic ]
S1423 C1423 Biomuta DOID:10283 / prostate cancer [ cosmic ]
S1423 N1423 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1488 I1488 Biomuta DOID:363 / uterine cancer [ cosmic, icgc ]
S1598 L1598 Biomuta [ cosmic ]
S1598 A1598 Biomuta DOID:5041 / esophageal cancer [ cosmic ]
S1603 C1603 Biomuta DOID:1324 / lung cancer [ cosmic, icgc ]