iPTMnet Report P29350 PTPN6

Protein Information

UniProt AC / UniProt ID	P29350 / PTN6_HUMAN
Protein Name	Tyrosine-protein phosphatase non-receptor type 6
Gene Name	Name: PTPN6 Synonyms:HCP,PTP1C;
Organism	Homo sapiens (Human)

PRO ID	PR:P29350 DAG View
PRO Name	tyrosine-protein phosphatase non-receptor type 6 (human)
Definition	A tyrosine-protein phosphatase non-receptor type 6 that is encoded in the genome of human.
Short Label	hPTPN6
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P29350 (PTPN6) as Substrate

Expanded View

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S10 K19 S26 K34 S57 Y61 Y64 K97 Y98 Y111 S140 S151 K155 K168 Y176 T177 S186 T188 K195 K196 Y208 Y213 Y214 K232 K241 S250 K253 K257 K271 Y276 K277 S285 R286 S299 Y301 Y306 K308 T350 K360 Y364 Y374 Y377 S378 K391 T394 S398 C453 K486 S496 Y509 K521 K522 S528 K530 S534 Y536 T540 Y541 K546 S553 T555 S556 S557 K560 Y564 K570 S582 S588 S591	PTM Type Select all Acetylation Methylation O-Glycosylation Phosphorylation S-Nitrosylation Ubiquitination	PTM Enzyme	Score Select all 0 1 2 3 4	Source Select all GlyGen IEDB IntAct PhosphoSitePlus RLIMS-P Signor UniProt dbSNO neXtProt phospho.ELM	PMID
S10	Phosphorylation		score1	PhosphoSitePlus
K19	Ubiquitination		score1	PhosphoSitePlus
S26	Phosphorylation		score2	IEDB PhosphoSitePlus	35494241
K34	Ubiquitination		score1	PhosphoSitePlus
S57	Phosphorylation		score1	PhosphoSitePlus
Y61	Phosphorylation		score1	PhosphoSitePlus
Y64	Phosphorylation		score2	PhosphoSitePlus UniProt	19690332
K97	Ubiquitination		score1	PhosphoSitePlus
Y98	Phosphorylation		score1	PhosphoSitePlus
Y111	Phosphorylation		score1	PhosphoSitePlus
S140	Phosphorylation		score1	PhosphoSitePlus
S151	O-Glycosylation		score1	GlyGen	30379171, 29351928
K155	Ubiquitination		score1	PhosphoSitePlus
K168	Ubiquitination		score1	PhosphoSitePlus
Y176	Phosphorylation		score1	PhosphoSitePlus
T177	Phosphorylation		score1	PhosphoSitePlus
S186	Phosphorylation		score1	PhosphoSitePlus
T188	Phosphorylation		score1	PhosphoSitePlus
K195	Ubiquitination		score1	PhosphoSitePlus
K196	Ubiquitination		score1	PhosphoSitePlus
Y208	Phosphorylation		score0	RLIMS-P	18617527
Y213	Phosphorylation		score1	PhosphoSitePlus
Y214	Phosphorylation		score1	PhosphoSitePlus
K232	Ubiquitination		score1	PhosphoSitePlus
K241	Ubiquitination		score1	PhosphoSitePlus
S250	O-Glycosylation		score1	GlyGen	30379171, 29351928
S250	Phosphorylation		score1	PhosphoSitePlus
K253	Ubiquitination		score1	PhosphoSitePlus
K257	Ubiquitination		score1	PhosphoSitePlus
K271	Ubiquitination		score1	PhosphoSitePlus
Y276	Phosphorylation		score1	PhosphoSitePlus
K277	Acetylation		score1	PhosphoSitePlus
K277	Ubiquitination		score1	PhosphoSitePlus
S285	Phosphorylation		score1	PhosphoSitePlus
R286	Methylation		score1	PhosphoSitePlus
S299	Phosphorylation		score1	PhosphoSitePlus
Y301	Phosphorylation		score1	PhosphoSitePlus
Y306	Phosphorylation		score1	PhosphoSitePlus
K308	Ubiquitination		score1	PhosphoSitePlus
T350	O-Glycosylation		score1	GlyGen	30379171, 29351928
K360	Ubiquitination		score1	PhosphoSitePlus
Y364	Phosphorylation		score1	PhosphoSitePlus
Y374	Phosphorylation		score1	PhosphoSitePlus
Y377	Phosphorylation		score1	PhosphoSitePlus
S378	Phosphorylation		score1	PhosphoSitePlus
K391	Ubiquitination		score1	PhosphoSitePlus
T394	Phosphorylation		score1	PhosphoSitePlus
S398	Phosphorylation		score1	PhosphoSitePlus
C453	S-Nitrosylation		score2	dbSNO	15684422, 22178444
K486	Ubiquitination		score1	PhosphoSitePlus
S496	Phosphorylation		score1	PhosphoSitePlus
Y509	Phosphorylation		score1	PhosphoSitePlus
K521	Ubiquitination		score1	PhosphoSitePlus
K522	Ubiquitination		score1	PhosphoSitePlus
S528	Phosphorylation		score1	PhosphoSitePlus
K530	Ubiquitination		score1	PhosphoSitePlus
S534	Phosphorylation		score1	PhosphoSitePlus
Y536	Phosphorylation	P06213 (INSR) , P12931 (SRC) , A0A173G4P4 (Abl fusion) , P00519 (ABL1) , P06239 (LCK) , P07948 (LYN)	score4	IntAct neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor	23938089, 18377662, 14699166, ...24405902, 8692915, 7512963, 28250424, 18083107, 32792945, 17575265, 14757045, 17675340, 33370418, 12468540, 8114715, 8696915
T540	Phosphorylation		score1	PhosphoSitePlus
Y541	Phosphorylation		score3	IntAct PhosphoSitePlus	8114715
K546	Ubiquitination		score1	PhosphoSitePlus
S553	Phosphorylation		score1	PhosphoSitePlus
T555	Phosphorylation		score1	PhosphoSitePlus
S556	Phosphorylation		score1	PhosphoSitePlus
S557	Phosphorylation		score1	PhosphoSitePlus
K560	Ubiquitination		score1	PhosphoSitePlus
Y564	Phosphorylation	A0A173G4P4 (Abl fusion) , P00519 (ABL1) , P07948 (LYN) , P06239 (LCK) , P12931 (SRC)	score4	IntAct neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor UniProt	10488096, 8696915, 14699166, ...8692915, 16649996, 28250424, 18083107, 32792945, 10574931, 14757045, 33370418, 25535246, 12468540, 8114715
K570	Ubiquitination		score1	PhosphoSitePlus
S582	Phosphorylation		score1	PhosphoSitePlus
S588	Phosphorylation		score1	PhosphoSitePlus
S591	Phosphorylation	P17252 (PRKCA) , P24941 (CDK2)	score4	neXtProt phospho.ELM PhosphoSitePlus RLIMS-P Signor	18377662, 24405902, 28619847, ...21262353, 20351292, 15269224, 23938089, 32792945, 17575265, 18617527, 24947019, 23720348

Search:

Site Select all By amino acid All Serine All Tyrosine By position Y61 Y64 Y536 Y541 S557 Y564 S591	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0 1 2	Source Select all HPRD	PMID
Y61	Phosphorylation		score0	HPRD	15592455
Y64	Phosphorylation		score0	HPRD	15592455
Y536	Phosphorylation	P06213 (INSR) , P00519 (ABL1) , P06239 (LCK)	score2	HPRD	7512963, 16497976
Y541	Phosphorylation		score0	HPRD	16497976
S557	Phosphorylation		score0	HPRD	20166139
Y564	Phosphorylation	P07948 (LYN) , P00519 (ABL1) , P06239 (LCK)	score2	HPRD	10574931, 8692915, 10488096, ...8114715, 12468540
S591	Phosphorylation	P17252 (PRKCA)	score1	HPRD	15269224

Search:

Site Select all By amino acid All Serine All Tyrosine By position Y63 Y66 Y538 Y543 S559 Y566	PTM Type Select all Phosphorylation	PTM Enzyme	Score Select all 0 1 2	Source Select all HPRD	PMID
Y63	Phosphorylation		score0	HPRD	15592455
Y66	Phosphorylation		score0	HPRD	15592455
Y538	Phosphorylation	P06239 (LCK) , P06213 (INSR)	score2	HPRD	8114715, 16497976
Y543	Phosphorylation		score0	HPRD	16497976
S559	Phosphorylation		score0	HPRD	20166139
Y566	Phosphorylation	P06239 (LCK)	score1	HPRD	8114715

Search:

Site Select all By amino acid All Serine All Tyrosine By position Y61 Y64 Y536 Y541 S563	PTM Type Select all Phosphorylation	Score Select all 0 1	Source Select all HPRD PhosphoSitePlus	PMID
Y61	Phosphorylation	score0	HPRD	15592455
Y64	Phosphorylation	score0	HPRD	15592455
Y536	Phosphorylation	score0	HPRD	18083107, 16497976
Y541	Phosphorylation	score0	HPRD	16497976
S563	Phosphorylation	score1	PhosphoSitePlus

PTM-dependent PPI

Search:

	PTM type Select all Phosphorylation	Substrate Select all P06239 (LCK)	Site Select all By amino acid All Serine By position S59	Interactant Select all P29350 (PTPN6)	Association type Select all inhibited_association	Source Select all eFIP	PMID
	Phosphorylation	P06239 (LCK)	S59	P29350 (PTPN6)	inhibited_association	eFIP	29187853

PTM sites affected in variants

Search:

Site Select all By amino acid All Serine All Threonine All Tyrosine By position S10 S26 Y98 S151 K155 Y176 T188 K195 Y208 K253 R286 T350 S378 C453 S496 S528 S553 S556 K560 S591	Variant Select all * C98 F378 F453 F591 G151 I350 L286 L528 L556 M188 M195 M253 N10 N151 N155 N176 N26 P528 P553 R253 R26 T26	Source Select all Biomuta	Disease [Sample source] Select all DOID:10283 / prostate cancer [ cosmic ] DOID:11054 / urinary bladder cancer [ cosmic ] DOID:1324 / lung cancer [ cosmic ] DOID:1793 / pancreatic cancer [ icgc ] DOID:2394 / ovarian cancer [ cosmic, icgc ] DOID:2531 / hematologic cancer [ cosmic ] DOID:263 / kidney cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic ] DOID:3571 / liver cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ cosmic, icgc ] DOID:363 / uterine cancer [ icgc ] DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ] DOID:4159 / skin cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic ] DOID:8618 / oral cavity cancer [ cosmic ] DOID:9256 / colorectal cancer [ cosmic ] DOID:9256 / colorectal cancer [ icgc ] [ cosmic ]
S10	N10	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S26	N26	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S26	R26	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S26	T26	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
Y98	C98	Biomuta	DOID:1793 / pancreatic cancer [ icgc ]
S151	N151	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S151	G151	Biomuta	DOID:9256 / colorectal cancer [ icgc ]
K155	N155	Biomuta	DOID:4159 / skin cancer [ cosmic ]
Y176	N176	Biomuta	DOID:1324 / lung cancer [ cosmic ]
T188	M188	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
K195	M195	Biomuta	DOID:9256 / colorectal cancer [ cosmic ]
Y208	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
K253	M253	Biomuta	DOID:2394 / ovarian cancer [ cosmic, icgc ]
K253	R253	Biomuta	DOID:3571 / liver cancer [ cosmic, icgc ]
R286	*	Biomuta	DOID:10283 / prostate cancer [ cosmic ]
R286	L286	Biomuta	DOID:3571 / liver cancer [ cosmic ]
T350	I350	Biomuta	DOID:363 / uterine cancer [ icgc ] DOID:4159 / skin cancer [ cosmic ]
S378	F378	Biomuta	DOID:4159 / skin cancer [ cosmic ]
C453	F453	Biomuta	[ cosmic ]
S496	*	Biomuta	DOID:11054 / urinary bladder cancer [ cosmic ]
S528	P528	Biomuta	DOID:263 / kidney cancer [ cosmic ]
S528	L528	Biomuta	DOID:5041 / esophageal cancer [ cosmic ]
S553	P553	Biomuta	DOID:363 / uterine cancer [ cosmic, icgc ]
S556	L556	Biomuta	DOID:363 / uterine cancer [ icgc ]
K560	*	Biomuta	DOID:2531 / hematologic cancer [ cosmic ]
S591	F591	Biomuta	DOID:8618 / oral cavity cancer [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P29350 (PTPN6)

Protein Information

Interactive Sequence View

P29350 (PTPN6) as Substrate

PTM-dependent PPI

PTM sites affected in variants