iPTMnet Report for P29122 (PCSK6)


Protein Information

Cytoscape View


UniProt AC / UniProt ID P29122 / PCSK6_HUMAN
Protein Name Proprotein convertase subtilisin/kexin type 6 precursor
Gene Name Name: PCSK6
Synonyms:PACE4;
Organism Homo sapiens (Human)

PRO ID PR:P29122
DAG View
PRO Name proprotein convertase subtilisin/kexin type 6 (human)
Definition A proprotein convertase subtilisin/kexin type 6 that is encoded in the genome of human.
Short Label hPCSK6
Category organism-gene

Interactive Sequence View

Select/align proteoforms across species


P29122 (PCSK6) as Substrate



Site PTM Type PTM Enzyme Score Source PMID
K136 Ubiquitination PhosphoSitePlus
K323 Ubiquitination PhosphoSitePlus
K331 Ubiquitination PhosphoSitePlus
K459 Ubiquitination PhosphoSitePlus
K464 Ubiquitination PhosphoSitePlus
Y637 Phosphorylation PhosphoSitePlus
T683 O-Glycosylation GlyGen 30459171
T755 Phosphorylation PhosphoSitePlus
S757 Phosphorylation PhosphoSitePlus
T815 Phosphorylation PhosphoSitePlus
S822 Phosphorylation PhosphoSitePlus
Site PTM Type PTM Enzyme Score Source PMID
T815 Phosphorylation HPRD 19415658
Site PTM Type PTM Enzyme Score Source PMID
T802 Phosphorylation HPRD 19415658


PTM sites affected in variants

Site Variant Source PMID Disease [Sample source]
K136 R136 Biomuta DOID:1324 / lung cancer [ cosmic ]
Y637 H637 Biomuta DOID:8618 / oral cavity cancer [ cosmic ]
S822 C822 Biomuta DOID:3571 / liver cancer [ cosmic ]
S822 N822 Biomuta DOID:4159 / skin cancer [ cosmic ]