iPTMnet Report P29323 EPHB2

Protein Information

UniProt AC / UniProt ID	P29323 / EPHB2_HUMAN
Protein Name	Ephrin type-B receptor 2 precursor
Gene Name	Name: EPHB2 Synonyms:DRT,EPHT3,EPTH3,ERK,HEK5,TYRO5;
Organism	Homo sapiens (Human)

PRO ID	PR:P29323 DAG View
PRO Name	ephrin type-B receptor 2 (human)
Definition	An ephrin type-B receptor 2 that is encoded in the genome of human.
Short Label	hEPHB2
Category	organism-gene

Interactive Sequence View

	Select/align proteoforms across species

P29323 (EPHB2) as Substrate

Condensed View

Site	PTM Type	PTM Enzyme	Score	Source	PMID
S148	Phosphorylation		score1	PhosphoSitePlus
N265	N-Glycosylation		score1	GlyGen	23090970, 24190977
T276	Phosphorylation		score1	PhosphoSitePlus
Y481	Phosphorylation		score3	PhosphoSitePlus RLIMS-P	28719605
N482	N-Glycosylation		score1	GlyGen	23090970, 24190977
T494	O-Glycosylation		score1	GlyGen	30379171
Y504	Phosphorylation		score4	PhosphoSitePlus RLIMS-P	28719605, 31996679
Y524	Phosphorylation		score1	PhosphoSitePlus
S575	Phosphorylation		score1	PhosphoSitePlus
Y577	Phosphorylation		score1	PhosphoSitePlus
T578	Phosphorylation		score1	PhosphoSitePlus
K580	Ubiquitination		score1	PhosphoSitePlus
Y584	Phosphorylation		score1	PhosphoSitePlus
T585	Phosphorylation		score1	PhosphoSitePlus
S586	Phosphorylation		score1	PhosphoSitePlus
T590	Phosphorylation		score1	PhosphoSitePlus
Y596	Phosphorylation		score4	neXtProt PRO PhosphoSitePlus	11572780, 19661068
Y596	Phosphorylation	P29323 (EPHB2)	score3	neXtProt	11572780, 19661068
T601	Phosphorylation		score1	PhosphoSitePlus
Y602	Phosphorylation		score4	neXtProt PRO PhosphoSitePlus	11572780, 19661068
Y602	Phosphorylation	P29323 (EPHB2)	score3	neXtProt	11572780, 19661068
K645	Ubiquitination		score1	PhosphoSitePlus
Y742	Phosphorylation		score1	PhosphoSitePlus
S756	Phosphorylation		score1	PhosphoSitePlus
S763	Phosphorylation		score1	PhosphoSitePlus
S768	Phosphorylation		score1	PhosphoSitePlus
T775	Phosphorylation		score2	phospho.ELM PhosphoSitePlus	17192257
S776	Phosphorylation		score1	PhosphoSitePlus
T779	Phosphorylation		score1	PhosphoSitePlus
Y780	Phosphorylation		score1	PhosphoSitePlus
T781	Phosphorylation		score1	PhosphoSitePlus
K787	Ubiquitination		score1	PhosphoSitePlus
Y800	Phosphorylation		score1	PhosphoSitePlus
K891	Ubiquitination		score3	PhosphoSitePlus UniProt	33280498
S898	Phosphorylation		score1	PhosphoSitePlus
Y912	Phosphorylation		score1	PhosphoSitePlus
T959	Phosphorylation		score1	PhosphoSitePlus
S983	Phosphorylation		score1	UniProt	19369195
V984	Phosphorylation		score1	UniProt	19369195
K1020	Acetylation		score1	PhosphoSitePlus
K1024	Acetylation		score1	PhosphoSitePlus

Site	PTM Type	PTM Enzyme	Score	Source	PMID
Y577	Phosphorylation		score1	HPRD	10572014
Y584	Phosphorylation		score2	HPRD	18691976, 10572014
Y596	Phosphorylation		score2	HPRD	17016520, 10572014, 9233798
Y602	Phosphorylation		score2	HPRD	17016520, 10572014, 9632142, ...9233798
Y602	Phosphorylation	P29323 (EPHB2)	score2	HPRD	17016520, 10572014, 9632142, ...9233798
Y659	Phosphorylation		score1	HPRD	10572014
Y736	Phosphorylation		score1	HPRD	10572014
Y742	Phosphorylation		score1	HPRD	10572014
T775	Phosphorylation		score0	HPRD	18578522, 17192257
T775	Phosphorylation	P29323 (EPHB2)	score0	HPRD	18578522, 17192257
S776	Phosphorylation		score0	HPRD	18691976, 18578522, 20058876, ...17192257
S776	Phosphorylation	P29323 (EPHB2)	score0	HPRD	18691976, 18578522, 20058876, ...17192257
Y780	Phosphorylation		score2	HPRD	17016520, 18691976, 10572014
Y800	Phosphorylation		score1	HPRD	10572014
Y930	Phosphorylation		score2	HPRD	10572014, 8798570
S983	Phosphorylation		score1	PhosphoSitePlus

Site	PTM Type	PTM Enzyme	Score	Source	PMID
Y578	Phosphorylation		score1	HPRD	10572014
Y585	Phosphorylation		score2	HPRD	18691976, 10572014
Y597	Phosphorylation		score2	HPRD	17016520, 10572014, 9233798
Y603	Phosphorylation		score2	HPRD	17016520, 10572014, 9632142, ...9233798
Y603	Phosphorylation	P29323 (EPHB2)	score2	HPRD	17016520, 10572014, 9632142, ...9233798
Y660	Phosphorylation		score1	HPRD	10572014
Y737	Phosphorylation		score1	HPRD	10572014
Y743	Phosphorylation		score1	HPRD	10572014
T776	Phosphorylation		score0	HPRD	18578522, 17192257
T776	Phosphorylation	P29323 (EPHB2)	score0	HPRD	18578522, 17192257
S777	Phosphorylation		score0	HPRD	18691976, 18578522, 20058876, ...17192257
S777	Phosphorylation	P29323 (EPHB2)	score0	HPRD	18691976, 18578522, 20058876, ...17192257
Y781	Phosphorylation		score2	HPRD	17016520, 18691976, 10572014
Y801	Phosphorylation		score1	HPRD	10572014
Y931	Phosphorylation		score1	HPRD	10572014

P29323 (EPHB2) as PTM Enzyme

Protein as Phosphorylation Enzyme

Substrate	Site	Score	Source	PMID
O94989 (ARHGEF15)	Y353	score3	neXtProt Signor	21029865
P10301 (RRAS)	Y66	score3	HPRD phospho.ELM PhosphoSitePlus Signor	10570155
P29323 (EPHB2)	Y596	score3	neXtProt	11572780, 19661068
P29323 (EPHB2)	Y602	score4	HPRD neXtProt	17016520, 10572014, 19661068, ...11572780, 9632142, 9233798
P29323-3 (EPHB2)	Y603	score2	HPRD	17016520, 10572014, 9632142, ...9233798
P29323-2 (EPHB2)	T775	score0	HPRD	18578522, 17192257
P29323-2 (EPHB2)	S776	score0	HPRD	18691976, 18578522, 20058876, ...17192257
P29323-3 (EPHB2)	T776	score0	HPRD	18578522, 17192257
P29323-3 (EPHB2)	S777	score0	HPRD	18691976, 18578522, 20058876, ...17192257
P52799 (EFNB2)	Y304	score2	phospho.ELM	15096211
Q13224 (GRIN2B)	Y1474	score2	neXtProt	19661068
Q92823 (NRCAM)	Y1276	score3	neXtProt Signor	24023801

Proteoforms

	PRO ID (Short Label)	Sites	PTM Enzyme	Source	PMID
	PR:000047305 (hEPHB2/SigPep-/Phos:1)	pY596,pY602		PRO

PTM-dependent PPI

	PTM type	Substrate	Site	Interactant	Association type	Source	PMID
	Phosphorylation	P51812 (RPS6KA3)	Y529	P29323 (EPHB2)	unknown	eFIP	19223461

PTM sites affected in variants

Site	Variant	Source	Disease [Sample source]
N265	D265	Biomuta	DOID:263 / kidney cancer [ cosmic ]
S575	*	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S575	L575	Biomuta	DOID:9256 / colorectal cancer [ cosmic ] DOID:5041 / esophageal cancer [ cosmic, icgc ]
T578	M578	Biomuta	DOID:10534 / stomach cancer [ cosmic ]
T585	I585	Biomuta	DOID:1612 / breast cancer [ cosmic, icgc ]
Y602	F602	Biomuta	DOID:3571 / liver cancer [ cosmic ]
Y603	F603	Biomuta	DOID:3571 / liver cancer [ cosmic ]
S763	L763	Biomuta	DOID:1324 / lung cancer [ cosmic ]
S768	L768	Biomuta	DOID:4159 / skin cancer [ cosmic ]
T775	A775	Biomuta	DOID:363 / uterine cancer [ icgc ]
T776	A776	Biomuta	DOID:363 / uterine cancer [ icgc ]
Y800	*	Biomuta	DOID:363 / uterine cancer [ icgc ] DOID:1725 / peritoneum cancer [ cosmic, cosmic ] DOID:3571 / liver cancer [ cosmic ]
Y801	*	Biomuta	DOID:1725 / peritoneum cancer [ cosmic ]
Y930	C930	Biomuta	DOID:3565 / meningioma [ cosmic ]
Y931	C931	Biomuta	DOID:3565 / meningioma [ cosmic ]

PTM Type		Select All, None
Acetylation	N-Glycosylation	O-Glycosylation
C-Glycosylation	S-Glycosylation	Methylation
Myristoylation	Phosphorylation	Sumoylation
Ubiquitination	S-Nitrosylation

Select organisms		Select All, None
Human	Mouse	Rat
Cow	Chicken	Zebrafish
Fruit fly	C. elegans	Baker's yeast
Fission yeast	A. thaliana	Maize
M. truncatula	Rice (japonica)	Rice (indica)

Or input other organisms

iPTMnet Report for P29323 (EPHB2)

Protein Information

Interactive Sequence View

P29323 (EPHB2) as Substrate

P29323 (EPHB2) as PTM Enzyme

Proteoforms

PTM-dependent PPI

PTM sites affected in variants