Protein Information

Cytoscape View


UniProt AC / UniProt ID P29323 / EPHB2_HUMAN
Protein Name Ephrin type-B receptor 2 precursor
Gene Name Name: EPHB2
Synonyms:DRT,EPHT3,EPTH3,ERK,HEK5,TYRO5;
Organism Homo sapiens (Human)

PRO ID PR:P29323
DAG View
PRO Name ephrin type-B receptor 2 (human)
Definition An ephrin type-B receptor 2 that is encoded in the genome of human.
Short Label hEPHB2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P29323 (EPHB2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
S148 Phosphorylation PhosphoSitePlus
N265 N-Glycosylation GlyGen 23090970, 24190977
T276 Phosphorylation PhosphoSitePlus
Y481 Phosphorylation PhosphoSitePlus   RLIMS-P 28719605
N482 N-Glycosylation GlyGen 23090970, 24190977
Y504 Phosphorylation PhosphoSitePlus   RLIMS-P 28719605, 31996679
Y524 Phosphorylation PhosphoSitePlus
S575 Phosphorylation PhosphoSitePlus
Y577 Phosphorylation PhosphoSitePlus
T578 Phosphorylation PhosphoSitePlus
K580 Ubiquitination PhosphoSitePlus
Y584 Phosphorylation PhosphoSitePlus
T585 Phosphorylation PhosphoSitePlus
S586 Phosphorylation PhosphoSitePlus
T590 Phosphorylation PhosphoSitePlus
Y596 Phosphorylation neXtProt   PRO   PhosphoSitePlus 11572780, 19661068
Y596 Phosphorylation P29323 (EPHB2) neXtProt 11572780, 19661068
T601 Phosphorylation PhosphoSitePlus
Y602 Phosphorylation neXtProt   PRO   PhosphoSitePlus 11572780, 19661068
Y602 Phosphorylation P29323 (EPHB2) neXtProt 11572780, 19661068
K645 Ubiquitination PhosphoSitePlus
Y742 Phosphorylation PhosphoSitePlus
S756 Phosphorylation PhosphoSitePlus
S763 Phosphorylation PhosphoSitePlus
S768 Phosphorylation PhosphoSitePlus
T775 Phosphorylation phospho.ELM   PhosphoSitePlus 17192257
S776 Phosphorylation PhosphoSitePlus
T779 Phosphorylation PhosphoSitePlus
Y780 Phosphorylation PhosphoSitePlus
T781 Phosphorylation PhosphoSitePlus
Y800 Phosphorylation PhosphoSitePlus
S898 Phosphorylation PhosphoSitePlus
Y912 Phosphorylation PhosphoSitePlus
T959 Phosphorylation PhosphoSitePlus
K1020 Acetylation PhosphoSitePlus
K1024 Acetylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y577 Phosphorylation HPRD 10572014
Y584 Phosphorylation HPRD 18691976, 10572014
Y596 Phosphorylation HPRD 17016520, 10572014, 9233798
Y602 Phosphorylation HPRD 17016520, 10572014, 9632142, ...9233798
Y602 Phosphorylation P29323 (EPHB2) HPRD 17016520, 10572014, 9632142, ...9233798
Y659 Phosphorylation HPRD 10572014
Y736 Phosphorylation HPRD 10572014
Y742 Phosphorylation HPRD 10572014
T775 Phosphorylation HPRD 18578522, 17192257
T775 Phosphorylation P29323 (EPHB2) HPRD 18578522, 17192257
S776 Phosphorylation HPRD 18691976, 18578522, 20058876, ...17192257
S776 Phosphorylation P29323 (EPHB2) HPRD 18691976, 18578522, 20058876, ...17192257
Y780 Phosphorylation HPRD 17016520, 18691976, 10572014
Y800 Phosphorylation HPRD 10572014
Y930 Phosphorylation HPRD 10572014, 8798570
S983 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
Y578 Phosphorylation HPRD 10572014
Y585 Phosphorylation HPRD 18691976, 10572014
Y597 Phosphorylation HPRD 17016520, 10572014, 9233798
Y603 Phosphorylation HPRD 17016520, 10572014, 9632142, ...9233798
Y603 Phosphorylation P29323 (EPHB2) HPRD 17016520, 10572014, 9632142, ...9233798
Y660 Phosphorylation HPRD 10572014
Y737 Phosphorylation HPRD 10572014
Y743 Phosphorylation HPRD 10572014
T776 Phosphorylation HPRD 18578522, 17192257
T776 Phosphorylation P29323 (EPHB2) HPRD 18578522, 17192257
S777 Phosphorylation HPRD 18691976, 18578522, 20058876, ...17192257
S777 Phosphorylation P29323 (EPHB2) HPRD 18691976, 18578522, 20058876, ...17192257
Y781 Phosphorylation HPRD 17016520, 18691976, 10572014
Y801 Phosphorylation HPRD 10572014
Y931 Phosphorylation HPRD 10572014


P29323 (EPHB2) as PTM Enzyme



Substrate Site Score Source PMID
O94989 (ARHGEF15) Y353 neXtProt   Signor 21029865
P10301 (RRAS) Y66 HPRD   phospho.ELM   PhosphoSitePlus   Signor 10570155
P29323 (EPHB2) Y596 neXtProt 11572780, 19661068
P29323-2 (EPHB2) Y602 HPRD   neXtProt 17016520, 10572014, 19661068, ...11572780, 9632142, 9233798
P29323-3 (EPHB2) Y603 HPRD 17016520, 10572014, 9632142, ...9233798
P29323-2 (EPHB2) T775 HPRD 18578522, 17192257
P29323-2 (EPHB2) S776 HPRD 18691976, 18578522, 20058876, ...17192257
P29323-3 (EPHB2) T776 HPRD 18578522, 17192257
P29323-3 (EPHB2) S777 HPRD 18691976, 18578522, 20058876, ...17192257
P52799 (EFNB2) Y304 phospho.ELM 15096211
Q13224 (GRIN2B) Y1474 neXtProt 19661068
Q92823 (NRCAM) Y1276 neXtProt   Signor 24023801


Proteoforms

PRO ID (Short Label) Sites PTM Enzyme Source PMID
PR:000047305 (hEPHB2/SigPep-/Phos:1) pY596,pY602 PRO


PTM-dependent PPI

PTM type Substrate Site Interactant Association type Source PMID
Phosphorylation P51812 (RPS6KA3) Y529 P29323 (EPHB2) unknown eFIP 19223461


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
N265 D265 Biomuta DOID:263 / kidney cancer [ cosmic ]
S575 L575 Biomuta DOID:5041 / esophageal cancer [ icgc ]
T578 M578 Biomuta DOID:10534 / stomach cancer [ cosmic ]
T585 I585 Biomuta DOID:1612 / breast cancer [ cosmic, icgc ]
Y602 F602 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
T775 A775 Biomuta DOID:363 / uterine cancer [ tcga ]