Protein Information

Cytoscape View


UniProt AC / UniProt ID P29144 / TPP2_HUMAN
Protein Name Tripeptidyl-peptidase 2
Gene Name Name: TPP2
Organism Homo sapiens (Human)

PRO ID PR:P29144
DAG View
PRO Name tripeptidyl-peptidase 2 (human)
Definition A tripeptidyl-peptidase 2 that is encoded in the genome of human.
Short Label hTPP2
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P29144 (TPP2) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K19 Ubiquitination PhosphoSitePlus
S25 Phosphorylation PhosphoSitePlus
K61 Ubiquitination PhosphoSitePlus
S93 Phosphorylation PhosphoSitePlus
K109 Ubiquitination PhosphoSitePlus
Y118 Phosphorylation PhosphoSitePlus
K136 Methylation PhosphoSitePlus
K136 Ubiquitination PhosphoSitePlus
K152 Ubiquitination PhosphoSitePlus
K168 Ubiquitination PhosphoSitePlus
K171 Ubiquitination PhosphoSitePlus
K186 Ubiquitination PhosphoSitePlus
K220 Ubiquitination PhosphoSitePlus
S221 Phosphorylation HPRD 20068231
Y227 Phosphorylation HPRD   PhosphoSitePlus 20068231
K321 Ubiquitination PhosphoSitePlus
K401 Ubiquitination PhosphoSitePlus
T442 Phosphorylation PhosphoSitePlus
K467 Methylation PhosphoSitePlus
T485 Phosphorylation HPRD   PhosphoSitePlus 20068231
Y610 Phosphorylation PhosphoSitePlus
S643 Phosphorylation PhosphoSitePlus
Y645 Phosphorylation PhosphoSitePlus
K655 Ubiquitination PhosphoSitePlus
K697 Ubiquitination PhosphoSitePlus
K708 Acetylation PhosphoSitePlus
K708 Ubiquitination PhosphoSitePlus
K715 Ubiquitination PhosphoSitePlus
K791 Ubiquitination PhosphoSitePlus
S801 Phosphorylation PhosphoSitePlus
S869 Phosphorylation PhosphoSitePlus
K883 Acetylation PhosphoSitePlus
K883 Ubiquitination PhosphoSitePlus
S898 Phosphorylation PhosphoSitePlus
K904 Ubiquitination PhosphoSitePlus
S911 Phosphorylation PhosphoSitePlus
S915 Phosphorylation PhosphoSitePlus   UniProt 24275569
K958 Ubiquitination PhosphoSitePlus
K1005 Ubiquitination PhosphoSitePlus
K1013 Ubiquitination PhosphoSitePlus
K1018 Ubiquitination PhosphoSitePlus
K1029 Ubiquitination PhosphoSitePlus
S1039 Phosphorylation PhosphoSitePlus
Y1042 Phosphorylation PhosphoSitePlus
K1046 Ubiquitination PhosphoSitePlus
Y1052 Phosphorylation PhosphoSitePlus
Y1056 Phosphorylation PhosphoSitePlus
K1127 Ubiquitination PhosphoSitePlus
K1180 Ubiquitination PhosphoSitePlus
T1183 Phosphorylation PhosphoSitePlus
Y1186 Phosphorylation PhosphoSitePlus
K1193 Ubiquitination PhosphoSitePlus
K1200 Ubiquitination PhosphoSitePlus
K1204 Acetylation PhosphoSitePlus
K1204 Ubiquitination PhosphoSitePlus
K1209 Ubiquitination PhosphoSitePlus
K1212 Ubiquitination PhosphoSitePlus
K1216 Ubiquitination PhosphoSitePlus


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
S25 Y25 Biomuta DOID:1793 / pancreatic cancer [ tcga ]
S93 L93 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K136 N136 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
S221 F221 Biomuta DOID:11054 / urinary bladder cancer [ cosmic, icgc, tcga ]
T442 M442 Biomuta DOID:1612 / breast cancer [ cosmic ] DOID:5041 / esophageal cancer [ icgc ]
T442 A442 Biomuta DOID:363 / uterine cancer [ cosmic, icgc, tcga ]
K958 E958 Biomuta DOID:3070 / malignant glioma [ tcga ]
K1013 R1013 Biomuta DOID:3963 / thyroid carcinoma [ cosmic, icgc ]
S1039 C1039 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
Y1056 F1056 Biomuta DOID:3571 / liver cancer [ icgc ] DOID:0070003 / blastoma [ cosmic ]
K1193 E1193 Biomuta DOID:363 / uterine cancer [ tcga ]
K1209 N1209 Biomuta DOID:10534 / stomach cancer [ cosmic, icgc, tcga ]